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Articles

The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism

Qiang Zhang, Bin Tian

Biochem Soc Trans (2023) BST20221128.

DOI: https://doi.org/10.1042/BST20221128

Published: 12 May 2023

... of a cell changes in cell proliferation, differentiation, and stress conditions. Here, we review the emerging theme of regulation of 3′UTR isoforms in cell metabolic reprogramming, focusing on cell growth and autophagy responses through the mTOR pathway. We discuss regulatory events that converge...

View article titled, The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism

Articles

The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease

Sharon Tran, Juliani Juliani, W. Douglas Fairlie, Erinna F. Lee

Biochem Soc Trans (2023) 51 (2): 811–826.

DOI: https://doi.org/10.1042/BST20221300

Published: 13 April 2023

...Sharon Tran; Juliani Juliani; W. Douglas Fairlie; Erinna F. Lee Landmark genome-wide association studies (GWAS) identified that mutations in autophagy genes correlated with inflammatory bowel disease (IBD), a heterogenous disease characterised by prolonged inflammation of the gastrointestinal tract...

View article titled, The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease

Articles

The functional importance of VCP to maintaining cellular protein homeostasis

Brittany A. Ahlstedt, Rakesh Ganji, Malavika Raman

Biochem Soc Trans (2022) 50 (5): 1457–1469.

DOI: https://doi.org/10.1042/BST20220648

Published: 05 October 2022

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy neurodegeneration organelles protein quality control ubiquitin Valosin-containing protein (VCP, also p97, or Cdc48p in yeast...

View article titled, The functional importance of VCP to maintaining cellular protein homeostasis

Articles

The role of autophagy-lysosomal pathway in motor neuron diseases

Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Angelo Poletti

Biochem Soc Trans (2022) 50 (5): 1489–1503.

DOI: https://doi.org/10.1042/BST20220778

Published: 16 September 2022

.... This pathomechanism may be directly related to mutations in genes encoding proteins involved in the protein quality control system, particularly the autophagy-lysosomal pathway (ALP). Alternatively, proteostasis alteration can be caused by aberrant proteins that tend to misfold and to aggregate, two related processes...

View article titled, The role of autophagy-lysosomal pathway in motor neuron diseases

Articles

Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway

Federica Albanese, Chiara Domenicale, Mattia Volta, Michele Morari

Biochem Soc Trans (2022) 50 (1): 621–632.

DOI: https://doi.org/10.1042/BST20211288

Published: 28 February 2022

... and represent key events in the development and progression of the pathology. The present minireview covers recent articles (2018–2021) investigating the role of LRRK2 and LRRK2 mutants in the regulation of synaptic activity and autophagy-lysosomal pathway. These articles confirm a perturbation of synaptic...

View article titled, Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway

Articles

Non-canonical roles of ATG8 for TFEB activation

In Collection

Cell death and survival

Shuhei Nakamura, Shiori Akayama, Tamotsu Yoshimori

Biochem Soc Trans (2022) 50 (1): 47–54.

DOI: https://doi.org/10.1042/BST20210813

Published: 15 February 2022

...Shuhei Nakamura; Shiori Akayama; Tamotsu Yoshimori Autophagy is an evolutionally conserved cytoplasmic degradation pathway in which the double membrane structure, autophagosome sequesters cytoplasmic material and delivers them to lysosomes for degradation. Many autophagy related (ATG) proteins...

View article titled, Non-canonical roles of ATG8 for TFEB activation

Articles

Molecular regulation of autophagosome formation

In Collection

Cell death and survival

Yan Hu, Fulvio Reggiori

Biochem Soc Trans (2022) 50 (1): 55–69.

DOI: https://doi.org/10.1042/BST20210819

Published: 25 January 2022

...Yan Hu; Fulvio Reggiori Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders...

View article titled, Molecular regulation of autophagosome formation

Articles

The dynamics of mitochondrial autophagy at the initiation stage

Nicholas T. Ktistakis

Biochem Soc Trans (2021) 49 (5): 2199–2210.

