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Keywords: autoimmunity
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Biochem Soc Trans (2020) 48 (5): 2273–2281.
Published: 01 September 2020
.... Modifying the adaptive immune response to ApoB holds promise for preventing atherosclerosis and reducing disease burden. atherosclerosis autoimmunity immunology Atherosclerosis is a disease of the arterial wall. Predilection sites are characterized by oscillatory or disturbed flow [ 1...
Biochem Soc Trans (2015) 43 (4): 745–751.
Published: 03 August 2015
... and alteration of these metabolic processes coincides with immune cell dysfunction as is evident in atherosclerosis, cancer and autoimmunity. Indeed, membrane lipid composition is emerging as an important factor influencing the ability of cells to respond appropriately to microenvironmental stimuli. Consequently...
Biochem Soc Trans (2014) 42 (6): 1524–1528.
Published: 17 November 2014
... with autoimmune diseases are PKCθ-dependent. PKCθ-deficient mice are either resistant to or show markedly reduced symptoms in models of MS (multiple sclerosis), IBD (inflammatory bowel disease), arthritis and asthma. Thus potent and selective inhibition of PKCθ has the potential to block T-cell-mediated...
Includes: Supplementary data
Biochem Soc Trans (2011) 39 (4): 1086–1091.
Published: 20 July 2011
... 3) and apoptosis signalling cascades. The phenotype of mice with full or conditional A20 deletion illustrates that A20 expression is essential to prevent chronic inflammation and autoimmune pathology. In addition, polymorphisms within the A20 genomic locus have been associated with multiple...
Biochem Soc Trans (2007) 35 (2): 177–180.
Published: 20 March 2007
... isoforms. I discuss gene disruption studies in mice that reveal redundant or limited roles for individual isoforms, along with evidence for potential autoimmunity when class IA PI3K signalling is reduced. © 2007 The Biochemical Society 2007 autoimmunity knockout mouse phosphoinositide 3-kinase...
Biochem Soc Trans (2006) 34 (6): 1032–1036.
Published: 25 October 2006
... is high in effector sites and drives uncontrolled inflammation. Similarly, we believe that initiation of autoimmune inflammation is initiated by the liberation of inflammatory signals due to infection or trauma. In this review, we highlight some of the molecules responsible for maintaining an activated T...