... appropriate inhibitors to identify stage-specific events. We have adopted this approach to study a group of benzyl- O - N -acetyl- D -galactosamine analogues in human colorectal cancer cell lines. Exposure to O-glycan inhibitors resulted in the induction of apoptosis, a block in proliferation, accumulation...

... a library of O-glycosylation inhibitors based on benzyl- O - N -acetyl- D -galactosamine. These inhibitors were tested with an established series of human colorectal cancer cell lines, which model the adenoma-carcinoma sequence. Cancer cells were incubated with the inhibitors, and examined for cell growth...