... Society 2009 angiogenesis arachidonic acid cyclo-oxygenase (COX) endothelial cell prostanoid protease-activated receptor (PAR) Figure 1 Synthesis of prostanoids Activation of GPCRs including PAR-1 and PAR-2 [ 2 , 3 ], as well as growth factor receptors (e.g. VEGF receptors; [ 2 , 4...

... arachidonic acid cascade. Upon chronic administration, lithium and carbamazepine decrease the binding activity of activator protein-2 and, in turn, the transcription, translation and activity of its arachidonic acid-selective calcium-dependent phospholipase A 2 gene product, whereas chronic valproic acid non...

...Jaffar Nourooz-Zadeh A large body of evidence indicates that measurement of F 2 -isoprostanes, specific prostaglandin F 2 -like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F 2...

.... In the present review, we focus on exogenous and endogenous effects of NEFAs, including the polyunsaturated fatty acid, arachidonic acid (or its metabolites generated from cyclo-oxygenase activity), on β-cell metabolism, and have explored the outcomes with respect to β-cell insulin secretion. 1 To whom...

...P.C. Calder The n –6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n –3 polyunsaturated fatty acids (found in oily...

...-known, and apparently ubiquitous, store-operated mechanism, subsequent studies suggested that this was unlikely. It is now known that, in many cell types, a novel non-capacitative Ca 2+ -selective pathway whose activation is dependent on arachidonic acid is responsible, and the channels involved [ARC...

... Porphyridium cruentum are rich in arachidonic acid (AA, 20: 4 ω 6) and eicosapentaenoic acid (EPA, 20: 5 ω 3). A mutant of this alga, impaired of growth at suboptimal temperatures, was shown to have reduced levels of EPA and of the eukaryotic molecular species of monogalactosyldiacylglycerol (MGDG...

... be addressed (e-mail jon.napier@bbsrc.ac.uk ) 30 6 2000 © 2000 Biochemical Society 2000 arachidonic acid desaturase fatty acid elongation PUFA, polyunsaturated fatty acid ORF, open reading frame Fatty Acid Biosynthesis: Elongation Production of C,, polyunsaturated fatty acids...