... of how UV-DDB may be the first responder to alter the structure of damage containing-nucleosomes to allow access by base excision repair (BER) enzymes. Correspondence: Bennett Van Houten ( vanhoutenb@upmc.edu ) 8 8 2022 4 10 2022 10 10 2022 © 2022 The Author(s) 2022...

... on Oxidative DNA Damage has concluded that the true levels of the most widely studied lesion, 8-oxodG (8-oxo-7,8-dihydro-2′-deoxyguanosine), in cellular DNA is between 0.5 and 5 lesions per 10 6 dG bases. Base excision repair of oxidative damage to DNA can be assessed by nicking assays based...

...J.L. Parsons; G.L. Dianov BER (base excision repair) is a major pathway for the removal of simple lesions in DNA including base damage and base loss (abasic site). We have developed an assay, using formaldehyde cross-linking during repair in human cell extracts, to observe BER proteins involved...

... Stress Responses and Cancer meeting of the Biochemical SocietyIrish Area Section Meeting held at National University of Ireland, Galway, 4–5 July 2002 10 October 2002 Copyright 2003 Biochemical Society 2003 aprataxin base excision repair poly(ADP-ribose) polymerase-1...