DOI: https://doi.org/10.1042/BST20210272

Published: 19 October 2021

...Nicholas T. Ktistakis The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed...

View article titled, The dynamics of mitochondrial autophagy at the initiation stage

Articles

Parkinson's disease and mitophagy: an emerging role for LRRK2

Francois Singh, Ian G. Ganley

Biochem Soc Trans (2021) 49 (2): 551–562.

DOI: https://doi.org/10.1042/BST20190236

Published: 26 March 2021

... in this disease. In recent years, defective mitochondrial elimination through autophagy, termed mitophagy, has emerged as a potential contributing factor to disease pathology. PINK1 and Parkin, two proteins mutated in familial PD, were found to eliminate mitochondria under distinct mitochondrial depolarisation...

View article titled, Parkinson's disease and mitophagy: an emerging role for LRRK2

Articles

In vitro reconstitution of autophagic processes

Jahangir Md. Alam, Nobuo N. Noda

Biochem Soc Trans (2020) 48 (5): 2003–2014.

DOI: https://doi.org/10.1042/BST20200130

Published: 08 September 2020

...Jahangir Md. Alam; Nobuo N. Noda Autophagy is a lysosomal degradation system that involves de novo autophagosome formation. A lot of factors are involved in autophagosome formation, including dozens of Atg proteins that form supramolecular complexes, membrane structures including vesicles...

View article titled, In vitro reconstitution of autophagic processes

Articles

Role of FIP200 in inflammatory processes beyond its canonical autophagy function

Syn Kok Yeo, Chenran Wang, Jun-Lin Guan

Biochem Soc Trans (2020) 48 (4): 1599–1607.

DOI: https://doi.org/10.1042/BST20191156

Published: 14 July 2020

...Syn Kok Yeo; Chenran Wang; Jun-Lin Guan FIP200 (RB1CC1) is a critical regulator of canonical macroautophagy and has also emerged as a crucial regulator of selective autophagy as well as inflammatory processes. The illumination of FIP200's role in autophagy at the molecular level has been...

View article titled, Role of FIP200 in inflammatory processes beyond its canonical autophagy function

Articles

Phosphoinositides in the control of lysosome function and homeostasis

Michael Ebner, Philipp Alexander Koch, Volker Haucke

Biochem Soc Trans (2019) 47 (4): 1173–1185.

DOI: https://doi.org/10.1042/BST20190158

Published: 05 August 2019

... (PHOSPHATASE) Lysosome–autophagosome fusion Joubert Syndrome, MORM syndrome PI(4)P PI4KIIα (KINASE) ALR, Lysosome and LRO biogenesis, Lysosome–autophagosome fusion Hermanski–Pudlak Syndrome, Gaucher's disease PI4KIIIβ (KINASE) Lysosome Biogenesis OCRL (PHOSPHATASE) Autophagy Lowe Syndrome...

View article titled, Phosphoinositides in the control of lysosome function and homeostasis

Articles

Fantastic nuclear envelope herniations and where to find them

David J. Thaller, C. Patrick Lusk

Biochem Soc Trans (2018) 46 (4): 877–889.

DOI: https://doi.org/10.1042/BST20170442

Published: 19 July 2018

... and/or triggering of NPC quality control mechanisms can lead to herniations in budding yeast, which are remarkably similar to those observed in human disease models of early-onset dystonia. By also examining the provenance of nuclear envelope herniations associated with emerging nuclear autophagy and nuclear egress...

View article titled, Fantastic nuclear envelope herniations and where to find them

Articles

Evolution of tools and methods for monitoring autophagic flux in mammalian cells

Kevin C. Yang, Paalini Sathiyaseelan, Cally Ho, Sharon M. Gorski

Biochem Soc Trans (2018) 46 (1): 97–110.

DOI: https://doi.org/10.1042/BST20170102

Published: 05 January 2018

...Kevin C. Yang; Paalini Sathiyaseelan; Cally Ho; Sharon M. Gorski Autophagy is an evolutionarily conserved lysosome-mediated degradation and recycling process, which functions in cellular homeostasis and stress adaptation. The process is highly dynamic and involves autophagosome synthesis, cargo...

