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Keywords: apoptosis
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Articles
Biochem Soc Trans (2022) 50 (3): 1105–1118.
Published: 19 May 2022
... interactions to signal apoptosis. Fas/CD95 death receptor-mediated apoptosis requires the formation of the so-called d eath- i nducing s ignaling c omplex (DISC), bringing together Fas/CD95, Fas-associated death domain-containing protein and procaspase-8. In the last two decades, cholesterol-rich lipid raft...
Articles
Biochem Soc Trans (2022) 50 (2): 839–851.
Published: 28 March 2022
... monoclonal antibody was recently shown to increase the susceptibility of several pancreatic cancer cell lines to chemotherapeutics, increase their apoptosis, and decrease their migration. MMP-7 activities are most apparent at the surfaces of innate immune, epithelial, and tumor cells. Proteolytic shedding...
Articles
Biochem Soc Trans (2022) 50 (1): 13–20.
Published: 15 February 2022
... can contribute to autoinflammatory and autoimmune diseases or life-threatening conditions like sepsis. These diseases generally display increased levels of cell death, which, downstream of the TNF receptor, can either be caspase-dependent (apoptosis) or caspase-independent (necroptosis). Significant...
Articles
Biochem Soc Trans (2021) 49 (6): 2787–2795.
Published: 16 December 2021
...Zheng Yuan; Grant Dewson; Peter E. Czabotar; Richard W. Birkinshaw The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein–protein interactions within...
Articles
Biochem Soc Trans (2021) 49 (5): 2397–2410.
Published: 28 September 2021
...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...
Articles
Biochem Soc Trans (2021) 49 (5): 2381–2395.
Published: 13 September 2021
... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis BCL-2 BCL-XL BH3-mimetics MCL-1 The BCL-2 family of proteins consists of functionally opposing, though structurally related proteins [ 1 ]. The founding...
Articles
Biochem Soc Trans (2021) 49 (2): 793–804.
Published: 12 April 2021
... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis cell clearance necroptosis necrosis phagocytosis pyroptosis For over 50 years apoptosis has dominated basic and translational research in the cell death field...
Articles
Biochem Soc Trans (2021) 49 (2): 663–674.
Published: 11 March 2021
... of intermembrane space proteins like cytochrome c , is considered a point of no return in apoptosis. MOMP is controlled by the proteins of the B-cell lymphoma 2 (BCL-2) family, including pro-and anti-apoptotic members, whose balance determines the decision between cell death and survival. Other factors...
Articles
Biochem Soc Trans (2020) 48 (5): 2079–2088.
Published: 01 September 2020
... (ApoBDs), a distinct type of EVs released by cells undergoing a form of programmed cell death called apoptosis, has been largely unexplored. Recent studies have shed light on ApoBD biogenesis and functions, promisingly implicating their therapeutic potential. In this review, we discuss many strategies...
Articles
Biochem Soc Trans (2020) 48 (2): 719–731.
Published: 08 April 2020
... different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cells, thus they can be potential sources as chemotherapeutic agents...
Articles
Biochem Soc Trans (2017) 45 (6): 1213–1223.
Published: 20 October 2017
... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis...
Articles
Biochem Soc Trans (2017) 45 (1): 123–129.
Published: 15 February 2017
... of an inhibitory function of wild-type LRRK2, or a combination of the two, expands the landscape of potential therapeutic targets for future intervention in the clinic. Correspondence: Hardy J. Rideout ( hrideout@bioacademy.gr ) 17 8 2016 11 10 2016 14 10 2016 apoptosis leucine-rich...
Articles
Biochem Soc Trans (2016) 44 (5): 1531–1540.
Published: 19 October 2016
... partner binding and reduce susceptibility to cell death [ 18 , 34 ]. In other words, HKs appear to compete with Bcl-2 family members for VDAC binding. In response to apoptosis initiation, mitochondria will release apoptogenic factors, such as cytochrome c (cyt c ), in the cytoplasm, directing further...
