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Keywords: autophagy
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Articles
Biochem Soc Trans (2022) 50 (1): 621–632.
Published: 28 February 2022
... and represent key events in the development and progression of the pathology. The present minireview covers recent articles (2018–2021) investigating the role of LRRK2 and LRRK2 mutants in the regulation of synaptic activity and autophagy-lysosomal pathway. These articles confirm a perturbation of synaptic...
Articles
Biochem Soc Trans (2022) 50 (1): 47–54.
Published: 15 February 2022
...Shuhei Nakamura; Shiori Akayama; Tamotsu Yoshimori Autophagy is an evolutionally conserved cytoplasmic degradation pathway in which the double membrane structure, autophagosome sequesters cytoplasmic material and delivers them to lysosomes for degradation. Many autophagy related (ATG) proteins...
Articles
Biochem Soc Trans (2022) 50 (1): 55–69.
Published: 25 January 2022
...Yan Hu; Fulvio Reggiori Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders...
Articles
Biochem Soc Trans (2021) 49 (5): 2199–2210.
Published: 19 October 2021
...Nicholas T. Ktistakis The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed...
Articles
Biochem Soc Trans (2021) 49 (2): 551–562.
Published: 26 March 2021
... in this disease. In recent years, defective mitochondrial elimination through autophagy, termed mitophagy, has emerged as a potential contributing factor to disease pathology. PINK1 and Parkin, two proteins mutated in familial PD, were found to eliminate mitochondria under distinct mitochondrial depolarisation...
Articles
Biochem Soc Trans (2020) 48 (5): 2003–2014.
Published: 08 September 2020
...Jahangir Md. Alam; Nobuo N. Noda Autophagy is a lysosomal degradation system that involves de novo autophagosome formation. A lot of factors are involved in autophagosome formation, including dozens of Atg proteins that form supramolecular complexes, membrane structures including vesicles...
Articles
Biochem Soc Trans (2020) 48 (4): 1599–1607.
Published: 14 July 2020
...Syn Kok Yeo; Chenran Wang; Jun-Lin Guan FIP200 (RB1CC1) is a critical regulator of canonical macroautophagy and has also emerged as a crucial regulator of selective autophagy as well as inflammatory processes. The illumination of FIP200's role in autophagy at the molecular level has been...
Articles
Biochem Soc Trans (2019) 47 (4): 1173–1185.
Published: 05 August 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 autophagy lysosomes membrane contact sites nutrient signaling phosphosinositides Lysosomes have long been regarded solely as a degradative compartment in eukaryotic cells. However, in recent years...
Articles
Biochem Soc Trans (2018) 46 (4): 877–889.
Published: 19 July 2018
... and/or triggering of NPC quality control mechanisms can lead to herniations in budding yeast, which are remarkably similar to those observed in human disease models of early-onset dystonia. By also examining the provenance of nuclear envelope herniations associated with emerging nuclear autophagy and nuclear egress...
Articles
Biochem Soc Trans (2018) 46 (1): 97–110.
Published: 05 January 2018
...Kevin C. Yang; Paalini Sathiyaseelan; Cally Ho; Sharon M. Gorski Autophagy is an evolutionarily conserved lysosome-mediated degradation and recycling process, which functions in cellular homeostasis and stress adaptation. The process is highly dynamic and involves autophagosome synthesis, cargo...
Articles
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy endoplasmic reticulum trafficking The discovery of the omegasome was a major breakthrough in autophagy research with respect...
Articles
Biochem Soc Trans (2017) 45 (1): 155–162.
Published: 15 February 2017
..., therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all...
Articles
Biochem Soc Trans (2016) 44 (6): 1603–1610.
Published: 02 December 2016
..., and several recent studies have suggested that the Rab family of small GTPases might be important in controlling the recruitment of LRRK2 to specific cellular compartments. Once localized to membranes, LRRK2 then influences downstream events, evidenced by changes in the autophagy–lysosome pathway. Here, I...
Articles
Biochem Soc Trans (2016) 44 (2): 431–440.
