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Keywords: benzodiazepine
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Articles
Biochem Soc Trans (2009) 37 (6): 1338–1342.
Published: 19 November 2009
.... Indeed, it made possible the discovery of a novel benzodiazepine site. We use here subunit concatenation to study δ-subunit-containing GABA A receptors. We provide evidence for the formation of different functional subunit arrangements in recombinant α 1 β 3 δ and α 6 β 3 δ receptors. As with all...
Articles
Biochem Soc Trans (2009) 37 (6): 1328–1333.
Published: 19 November 2009
... in the treatment of CNS diseases, ranging from anxiety disorders, insomnias and memory dysfunctions to cognitive deficits and pain, based on the modulation of inhibitory control. anxiety benzodiazepine cognition γ-aminobutyric acid type A receptor (GABA A receptor) pain schizophrenia The term...
Articles
Biochem Soc Trans (2009) 37 (6): 1334–1337.
Published: 19 November 2009
... correspondence should be addressed (email beverley.orser@utoronto.ca ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 benzodiazepine brain conductance γ-aminobutyric acid subtype A receptor (GABA A R) hippocampal pyramidal neuron long-term potentiation (LTP...
Articles
Biochem Soc Trans (2006) 34 (5): 863–867.
Published: 25 October 2006
... are constructed as pentameric ion channels, with α and β subunits being the minimal requirement, and the incorporation of a γ subunit being necessary for benzodiazepine modulation and synaptic targeting. Insights have been provided by the discovery of several specific assembly signals within different GABA...
Articles
Biochem Soc Trans (2006) 34 (5): 868–871.
Published: 25 October 2006
... GABA A GABA type A 1 To whom correspondence should be addressed (email erwin.sigel@mci.unibe.ch ). 16 6 2006 © 2006 The Biochemical Society 2006 benzodiazepine concatenated subunit γ-aminobutyric acid (GABA) γ-aminobutyric acid type A receptor (GABA A receptor...
Articles
Biochem Soc Trans (2004) 32 (3): 553–556.
Published: 01 June 2004
... that have unique regional distributions, but little is known about the role played by each subtype. The majority of the receptors contain a γ 2 subunit and are sensitive to modulation by BZs (benzodiazepines), but differ with regard to α and β subunits. Mutagenesis studies combined with molecular modelling...