Articles
Biochem Soc Trans (2015) 43 (4): 531–536.
Published: 03 August 2015
... Limited 2015 apoptosis drug design glioblastoma translocator protein The up-regulation of TSPO in GM and the correlation between TSPO levels, GM malignancy and clinical outcome has sparked investigation of TSPO as a GM therapeutic target. Several lines of evidence have revealed...
Articles
Biochem Soc Trans (2015) 43 (4): 715–719.
Published: 03 August 2015
... the implications of these interactions in the progression of cardiovascular infection. 1 To whom correspondence should be addressed (email skerrigan@rcsi.ie ) . 30 4 2015 © 2015 Authors; published by Portland Press Limited 2015 apoptosis endothelial cells endothelial dysfunction...
Articles
Biochem Soc Trans (2015) 43 (4): 720–726.
Published: 03 August 2015
... platelets reach as forerunners and function as critical players. 1 To whom correspondence should be addressed (email meinrad.gawaz@med.uni-tuebingen.de ) . 12 5 2015 © 2015 Authors; published by Portland Press Limited 2015 apoptosis coronary artery disease (CAD) CXCR4 CXCR7...
Articles
Biochem Soc Trans (2015) 43 (3): 323–327.
Published: 01 June 2015
... shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can...
Articles
Biochem Soc Trans (2015) 43 (2): 297–301.
Published: 07 April 2015
... Journal compilation © 2015 Biochemical Society 2015 apoptosis endoplasmic reticulum (ER)-mitochondria contacts mitophagy mitochondrial dynamics phosphatase and tensin homologue-induced putative kinase 1 (PINK1) Parkin There is growing evidence that the ER-mitochondria interface...
Articles
Biochem Soc Trans (2015) 43 (2): 229–234.
Published: 07 April 2015
... cleavage. It promotes membrane binding and relocalization of functional protein domains released by caspase cleavage during apoptosis, or programmed cell death. However, as the requirement of caspase cleavage has expanded beyond just cell death, it has become apparent that PTMyr may play a role in cell...
Articles
Biochem Soc Trans (2014) 42 (6): 1519–1523.
Published: 17 November 2014
... is to pinpoint the underlying key factors and to develop therapies for their direct targeting. Protein kinase C (PKC) enzymes are promising candidates, as some PKCs were shown to be involved in regulation of apoptosis. Our studies and others have shown that PKCη is an anti-apoptotic kinase, able to confer...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
...Margaret M. Briehl; Margaret E. Tome; Sarah T. Wilkinson; Melba C. Jaramillo; Kristy Lee Characteristics of cancer cells include a more oxidized redox environment, metabolic reprogramming and apoptosis resistance. Our studies with a lymphoma model have explored connections between the cellular...
Articles
Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
...Julea N. Butt Apoptosis is triggered by an accumulation of ROS (reactive oxygen species) produced by proteins of the mitochondrial respiratory chain. The levels of ROS are controlled by the activities of mitochondrial redox proteins such as glutaredoxin 2 that help to modulate the susceptibility...
Articles
Biochem Soc Trans (2014) 42 (1): 125–129.
Published: 23 January 2014
... explanations for this. Figure 1 Strategies to treat ovarian cancer Potential drug targets are shown in green, and drugs are shown in blue. Autotaxin drives the production of LPA from lysophosphatidylcholine (LPC) which activates survival pathways to suppress chemotherapy-induced apoptosis. Cells...
Articles
Biochem Soc Trans (2013) 41 (2): 657–663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Articles
Biochem Soc Trans (2011) 39 (5): 1376–1381.
Published: 21 September 2011
... apoptosis in endothelial cells. These findings provide a novel mechanism by which ADI inhibits tumour angiogenesis through modulating endothelial tip cells. 1 To whom correspondence should be addressed (email yluo@tsinghua.edu.cn ). 18 6 2011 © The Authors Journal compilation © 2011...
Includes: Supplementary data
Articles
Biochem Soc Trans (2011) 39 (5): 1461–1465.
