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Articles

Messenger functions of cell death during development and homeostasis

Loic Fort

Biochem Soc Trans (2023) 51 (2): 759–769.

DOI: https://doi.org/10.1042/BST20220925

Published: 06 April 2023

... Press Limited on behalf of the Biochemical Society 2023 apoptosis cell death cell homeostasis developmental biology purinergic signaling Cell death is a general term referring to the functional end of cellular activities, as a result of damage or in response to physiological signals...

View article titled, Messenger functions of cell death during development and homeostasis

Articles

Mitochondrial DNA in cell death and inflammation

In Collection

Cell death and survival

Rosalie Heilig, Jordan Lee, Stephen W.G. Tait

Biochem Soc Trans (2023) 51 (1): 457–472.

DOI: https://doi.org/10.1042/BST20221525

Published: 23 February 2023

... imparts the organelle with its own double stranded, circular genome able to replicate, in the matrix, independently of the nuclear genome [ 3 ]. Mitochondria are essential for mitochondrial (intrinsic) apoptosis. Particularly during extrinsic apoptosis [ 4–8 ] and intracellular death complexes [ 9–12...

View article titled, Mitochondrial DNA in cell death and inflammation

Articles

Inflammatory cell death: how macrophages sense neighbouring cell infection and damage

Xiaohui Wang, Larisa I. Labzin

Biochem Soc Trans (2023) 51 (1): 303–313.

DOI: https://doi.org/10.1042/BST20220807

Published: 25 January 2023

...Xiaohui Wang; Larisa I. Labzin Programmed cell death is a critical host defence strategy during viral infection. Neighbouring cells deal with this death in distinct ways depending on how the infected cell dies. While apoptosis is considered immunologically silent, the lytic pathways of necroptosis...

View article titled, Inflammatory cell death: how macrophages sense neighbouring cell infection and damage

Articles

Therapeutic targeting of TRAIL death receptors

In Collection

Cell death and survival

Francesca Di Cristofano, Andrew George, Vida Tajiknia, Maryam Ghandali, Laura Wu, Yiqun Zhang, Praveen Srinivasan, Jillian Strandberg, Marina Hahn, Ashley Sanchez Sevilla Uruchurtu, Attila A. Seyhan, Benedito A. Carneiro, Lanlan Zhou, Kelsey E. Huntington, Wafik S. El-Deiry

Biochem Soc Trans (2023) 51 (1): 57–70.

DOI: https://doi.org/10.1042/BST20220098

Published: 11 January 2023

... necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the development of TRAIL receptor agonists (TRAs), including...

View article titled, Therapeutic targeting of TRAIL death receptors

Articles

RIPK1 and RIPK3 in antibacterial defence

In Collection

Cell death and survival

Hui Wen Yeap, Kaiwen W. Chen

Biochem Soc Trans (2022) 50 (6): 1583–1594.

DOI: https://doi.org/10.1042/BST20211242

Published: 24 November 2022

... inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis, pyroptosis to necroptosis. In this review, we first discuss the mechanisms by which RIPK1 and RIPK3 promote the assembly of death-inducing complexes and how these cell death pathways are activated as host responses...

View article titled, RIPK1 and RIPK3 in antibacterial defence

Articles

Mechanisms of germ cell survival and plasticity in Caenorhabditis elegans

Wei Cao, Roger Pocock

Biochem Soc Trans (2022) 50 (5): 1517–1526.

DOI: https://doi.org/10.1042/BST20220878

Published: 05 October 2022

... BY) . Open access for this article was enabled by the participation of Monash University in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis Caenorhabditis elegans germ cells RNA splicing...

View article titled, Mechanisms of germ cell survival and plasticity in Caenorhabditis elegans

Articles

Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

In Collection

Cell death and survival

Faustino Mollinedo, Consuelo Gajate

Biochem Soc Trans (2022) 50 (3): 1105–1118.

DOI: https://doi.org/10.1042/BST20211115

Published: 19 May 2022

... interactions to signal apoptosis. Fas/CD95 death receptor-mediated apoptosis requires the formation of the so-called d eath- i nducing s ignaling c omplex (DISC), bringing together Fas/CD95, Fas-associated death domain-containing protein and procaspase-8. In the last two decades, cholesterol-rich lipid raft...