View article titled, Evolution of tools and methods for monitoring autophagic flux in mammalian cells

Articles

Autophagy in the context of the cellular membrane-trafficking system: the enigma of Atg9 vesicles

Takeshi Noda

Biochem Soc Trans (2017) 45 (6): 1323–1331.

DOI: https://doi.org/10.1042/BST20170128

Published: 17 November 2017

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy endoplasmic reticulum trafficking Autophagy is an intracellular degradation process that contributes to cellular homeostasis. Because...

View article titled, Autophagy in the context of the cellular membrane-trafficking system: the enigma of Atg9 vesicles

Articles

The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Claudia Manzoni

Biochem Soc Trans (2017) 45 (1): 155–162.

DOI: https://doi.org/10.1042/BST20160265

Published: 15 February 2017

..., therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all...

View article titled, The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Articles

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease

Mark R. Cookson

Biochem Soc Trans (2016) 44 (6): 1603–1610.

DOI: https://doi.org/10.1042/BST20160228

Published: 02 December 2016

..., and several recent studies have suggested that the Rab family of small GTPases might be important in controlling the recruitment of LRRK2 to specific cellular compartments. Once localized to membranes, LRRK2 then influences downstream events, evidenced by changes in the autophagy–lysosome pathway. Here, I...

View article titled, Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease

Articles

Autophagic degradation of peroxisomes in mammals

Katarzyna Zientara-Rytter, Suresh Subramani

Biochem Soc Trans (2016) 44 (2): 431–440.

DOI: https://doi.org/10.1042/BST20150268

Published: 11 April 2016

... homoeostasis imbalance, the dynamics of peroxisomes have been widely examined. The increasing volume of reports demonstrating significant involvement of the autophagy machinery in peroxisome removal leads us to summarize current knowledge of peroxisome degradation in mammalian cells. In this review we present...

View article titled, Autophagic degradation of peroxisomes in mammals

Articles

Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae

Hagai Abeliovich, Jörn Dengjel

Biochem Soc Trans (2016) 44 (2): 541–545.

DOI: https://doi.org/10.1042/BST20150278

Published: 11 April 2016

... on evolutionarily conserved pathways. * To whom correspondence should be addressed (email ahagai@agri.huji.ac.il ). 25 1 2016 © 2016 Authors; published by Portland Press Limited 2016 autophagy degradation mitochondria stress response Mitochondria perform a variety of essential...

View article titled, Mitophagy as a stress response in mammalian cells and in respiring S. cerevisiae

Articles

Oncosuppressive functions of tribbles pseudokinase 3

María Salazar, Mar Lorente, Alba Orea-Soufi, David Dávila, Tatiana Erazo, José Lizcano, Arkaitz Carracedo, Endre Kiss-Toth, Guillermo Velasco

Biochem Soc Trans (2015) 43 (5): 1122–1126.

DOI: https://doi.org/10.1042/BST20150124

Published: 09 October 2015

... models of cancer autophagy cannabinoids endoplasmic reticulum (ER) stress tribbles pseudokinases Pseudokinases are a sub-type of protein kinases lacking at least one of the conserved catalytic residues present in their kinase domain. As a consequence, these proteins exhibit very low levels...

View article titled, Oncosuppressive functions of tribbles pseudokinase 3

Articles

TSPO is a REDOX regulator of cell mitophagy

Jemma Gatliff, Michelangelo Campanella

Biochem Soc Trans (2015) 43 (4): 543–552.

DOI: https://doi.org/10.1042/BST20150037

Published: 03 August 2015

... autophagy. This review focuses on the current understanding of this pathway and focuses on the interplay with reactive oxygen species (ROS) and the voltage-dependent anion channel (VDAC), to which TSPO binds, in the regulation of cell mitophagy and hence homoeostasis of the mitochondrial network as a whole...