Published: 21 September 2011
... proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field. 1 To whom correspondence should be addressed (email Cristina.mazzoni@uniroma1.it ). 10 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis...
Articles
Biochem Soc Trans (2011) 39 (5): 1499–1501.
Published: 21 September 2011
...Birthe Fahrenkrog The baker's yeast, Saccharomyces cerevisiae , is also capable of undergoing programmed cell death or apoptosis, for example in response to viral infection as well as during chronological and replicative aging. Intrinsically, programmed cell death in yeast can be induced...
Articles
Biochem Soc Trans (2011) 39 (5): 1502–1508.
Published: 21 September 2011
...@exeter.ac.uk ). 17 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis caspase necrosis programmed cell death (PCD) protease Saccharomyces cerevisiae Understanding the molecular mechanisms regulating and executing PCD (programmed cell death...
Articles
Biochem Soc Trans (2011) 39 (5): 1527–1532.
Published: 21 September 2011
... are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that induce apoptosis. Their antifungal spectrum, mode of action and toxicity are discussed in more detail. 1 To whom correspondence should be addressed...
Articles
Biochem Soc Trans (2011) 39 (5): 1533–1537.
Published: 21 September 2011
...Maria João Sousa; Flávìa Azevedo; Ana Pedras; Carolina Marques; Olga P. Coutinho; Ana Preto; Hernâni Gerós; Susana R. Chaves; Manuela Côrte-Real The yeast apoptosis field emerged with the finding that key components of the apoptotic machinery are conserved in these simple eukaryotes. Thus it became...
Articles
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
... species) can be produced under the stimulus of different cytokines such as TNFα (tumour necrosis factor α). It has been shown in different experimental models that they are also able to regulate apoptosis and other cellular processes. The status of oxidative stress elements in Crohn's disease...
Articles
Biochem Soc Trans (2011) 39 (1): 349–354.
Published: 19 January 2011
... of the infected cells. The present article focuses on possible underlying mechanisms for glycosylation changes in the uroepithelial cell receptors for FimH. Like diabetes, bacterial adhesion induces apoptosis that may bring the endoplasmic reticulum membrane with immature mannosylated glycoproteins to the surface...
Articles
Biochem Soc Trans (2010) 38 (6): 1571–1575.
Published: 24 November 2010
... and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia. miRNA-based therapeutic approaches to treat cancer are emerging. Bcl2 is highly regulated by miRNAs and is therefore an excellent candidate for such approaches. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2009) 37 (1): 200–203.
Published: 20 January 2009
...Anne-Laure Mahul-Mellier; Flavie Strappazzon; Christine Chatellard-Causse; Béatrice Blot; David Béal; Sakina Torch; Fiona Hemming; Anne Petiot; Jean-Marc Verna; Sandrine Fraboulet; Rémy Sadoul Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first...
Articles
Biochem Soc Trans (2009) 37 (1): 137–142.
Published: 20 January 2009
.... 1 To whom correspondence should be addressed (email stenmark@ulrik.uio.no ). 17 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 apoptosis endosomal sorting complex required for transport (ESCRT) growth factor receptor Notch tumour suppressor...
Articles
Biochem Soc Trans (2008) 36 (6): 1472–1477.
Published: 19 November 2008
... and apoptosis [ 7 , 9 ]. One family of multivalent lectins that can organize cell-surface microdomains or lattices is the galectins [ 7 ]. The galectins are a family of animal lectins that share a common CRD (carbohydrate recognition domain). There are structural subfamilies of galectins, but all galectins...
Articles
Biochem Soc Trans (2008) 36 (5): 959–962.
Published: 19 September 2008
... regulation of this pathway may be involved in mediating their effects on viability. 1 To whom correspondence should be addressed (email noel.morgan@pms.ac.uk ). 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis eukaryotic initiation factor 2α...
Articles
Biochem Soc Trans (2008) 36 (5): 905–908.
Published: 19 September 2008
...Noel G. Morgan; Shalinee Dhayal; Eleftheria Diakogiannaki; Hannah J. Welters Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence...