Published: 11 April 2016
... homoeostasis imbalance, the dynamics of peroxisomes have been widely examined. The increasing volume of reports demonstrating significant involvement of the autophagy machinery in peroxisome removal leads us to summarize current knowledge of peroxisome degradation in mammalian cells. In this review we present...
Articles
Biochem Soc Trans (2016) 44 (2): 541–545.
Published: 11 April 2016
... on evolutionarily conserved pathways. * To whom correspondence should be addressed (email ahagai@agri.huji.ac.il ). 25 1 2016 © 2016 Authors; published by Portland Press Limited 2016 autophagy degradation mitochondria stress response Mitochondria perform a variety of essential...
Articles
Biochem Soc Trans (2015) 43 (5): 1122–1126.
Published: 09 October 2015
...-tumoural action THC binding to cannabinoid receptors triggers an ER stress-related pathway that leads to the up-regulation of TRIB3, the subsequent inhibition of the AKT/mTORC1 axis and the stimulation of autophagy-mediated cancer cell death (see text for details). We also found that this cascade...
Articles
Biochem Soc Trans (2015) 43 (4): 543–552.
Published: 03 August 2015
... autophagy. This review focuses on the current understanding of this pathway and focuses on the interplay with reactive oxygen species (ROS) and the voltage-dependent anion channel (VDAC), to which TSPO binds, in the regulation of cell mitophagy and hence homoeostasis of the mitochondrial network as a whole...
Articles
Biochem Soc Trans (2015) 43 (3): 476–481.
Published: 01 June 2015
... junctions (GJ). Cardiomyocytes are the major cell population in the heart, and as cells with low mitotic activity, are highly dependent upon mechanisms of protein degradation. In the heart, both the ubiquitin-proteasome system (UPS) and autophagy participate in the fine-tune regulation of cardiac...
Articles
Biochem Soc Trans (2015) 43 (3): 471–475.
Published: 01 June 2015
... and consequently causes the stabilization of the protein at the PM [ 36 ]. autophagy connexin 43 endocytosis gap junction ubiquitin Similar to many other biological processes, protein ubiquitination is a reversible modification, catalysed by deubiquitinating enzymes (DUBs). These enzymes cleave...
Articles
Biochem Soc Trans (2015) 43 (3): 390–395.
Published: 01 June 2015
... indicate that pathogenic LRRK2 alters a variety of intracellular vesicular trafficking steps including endocytosis, autophagy, retromer-mediated trafficking from late endosomes to the trans -Golgi complex, lysosome size/positioning and Golgi integrity [ 12 , 15 – 20 ] ( Figure 2 ). Thus, LRRK2 may...
Articles
Biochem Soc Trans (2015) 43 (2): 229–234.
Published: 07 April 2015
... survival, differentiation and now autophagy. Herein, we describe how myristoylation may play a role in autophagy with an emphasis on PTMyr. 1 To whom correspondence should be addressed (email dalem@cmmt.ubc.ca ). 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society...
Articles
Biochem Soc Trans (2014) 42 (5): 1414–1417.
Published: 18 September 2014
...Simon G. Pfisterer; Daniela Bakula; Alice Cezanne; Horst Robenek; Tassula Proikas-Cezanne Macroautophagy (autophagy hereafter) is an evolutionarily highly conserved catabolic process activated by eukaryotes in order to counteract cellular starvation. Autophagy leads to bulk degradation...
Articles
Biochem Soc Trans (2014) 42 (5): 1389–1395.
Published: 18 September 2014
... gaps in our knowledge that need additional work. autophagy mammalian (or mechanistic) target of rapamycin complex 1 (mTORC1) phosphatidylinositol 3-phosphate (PI3P) phosphoinositide Unc-51-like kinase (ULK) complex vacuolar protein sorting 34 (VPS34) complex I Autophagy is conserved...
Articles
Biochem Soc Trans (2014) 42 (5): 1327–1334.
Published: 18 September 2014
...Michael I. Wilson; Hannah C. Dooley; Sharon A. Tooze The double-membraned autophagosome organelle is an integral part of autophagy, a process that recycles cellular components by non-selectively engulfing and delivering them to lysosomes where they are digested. Release of metabolites from...