View article titled, TSPO is a REDOX regulator of cell mitophagy

Articles

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive

Teresa M. Ribeiro-Rodrigues, Steve Catarino, Maria J. Pinho, Paulo Pereira, Henrique Girao

Biochem Soc Trans (2015) 43 (3): 471–475.

DOI: https://doi.org/10.1042/BST20150036

Published: 01 June 2015

... autophagy connexin 43 endocytosis gap junction ubiquitin Gap junctions (GJs) are intercellular channels, formed by six subunits of a transmembrane protein called connexin (Cx) that mediate the direct communication between the cytoplasm of adjacent cells. Gap junction intercellular communication...

View article titled, Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive

Articles

Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease

Pilar Rivero-Ríos, Patricia Gómez-Suaga, Belén Fernández, Jesús Madero-Pérez, Andrew J. Schwab, Allison D. Ebert, Sabine Hilfiker

Biochem Soc Trans (2015) 43 (3): 390–395.

DOI: https://doi.org/10.1042/BST20140301

Published: 01 June 2015

... 2015 Biochemical Society 2015 autophagy endocytosis leucine-rich repeat kinase 2 (LRRK2) nicotinic acid adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein Parkinson's disease (PD) is a prominent neurodegenerative disorder without a cure. Mutations in leucine-rich...

View article titled, Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease

Articles

To beat or not to beat: degradation of Cx43 imposes the heart rhythm

Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Pereira, Henrique Girão

Biochem Soc Trans (2015) 43 (3): 476–481.

DOI: https://doi.org/10.1042/BST20150046

Published: 01 June 2015

... junctions (GJ). Cardiomyocytes are the major cell population in the heart, and as cells with low mitotic activity, are highly dependent upon mechanisms of protein degradation. In the heart, both the ubiquitin-proteasome system (UPS) and autophagy participate in the fine-tune regulation of cardiac...

View article titled, To beat or not to beat: degradation of Cx43 imposes the heart rhythm

Articles

Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration

Dale D.O. Martin, Michael R. Hayden

Biochem Soc Trans (2015) 43 (2): 229–234.

DOI: https://doi.org/10.1042/BST20140281

Published: 07 April 2015

... survival, differentiation and now autophagy. Herein, we describe how myristoylation may play a role in autophagy with an emphasis on PTMyr. 1 To whom correspondence should be addressed (email dalem@cmmt.ubc.ca ). 16 10 2014 © The Authors Journal compilation © 2015 Biochemical Society...

View article titled, Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration

Articles

WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics

Simon G. Pfisterer, Daniela Bakula, Alice Cezanne, Horst Robenek, Tassula Proikas-Cezanne

Biochem Soc Trans (2014) 42 (5): 1414–1417.

DOI: https://doi.org/10.1042/BST20140152

Published: 18 September 2014

...Simon G. Pfisterer; Daniela Bakula; Alice Cezanne; Horst Robenek; Tassula Proikas-Cezanne Macroautophagy (autophagy hereafter) is an evolutionarily highly conserved catabolic process activated by eukaryotes in order to counteract cellular starvation. Autophagy leads to bulk degradation...

View article titled, WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics

Articles

Dynamics of autophagosome formation: a pulse and a sequence of waves

Nicholas T. Ktistakis, Eleftherios Karanasios, Maria Manifava

Biochem Soc Trans (2014) 42 (5): 1389–1395.

DOI: https://doi.org/10.1042/BST20140183

Published: 18 September 2014

... gaps in our knowledge that need additional work. 1 To whom correspondence should be addressed (email nicholas.ktistakis@babraham.ac.uk ) . 2 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 autophagy mammalian (or mechanistic) target of rapamycin...

View article titled, Dynamics of autophagosome formation: a pulse and a sequence of waves

Articles

WIPI2b and Atg16L1: setting the stage for autophagosome formation

Michael I. Wilson, Hannah C. Dooley, Sharon A. Tooze

Biochem Soc Trans (2014) 42 (5): 1327–1334.