Articles
Biochem Soc Trans (2008) 36 (5): 963–965.
Published: 19 September 2008
...Anath Shalev Glucotoxicity plays a major role in pancreatic β-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic β-cell factor that is induced by glucose...
Articles
Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... autophagic, or type II) that is characterized by the massive accumulation of autophagosomes. Regulators of apoptosis (e.g. Bcl-2 family members) also modulate autophagy, suggesting an intimate cross-talk between these two degradative pathways. It is still unclear whether autophagic vacuolization has...
Articles
Biochem Soc Trans (2008) 36 (5): 909–915.
Published: 19 September 2008
... © 2008 Biochemical Society 2008 apoptosis diabetes endoplasmic reticulum stress (ER stress) insulin lipotoxicity pancreatic β-cell The ER stress response is an important adaptive cellular signalling response in cells with high secretory activity. It aims to balance secretory...
Articles
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
... in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult...
Articles
Biochem Soc Trans (2008) 36 (3): 348–352.
Published: 21 May 2008
... individuals. NEFAs cause β-cell apoptosis and may thus contribute to progressive β-cell loss in Type 2 diabetes. The molecular pathways and regulators involved in NEFA-mediated β-cell dysfunction and apoptosis are beginning to be understood. We have identified ER (endoplasmic reticulum) stress as one...
Articles
Biochem Soc Trans (2008) 36 (3): 290–293.
Published: 21 May 2008
... islets, and the regulatory role of insulin in protecting against β-cell apoptosis. We have identified mRNAs encoding IRs (insulin receptors) and downstream signalling elements in dissociated human islet β-cells by single-cell RT (reverse transcription)–PCR, and perifusion studies have indicated...
Articles
Biochem Soc Trans (2008) 36 (3): 321–327.
Published: 21 May 2008
...Decio L. Eizirik; Fabrice Moore; Daisy Flamez; Fernanda Ortis Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that β-cell apoptosis depends on the parallel...
Articles
Biochem Soc Trans (2008) 36 (3): 334–339.
Published: 21 May 2008
... and TNFα mediate activation of the transcription factor NF-κB (nuclear factor κB) pathway. Use of a degradation-resistant NF-κB protein inhibitor (ΔNIκBα), specifically expressed in β-cells, significantly reduced IL-1β+IFN-γ-induced apoptosis. Moreover, in vivo , it protected against multiple low-dose...
Articles
Biochem Soc Trans (2008) 36 (3): 340–342.
Published: 21 May 2008
.... Ritzel R. Rizza R.A. Butler P.C. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes Diabetes 2003 52 102 110 19 Yoon K.H. Ko S.H. Cho J.H. Lee J.M. Ahn Y.B. Song K.H. Yoo S.J. Kang M.I. Cha B.Y. Lee K.W...
Articles
Biochem Soc Trans (2008) 36 (1): 1–9.
Published: 22 January 2008
...Susan E. Logue; Seamus J. Martin Apoptosis, a highly controlled mode of cell death, is utilized to eliminate superfluous, aged, injured or infected cells from the body. Caspases, a family of aspartic acid-specific proteases, are the major effectors of apoptosis. To curtail their activity, caspases...
Articles
Biochem Soc Trans (2007) 35 (5): 1001–1004.
Published: 25 October 2007
... focused on understanding the molecular mechanisms through which PKCδ regulates apoptosis and on how the pro-apoptotic activity of this ubiquitous kinase is regulated such that cells only activate the apoptotic cascade when appropriate. We have identified multiple regulatory steps that activate the pro...
Articles
Biochem Soc Trans (2007) 35 (5): 1372–1374.
Published: 25 October 2007
... appropriate inhibitors to identify stage-specific events. We have adopted this approach to study a group of benzyl- O - N -acetyl- D -galactosamine analogues in human colorectal cancer cell lines. Exposure to O-glycan inhibitors resulted in the induction of apoptosis, a block in proliferation, accumulation...