View article titled, Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

Articles

MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

Steven R. Van Doren

Biochem Soc Trans (2022) 50 (2): 839–851.

DOI: https://doi.org/10.1042/BST20210640

Published: 28 March 2022

... monoclonal antibody was recently shown to increase the susceptibility of several pancreatic cancer cell lines to chemotherapeutics, increase their apoptosis, and decrease their migration. MMP-7 activities are most apparent at the surfaces of innate immune, epithelial, and tumor cells. Proteolytic shedding...

View article titled, MMP-7 marks severe pancreatic cancer and alters tumor cell signaling by proteolytic release of ectodomains

Articles

A proteomic perspective on TNF-mediated signalling and cell death

In Collection

Cell death and survival

Maria C. Tanzer

Biochem Soc Trans (2022) 50 (1): 13–20.

DOI: https://doi.org/10.1042/BST20211114

Published: 15 February 2022

... can contribute to autoinflammatory and autoimmune diseases or life-threatening conditions like sepsis. These diseases generally display increased levels of cell death, which, downstream of the TNF receptor, can either be caspase-dependent (apoptosis) or caspase-independent (necroptosis). Significant...

View article titled, A proteomic perspective on TNF-mediated signalling and cell death

Articles

VDAC2 and the BCL-2 family of proteins

In Collection

Cell death and survival

Zheng Yuan, Grant Dewson, Peter E. Czabotar, Richard W. Birkinshaw

Biochem Soc Trans (2021) 49 (6): 2787–2795.

DOI: https://doi.org/10.1042/BST20210753

Published: 16 December 2021

...Zheng Yuan; Grant Dewson; Peter E. Czabotar; Richard W. Birkinshaw The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein–protein interactions within...

View article titled, VDAC2 and the BCL-2 family of proteins

Articles

Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

In Collection

Cell death and survival

W. Douglas Fairlie, Erinna F. Lee

Biochem Soc Trans (2021) 49 (5): 2397–2410.

DOI: https://doi.org/10.1042/BST20210750

Published: 28 September 2021

...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...

View article titled, Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers

Articles

Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

In Collection

Cell death and survival

Erinna F. Lee, W. Douglas Fairlie

Biochem Soc Trans (2021) 49 (5): 2381–2395.

DOI: https://doi.org/10.1042/BST20210749

Published: 13 September 2021

... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis BCL-2 BCL-XL BH3-mimetics MCL-1 The BCL-2 family of proteins consists of functionally opposing, though structurally related proteins [ 1 ]. The founding...

View article titled, Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

Articles

Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells

In Collection

Cell death and survival

Georgia K. Atkin-Smith

Biochem Soc Trans (2021) 49 (2): 793–804.

DOI: https://doi.org/10.1042/BST20200696

Published: 12 April 2021

... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis cell clearance necroptosis necrosis phagocytosis pyroptosis For over 50 years apoptosis has dominated basic and translational research in the cell death field...

View article titled, Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells

Articles

Mechanisms of mitochondrial cell death

In Collection

Cell death and survival

Shashank Dadsena, Cristiana Zollo, Ana J. García-Sáez

Biochem Soc Trans (2021) 49 (2): 663–674.

DOI: https://doi.org/10.1042/BST20200522

Published: 11 March 2021

... of intermembrane space proteins like cytochrome c , is considered a point of no return in apoptosis. MOMP is controlled by the proteins of the B-cell lymphoma 2 (BCL-2) family, including pro-and anti-apoptotic members, whose balance determines the decision between cell death and survival. Other factors...

View article titled, Mechanisms of mitochondrial cell death

Articles

Unleashing the therapeutic potential of apoptotic bodies

Thanh Kha Phan, Dilara Ceyda Ozkocak, Ivan Ka Ho Poon

Biochem Soc Trans (2020) 48 (5): 2079–2088.

DOI: https://doi.org/10.1042/BST20200225

Published: 01 September 2020

... (ApoBDs), a distinct type of EVs released by cells undergoing a form of programmed cell death called apoptosis, has been largely unexplored. Recent studies have shed light on ApoBD biogenesis and functions, promisingly implicating their therapeutic potential. In this review, we discuss many strategies...

View article titled, Unleashing the therapeutic potential of apoptotic bodies

Articles

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Jia Jin Hiu, Michelle Khai Khun Yap

Biochem Soc Trans (2020) 48 (2): 719–731.