Includes: Supplementary data
Articles
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
...Xiaoting Wu; Hyeran Won; David C. Rubinsztein Autophagy is a highly conserved cytoplasmic degradation pathway that has an impact on many physiological and disease states, including immunity, tumorigenesis and neurodegeneration. Recent studies suggest that autophagy may also have important functions...
Articles
Biochem Soc Trans (2013) 41 (6): 1503–1508.
Published: 20 November 2013
... (α-synuclein) multiplication and idiopathic PD. In some cases, isogenic control lines have been created to minimize inherent variability between lines from different individuals. Disruptions in autophagy, mitochondrial function and dopamine biology at the synapse have been described. Future...
Articles
Biochem Soc Trans (2013) 41 (6): 1598–1604.
Published: 20 November 2013
.... When we compared the potential mutSOD1 toxicity in motoneuron (NSC34) and muscle (C2C12) cells, we found that muscle ALS models possess much higher chymotryptic proteasome activity and autophagy power than motoneuron ALS models. As a result, mutSOD1 molecular behaviour was found to be very different...
Articles
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
... and that their failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as ‘saviour’ and ‘victim’ in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic...
Articles
Biochem Soc Trans (2013) 41 (5): 1103–1130.
Published: 23 September 2013
...Sovan Sarkar Autophagy is an intracellular degradation pathway essential for cellular and energy homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles, as well as recycling of cytosolic components during starvation to compensate for nutrient deprivation...
Articles
Biochem Soc Trans (2013) 41 (4): 962–967.
Published: 18 July 2013
...Daniela Bakula; Zsuzsanna Takacs; Tassula Proikas-Cezanne Autophagy is a catabolic pathway in which the cell sequesters cytoplasmic material, including long-lived proteins, lipids and organelles, in specialized double-membrane vesicles, called autophagosomes. Subsequently, autophagosomes...
Articles
Biochem Soc Trans (2013) 41 (4): 939–943.
Published: 18 July 2013
... of the cell and appropriately dictates whether the cell will actively favour energy- and amino-acid-consuming anabolic processes such as cellular growth, or energy- and amino-acid-generating catabolic processes such as autophagy. The present review discusses important feedback mechanisms between these three...
Articles
Biochem Soc Trans (2012) 40 (6): 1368–1372.
Published: 21 November 2012
..., suggesting that increased activation of Rab7 causes the disease [ 18 , 19 ]. These data indicate that a target therapy for CMT2B could be based on lowering Rab7 activity. Autophagy is involved in a wide range of physiological and pathological processes, as responses to nutrient deprivation...
Articles
Biochem Soc Trans (2012) 40 (5): 1070–1073.
Published: 19 September 2012
... acute effects in a very reductionist system, one benefit is that it is relatively easy to assay large numbers of variants in a rapid manner. autophagy cell death inclusion body leucine-rich repeat kinase 2 (LRRK2) neurite Parkinson's disease The identification of dominant mutations...
Articles
Biochem Soc Trans (2012) 40 (5): 1129–1133.
Published: 19 September 2012
... of autophagy regulation. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles. In the present paper, we discuss the role of LRRK2 in autophagy, and the importance of this relationship in the development of nigral degeneration in PD...
Articles
Biochem Soc Trans (2012) 40 (5): 1052–1057.
Published: 19 September 2012
...@weizmann.ac.il ). 19 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy autophosphorylation DAPK (death-associated protein kinase) leucine-rich repeat kinase 2 (LRRK2) The ROCO proteins are defined by predicted sequence similarity within two...
Articles
Biochem Soc Trans (2012) 40 (5): 1147–1151.
Published: 19 September 2012
... LRRK2 and autophagy. Implications of this set of data for our understanding of LRRK2′s role in physiology and disease are discussed in the present paper. 1 email c.manzoni@ucl.ac.uk LRRK2: Function and Dysfunction: A Biochemical Society Focused Meeting held at Royal Holloway...
Articles
Biochem Soc Trans (2012) 40 (5): 1080–1085.
Published: 19 September 2012
... correspondence should be addressed (email javier.alegre@dpag.ox.ac.uk ). 25 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy cytoskeleton dopamine leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease tau Mutations in the LRRK2 (leucine-rich...
