... Th. Somogyi P. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations Science 2008 321 53 57 3 Möhler H. Okada T. Benzodiazepine receptor: demonstration in the central nervous system Science 1977 198 849 851 4 Möhler H...

... A receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology J. Neurochem. 1990 54 1802 1804 14 Brickley S.G. Revilla V. Cull-Candy S.G. Wisden W. Farrant M. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance...

.... Indeed, it made possible the discovery of a novel benzodiazepine site. We use here subunit concatenation to study δ-subunit-containing GABA A receptors. We provide evidence for the formation of different functional subunit arrangements in recombinant α 1 β 3 δ and α 6 β 3 δ receptors. As with all...

... are constructed as pentameric ion channels, with α and β subunits being the minimal requirement, and the incorporation of a γ subunit being necessary for benzodiazepine modulation and synaptic targeting. Insights have been provided by the discovery of several specific assembly signals within different GABA...

... of the modulatory site for benzodiazepines on the γ 2 subunit, Phe 77 , and the homologous residue in the β 2 subunit, Tyr 62 , are shown (numbering of the rat GABA A receptor). In general, if a subunit occurs twice in a pentameric receptor and the receptor is not symmetrical, the positions of these two subunits...

... that have unique regional distributions, but little is known about the role played by each subtype. The majority of the receptors contain a γ 2 subunit and are sensitive to modulation by BZs (benzodiazepines), but differ with regard to α and β subunits. Mutagenesis studies combined with molecular modelling...