... HGF/MET signaling is a driver of many cancers and contributes to drug resistance to several approved therapeutics targeting other RTKs, making MET itself an important drug target. In RTKs, homeostatic receptor signaling is dependent on autoinhibition in the absence of ligand binding and orchestrated...

... for the autoinhibition of CHMP3 ( Figure 1 ). The ESCRT (endosomal sorting complex required for transport) pathway consists of a network of class E Vps (vacuolar protein sorting) proteins that is required for the biogenesis of MVBs (multivesicular bodies) and for the sorting of ubiquitinated cargo...

...: autoinhibition, calmodulin, cytochrome c, electron transfer, nitric oxide, reductase domain. Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain; nNOStr, nNOS truncation mutant; H4B, (6R)-5,6,7,8-tetrahydro-l...