DOI: https://doi.org/10.1042/BST20140177

Published: 18 September 2014

...Michael I. Wilson; Hannah C. Dooley; Sharon A. Tooze The double-membraned autophagosome organelle is an integral part of autophagy, a process that recycles cellular components by non-selectively engulfing and delivering them to lysosomes where they are digested. Release of metabolites from...

View article titled, WIPI2b and Atg16L1: setting the stage for autophagosome formation

Includes: Supplementary data

Articles

Motoneuronal and muscle-selective removal of ALS-related misfolded proteins

Valeria Crippa, Mariarita Galbiati, Alessandra Boncoraglio, Paola Rusmini, Elisa Onesto, Elisa Giorgetti, Riccardo Cristofani, Arianna Zito, Angela Poletti

Biochem Soc Trans (2013) 41 (6): 1598–1604.

DOI: https://doi.org/10.1042/BST20130118

Published: 20 November 2013

.... When we compared the potential mutSOD1 toxicity in motoneuron (NSC34) and muscle (C2C12) cells, we found that muscle ALS models possess much higher chymotryptic proteasome activity and autophagy power than motoneuron ALS models. As a result, mutSOD1 molecular behaviour was found to be very different...

View article titled, Motoneuronal and muscle-selective removal of ALS-related misfolded proteins

Articles

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Jaime L. Schneider, Ana Maria Cuervo

Biochem Soc Trans (2013) 41 (6): 1483–1488.

DOI: https://doi.org/10.1042/BST20130126

Published: 20 November 2013

... and that their failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as ‘saviour’ and ‘victim’ in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic...

View article titled, Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Articles

Autophagy and mammalian development

Xiaoting Wu, Hyeran Won, David C. Rubinsztein

Biochem Soc Trans (2013) 41 (6): 1489–1494.

DOI: https://doi.org/10.1042/BST20130185

Published: 20 November 2013

...Xiaoting Wu; Hyeran Won; David C. Rubinsztein Autophagy is a highly conserved cytoplasmic degradation pathway that has an impact on many physiological and disease states, including immunity, tumorigenesis and neurodegeneration. Recent studies suggest that autophagy may also have important functions...

View article titled, Autophagy and mammalian development

Articles

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Joel E. Beevers, Tara M. Caffrey, Richard Wade-Martins

Biochem Soc Trans (2013) 41 (6): 1503–1508.

DOI: https://doi.org/10.1042/BST20130194

Published: 20 November 2013

... (α-synuclein) multiplication and idiopathic PD. In some cases, isogenic control lines have been created to minimize inherent variability between lines from different individuals. Disruptions in autophagy, mitochondrial function and dopamine biology at the synapse have been described. Future...

View article titled, Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Articles

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Sovan Sarkar

Biochem Soc Trans (2013) 41 (5): 1103–1130.

DOI: https://doi.org/10.1042/BST20130134

Published: 23 September 2013

...Sovan Sarkar Autophagy is an intracellular degradation pathway essential for cellular and energy homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles, as well as recycling of cytosolic components during starvation to compensate for nutrient deprivation...

View article titled, Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Articles

WIPI β-propellers in autophagy-related diseases and longevity

Daniela Bakula, Zsuzsanna Takacs, Tassula Proikas-Cezanne

Biochem Soc Trans (2013) 41 (4): 962–967.

DOI: https://doi.org/10.1042/BST20130039

Published: 18 July 2013

...Daniela Bakula; Zsuzsanna Takacs; Tassula Proikas-Cezanne Autophagy is a catabolic pathway in which the cell sequesters cytoplasmic material, including long-lived proteins, lipids and organelles, in specialized double-membrane vesicles, called autophagosomes. Subsequently, autophagosomes...

View article titled, WIPI β-propellers in autophagy-related diseases and longevity

Articles

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

Elaine A. Dunlop, Andrew R. Tee

Biochem Soc Trans (2013) 41 (4): 939–943.