DOI: https://doi.org/10.1042/BST20200110

Published: 08 April 2020

... different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cells, thus they can be potential sources as chemotherapeutic agents...

View article titled, Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

Articles

Platelet mitochondrial dysfunction and the correlation with human diseases

Li Wang, Qiang Wu, Zhijia Fan, Rufeng Xie, Zhicheng Wang, Yuan Lu

Biochem Soc Trans (2017) 45 (6): 1213–1223.

DOI: https://doi.org/10.1042/BST20170291

Published: 20 October 2017

... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis...

View article titled, Platelet mitochondrial dysfunction and the correlation with human diseases

Articles

Neuronal death signaling pathways triggered by mutant LRRK2

Hardy J. Rideout

Biochem Soc Trans (2017) 45 (1): 123–129.

DOI: https://doi.org/10.1042/BST20160256

Published: 15 February 2017

...); published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis leucine-rich repeat kinase 2 neuronal death In a disease of complex etiology such as Parkinson's disease (PD), the underlying pathology is equally complex; however, the primary motor dysfunction...

View article titled, Neuronal death signaling pathways triggered by mutant LRRK2

Articles

The multiple assemblies of VDAC: from conformational heterogeneity to β-aggregation and amyloid formation

Alexandre Boulbrima, Davina Temple, Georgios Psakis

Biochem Soc Trans (2016) 44 (5): 1531–1540.

DOI: https://doi.org/10.1042/BST20160114

Published: 19 October 2016

.... Correspondence: Georgios Psakis ( g.psakis@hud.ac.uk ) 13 5 2016 22 6 2016 28 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 amyloid formation apoptosis oligomerisation plants protein aggregation VDAC Voltage...

View article titled, The multiple assemblies of VDAC: from conformational heterogeneity to β-aggregation and amyloid formation

Articles

Dysregulation of the endothelium following Staphylococcus aureus infection

Steven W. Kerrigan, Cormac McDonnell

Biochem Soc Trans (2015) 43 (4): 715–719.

DOI: https://doi.org/10.1042/BST20140309

Published: 03 August 2015

... the implications of these interactions in the progression of cardiovascular infection. 1 To whom correspondence should be addressed (email skerrigan@rcsi.ie ) . 30 4 2015 © 2015 Authors; published by Portland Press Limited 2015 apoptosis endothelial cells endothelial dysfunction...

View article titled, Dysregulation of the endothelium following Staphylococcus aureus infection

Articles

TSPO as a target for glioblastoma therapeutics

Eryn L. Werry, Melissa L. Barron, Michael Kassiou

Biochem Soc Trans (2015) 43 (4): 531–536.

DOI: https://doi.org/10.1042/BST20150015

Published: 03 August 2015

... Limited 2015 apoptosis drug design glioblastoma translocator protein Gliomas are a family of highly aggressive brain tumours formed from brain glial cells or their precursors. The most common glioma in adults is glioblastoma multiforme (GM), comprising 60%–70% of all primary brain tumour...

View article titled, TSPO as a target for glioblastoma therapeutics

Articles

Role of chemokine receptors CXCR4 and CXCR7 for platelet function

Madhumita Chatterjee, Dominik Rath, Meinrad Gawaz

Biochem Soc Trans (2015) 43 (4): 720–726.

DOI: https://doi.org/10.1042/BST20150113

Published: 03 August 2015

... platelets reach as forerunners and function as critical players. 1 To whom correspondence should be addressed (email meinrad.gawaz@med.uni-tuebingen.de ) . 12 5 2015 © 2015 Authors; published by Portland Press Limited 2015 apoptosis coronary artery disease (CAD) CXCR4 CXCR7...

View article titled, Role of chemokine receptors CXCR4 and CXCR7 for platelet function

Articles

Post-transcriptional regulation of gene expression by Unr

Swagat Ray, Pól Ó Catnaigh, Emma C. Anderson

Biochem Soc Trans (2015) 43 (3): 323–327.

DOI: https://doi.org/10.1042/BST20140271

Published: 01 June 2015

... shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can...

View article titled, Post-transcriptional regulation of gene expression by Unr

Articles

Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration

Dale D.O. Martin, Michael R. Hayden

Biochem Soc Trans (2015) 43 (2): 229–234.

