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Keywords: benzodiazepine
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Biochem Soc Trans (2009) 37 (6): 1328–1333.
Published: 19 November 2009
... recognized. The clinical proof-of-concept of a subtype-specific pharmacology is most advanced for the alleviation of cognitive dysfunctions in schizophrenia, based on the treatment of patients with an α 2 /α 3 -GABA A receptor ligand. anxiety benzodiazepine cognition γ-aminobutyric acid type...
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Biochem Soc Trans (2009) 37 (6): 1334–1337.
Published: 19 November 2009
... ]. Inverse agonists with selective binding or preferred efficacy for α 5 -GABA A Rs inhibit receptor activity allosterically via the benzodiazepine-binding site. The α 5 -GABA A R-function inverse agonist α 5 IA improves water maze learning and synaptic plasticity [ 41 ]. In vivo , this drug has no apparent...
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Biochem Soc Trans (2006) 34 (5): 863–867.
Published: 25 October 2006
... are constructed as pentameric ion channels, with α and β subunits being the minimal requirement, and the incorporation of a γ subunit being necessary for benzodiazepine modulation and synaptic targeting. Insights have been provided by the discovery of several specific assembly signals within different GABA...
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Biochem Soc Trans (2006) 34 (5): 868–871.
Published: 25 October 2006
... benzodiazepine concatenated subunit γ-aminobutyric acid (GABA) γ-aminobutyric acid type A receptor (GABA A receptor) subunit positioning subunit specificity During the last few years, subunit concatenation has been applied to members of the pentameric ligand-gated ion channel family. Covalently...
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Biochem Soc Trans (2004) 32 (3): 553–556.
Published: 01 June 2004
... that have unique regional distributions, but little is known about the role played by each subtype. The majority of the receptors contain a γ 2 subunit and are sensitive to modulation by BZs (benzodiazepines), but differ with regard to α and β subunits. Mutagenesis studies combined with molecular modelling...