DOI: https://doi.org/10.1042/BST20130030

Published: 18 July 2013

... of the cell and appropriately dictates whether the cell will actively favour energy- and amino-acid-consuming anabolic processes such as cellular growth, or energy- and amino-acid-generating catabolic processes such as autophagy. The present review discusses important feedback mechanisms between these three...

View article titled, The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

Articles

Molecular basis of Charcot–Marie–Tooth type 2B disease

Cecilia Bucci, Maria De Luca

Biochem Soc Trans (2012) 40 (6): 1368–1372.

DOI: https://doi.org/10.1042/BST20120197

Published: 21 November 2012

... possible hypotheses in order to explain how alterations of Rab7 function lead to CMT2B. 1 To whom correspondence should be addressed (email cecilia.bucci@unisalento.it ). 2 8 2012 © 2012 The Authors Journal 2012 autophagy Charcot–Marie–Tooth disease endocytosis peripheral...

View article titled, Molecular basis of Charcot–Marie–Tooth type 2B disease

Articles

Cellular effects of LRRK2 mutations

Mark R. Cookson

Biochem Soc Trans (2012) 40 (5): 1070–1073.

DOI: https://doi.org/10.1042/BST20120165

Published: 19 September 2012

... is needed to understand them in more depth. 1 email cookson@mail.nih.gov 29 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy cell death inclusion body leucine-rich repeat kinase 2 (LRRK2) neurite Parkinson's disease...

View article titled, Cellular effects of LRRK2 mutations

Articles

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2

Youren Tong, Jie Shen

Biochem Soc Trans (2012) 40 (5): 1042–1046.

DOI: https://doi.org/10.1042/BST20120112

Published: 19 September 2012

... as well as impaired dopamine D 2 receptor-mediated functions. Whereas LRRK2 −/− brains are normal, LRRK2 −/− kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy–lysosomal pathway, and increases in apoptotic cell...

View article titled, Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2

Articles

Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins

Shani Bialik, Adi Kimchi

Biochem Soc Trans (2012) 40 (5): 1052–1057.

DOI: https://doi.org/10.1042/BST20120155

Published: 19 September 2012

...@weizmann.ac.il ). 19 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy autophosphorylation DAPK (death-associated protein kinase) leucine-rich repeat kinase 2 (LRRK2) The ROCO proteins are defined by predicted sequence similarity within two domains...

View article titled, Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins

Articles

LRRK2 and autophagy: a common pathway for disease

Claudia Manzoni

Biochem Soc Trans (2012) 40 (5): 1147–1151.

DOI: https://doi.org/10.1042/BST20120126

Published: 19 September 2012

... LRRK2 and autophagy. Implications of this set of data for our understanding of LRRK2′s role in physiology and disease are discussed in the present paper. 1 email c.manzoni@ucl.ac.uk 2 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy...

View article titled, LRRK2 and autophagy: a common pathway for disease

Articles

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models

Maximilian Sloan, Javier Alegre-Abarrategui, Richard Wade-Martins

Biochem Soc Trans (2012) 40 (5): 1080–1085.

DOI: https://doi.org/10.1042/BST20120151

Published: 19 September 2012

... correspondence should be addressed (email javier.alegre@dpag.ox.ac.uk ). 25 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy cytoskeleton dopamine leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease tau Mutations in the LRRK2 (leucine-rich...

View article titled, Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models

Articles

Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease

José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Mireia Niso-Santano, Elisa Pizarro-Estrella, Rosa A. González-Polo, José M. Fuentes

Biochem Soc Trans (2012) 40 (5): 1129–1133.

DOI: https://doi.org/10.1042/BST20120095

Published: 19 September 2012

... of autophagy regulation. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damaged proteins and cytoplasmic organelles. In the present paper, we discuss the role of LRRK2 in autophagy, and the importance of this relationship in the development of nigral degeneration in PD...

View article titled, Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease

Articles

Potential neuroprotective strategies against tauopathy

Jeanna M. Wheeler, Chris R. Guthrie, Brian C. Kraemer

Biochem Soc Trans (2012) 40 (4): 656–660.