Articles
Biochem Soc Trans (2012) 40 (5): 1042–1046.
Published: 19 September 2012
... as well as impaired dopamine D 2 receptor-mediated functions. Whereas LRRK2 −/− brains are normal, LRRK2 −/− kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy–lysosomal pathway, and increases in apoptotic cell...
Articles
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... for treatment of various tauopathies. In the present paper, we summarize data regarding characterization of MSUT2 (mammalian suppressor of tau pathology 2), a protein identified in a C. elegans tauopathy model and subsequently shown to modify tau toxicity in mammalian cell culture via the effects on autophagy...
Articles
Biochem Soc Trans (2012) 40 (4): 644–652.
Published: 20 July 2012
... on the UPS (ubiquitin–proteasome system) and the ALS (autophagy–lysosome system). In the present paper, we focus on the regulation of the degradation of tau by the UPS and ALS and its relation to tau aggregation. We anticipate that stimulation of these two protein-degradation systems might be a potential...
Articles
Biochem Soc Trans (2012) 40 (1): 37–43.
Published: 19 January 2012
...Nicholas T. Ktistakis; Maria Manifava; Priya Schoenfelder; Sergio Rotondo The simple phosphoinositide PtdIns3 P has been shown to control cell growth downstream of amino acid signalling and autophagy downstream of amino acid withdrawal. These opposing effects depend in part on the existence...
Articles
Biochem Soc Trans (2011) 39 (5): 1466–1470.
Published: 21 September 2011
...Belém Sampaio-Marques; Carolina Felgueiras; Alexandra Silva; Fernando Rodrigues; Paula Ludovico Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy...
Articles
Biochem Soc Trans (2011) 39 (5): 1514–1519.
Published: 21 September 2011
...Matthias Müller; Andreas S. Reichert Autophagy is a fundamental cellular process promoting survival under various environmental stress conditions. Selective types of autophagy have gained much interest recently as they are involved in specific quality control mechanisms removing, for example...
Articles
Biochem Soc Trans (2011) 39 (4): 1067–1072.
Published: 20 July 2011
... 2011 Biochemical Society 2011 autophagy Crohn's disease dysbiosis microbiota ulcerative colitis UC (ulcerative colitis) and Crohn's disease are the two predominant phenotypes of IBD (inflammatory bowel disease). Crohn's disease can cause transmural inflammation, affect any part...
Articles
Biochem Soc Trans (2011) 39 (2): 460–465.
Published: 22 March 2011
... with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
... correspondence should be addressed (email psaftig@biochem.uni-kiel.de ). 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy cholesterol homoeostasis lysosome lysosome membrane protein phagocytosis trafficking The lysosomal membrane, a 7–10-nm...
Articles
Biochem Soc Trans (2010) 38 (6): 1436–1441.
Published: 24 November 2010
... be addressed (email steve.walkley@einstein.yu.edu ). 26 4 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy axonal spheroid axoplasmic transport lysosomal disease Niemann–Pick type C disease Purkinje cell Lysosomes in Health and Disease...
Articles
Biochem Soc Trans (2010) 38 (6): 1442–1447.
Published: 24 November 2010
.... 1 To whom correspondence should be addressed (email jmheard@pasteur.fr ). 26 4 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy Golgi matrix protein 130 (GM130) lysosomal storage disease (LSD) lysosome-associated membrane protein (LAMP...
Articles
Biochem Soc Trans (2010) 38 (1): 144–149.
Published: 19 January 2010
.... In addition to the ubiquitin–proteasome system, the aggresome–autophagy pathway has emerged as another crucial cellular defence system against toxic build-up of misfolded proteins. In contrast with basal autophagy that mediates non-selective, bulk clearance of misfolded proteins along with normal cellular...
Articles
Biochem Soc Trans (2009) 37 (1): 208–212.
Published: 20 January 2009
... in the endocytic pathway [ 22 ], autophagy [ 23 , 24 ], viral budding [ 25 ] and cytokinesis [ 26 , 27 ]. The role of CHMP2B in the endosome–lysosome and autophagy pathways, and their relevance to neurodegeneration are discussed further below. In the endocytic pathway, proteins from the cell membrane...