DOI: https://doi.org/10.1042/BST20120017

Published: 20 July 2012

... for treatment of various tauopathies. In the present paper, we summarize data regarding characterization of MSUT2 (mammalian suppressor of tau pathology 2), a protein identified in a C. elegans tauopathy model and subsequently shown to modify tau toxicity in mammalian cell culture via the effects on autophagy...

View article titled, Potential neuroprotective strategies against tauopathy

Articles

Degradation of tau protein by autophagy and proteasomal pathways

Yipeng Wang, Eckhard Mandelkow

Biochem Soc Trans (2012) 40 (4): 644–652.

DOI: https://doi.org/10.1042/BST20120071

Published: 20 July 2012

... on the UPS (ubiquitin–proteasome system) and the ALS (autophagy–lysosome system). In the present paper, we focus on the regulation of the degradation of tau by the UPS and ALS and its relation to tau aggregation. We anticipate that stimulation of these two protein-degradation systems might be a potential...

View article titled, Degradation of tau protein by autophagy and proteasomal pathways

Articles

How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal

Nicholas T. Ktistakis, Maria Manifava, Priya Schoenfelder, Sergio Rotondo

Biochem Soc Trans (2012) 40 (1): 37–43.

DOI: https://doi.org/10.1042/BST20110684

Published: 19 January 2012

...Nicholas T. Ktistakis; Maria Manifava; Priya Schoenfelder; Sergio Rotondo The simple phosphoinositide PtdIns3 P has been shown to control cell growth downstream of amino acid signalling and autophagy downstream of amino acid withdrawal. These opposing effects depend in part on the existence...

View article titled, How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal

Articles

Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?

Belém Sampaio-Marques, Carolina Felgueiras, Alexandra Silva, Fernando Rodrigues, Paula Ludovico

Biochem Soc Trans (2011) 39 (5): 1466–1470.

DOI: https://doi.org/10.1042/BST0391466

Published: 21 September 2011

...Belém Sampaio-Marques; Carolina Felgueiras; Alexandra Silva; Fernando Rodrigues; Paula Ludovico Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy...

View article titled, Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?

Articles

Mitophagy, mitochondrial dynamics and the general stress response in yeast

Matthias Müller, Andreas S. Reichert

Biochem Soc Trans (2011) 39 (5): 1514–1519.

DOI: https://doi.org/10.1042/BST0391514

Published: 21 September 2011

...Matthias Müller; Andreas S. Reichert Autophagy is a fundamental cellular process promoting survival under various environmental stress conditions. Selective types of autophagy have gained much interest recently as they are involved in specific quality control mechanisms removing, for example...

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Bacteria in the pathogenesis of inflammatory bowel disease

Paul Flanagan, Barry J. Campbell, Jonathan M. Rhodes

Biochem Soc Trans (2011) 39 (4): 1067–1072.

DOI: https://doi.org/10.1042/BST0391067

Published: 20 July 2011

... Biochemical Society 2011 autophagy Crohn's disease dysbiosis microbiota ulcerative colitis UC (ulcerative colitis) and Crohn's disease are the two predominant phenotypes of IBD (inflammatory bowel disease). Crohn's disease can cause transmural inflammation, affect any part...

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A longer and healthier life with TOR down-regulation: genetics and drugs

Ivana Bjedov, Linda Partridge

Biochem Soc Trans (2011) 39 (2): 460–465.

DOI: https://doi.org/10.1042/BST0390460

Published: 22 March 2011

... with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...

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Articles

Storage problems in lysosomal diseases

Jean Michel Heard, Julie Bruyère, Elise Roy, Stéphanie Bigou, Jérôme Ausseil, Sandrine Vitry

Biochem Soc Trans (2010) 38 (6): 1442–1447.

DOI: https://doi.org/10.1042/BST0381442

Published: 24 November 2010

.... 1 To whom correspondence should be addressed (email jmheard@pasteur.fr ). 26 4 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 autophagy Golgi matrix protein 130 (GM130) lysosomal storage disease (LSD) lysosome-associated membrane protein (LAMP...

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