DOI: https://doi.org/10.1042/BST20140281

Published: 07 April 2015

... cleavage. It promotes membrane binding and relocalization of functional protein domains released by caspase cleavage during apoptosis, or programmed cell death. However, as the requirement of caspase cleavage has expanded beyond just cell death, it has become apparent that PTMyr may play a role in cell...

View article titled, Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration

Articles

The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1–Parkin pathway?

Zoi Erpapazoglou, Olga Corti

Biochem Soc Trans (2015) 43 (2): 297–301.

DOI: https://doi.org/10.1042/BST20150008

Published: 07 April 2015

... Journal compilation © 2015 Biochemical Society 2015 apoptosis endoplasmic reticulum (ER)-mitochondria contacts mitophagy mitochondrial dynamics phosphatase and tensin homologue-induced putative kinase 1 (PINK1) Parkin Parkinson's disease (PD), the most common movement disorder...

View article titled, The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1–Parkin pathway?

Articles

PKCη is an anti-apoptotic kinase that predicts poor prognosis in breast and lung cancer

Udi Zurgil, Assaf Ben-Ari, Noa Rotem-Dai, Galia Karp, Ella Krasnitsky, Sigal A. Frost, Etta Livneh

Biochem Soc Trans (2014) 42 (6): 1519–1523.

DOI: https://doi.org/10.1042/BST20140182

Published: 17 November 2014

... is to pinpoint the underlying key factors and to develop therapies for their direct targeting. Protein kinase C (PKC) enzymes are promising candidates, as some PKCs were shown to be involved in regulation of apoptosis. Our studies and others have shown that PKCη is an anti-apoptotic kinase, able to confer...

View article titled, PKCη is an anti-apoptotic kinase that predicts poor prognosis in breast and lung cancer

Articles

Mitochondria and redox homoeostasis as chemotherapeutic targets

Margaret M. Briehl, Margaret E. Tome, Sarah T. Wilkinson, Melba C. Jaramillo, Kristy Lee

Biochem Soc Trans (2014) 42 (4): 939–944.

DOI: https://doi.org/10.1042/BST20140087

Published: 11 August 2014

...Margaret M. Briehl; Margaret E. Tome; Sarah T. Wilkinson; Melba C. Jaramillo; Kristy Lee Characteristics of cancer cells include a more oxidized redox environment, metabolic reprogramming and apoptosis resistance. Our studies with a lymphoma model have explored connections between the cellular...

View article titled, Mitochondria and redox homoeostasis as chemotherapeutic targets

Articles

New strategies for the treatment of ovarian cancer

Elizabeth Robinson, Natalie Fisher, Vasileios Stamelos, Charles Redman, Alan Richardson

Biochem Soc Trans (2014) 42 (1): 125–129.

DOI: https://doi.org/10.1042/BST20130203

Published: 23 January 2014

... to treat ovarian cancer. 1 These authors contributed equally to this article. 2 To whom correspondence should be addressed (email a.richardson1@keele.ac.uk ). 28 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 apoptosis autotaxin BH3 mimetic...

View article titled, New strategies for the treatment of ovarian cancer

Articles

Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Julea N. Butt

Biochem Soc Trans (2014) 42 (1): 47–51.

DOI: https://doi.org/10.1042/BST20130256

Published: 23 January 2014

...Julea N. Butt Apoptosis is triggered by an accumulation of ROS (reactive oxygen species) produced by proteins of the mitochondrial respiratory chain. The levels of ROS are controlled by the activities of mitochondrial redox proteins such as glutaredoxin 2 that help to modulate the susceptibility...

View article titled, Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Articles

The impact of hypoxia on cell death pathways

Colin R. Lenihan, Cormac T. Taylor

Biochem Soc Trans (2013) 41 (2): 657–663.

DOI: https://doi.org/10.1042/BST20120345

Published: 21 March 2013

...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...

View article titled, The impact of hypoxia on cell death pathways

Articles

Apoptosis-inducing antifungal peptides and proteins

Katrijn De Brucker, Bruno P.A. Cammue, Karin Thevissen

Biochem Soc Trans (2011) 39 (5): 1527–1532.

DOI: https://doi.org/10.1042/BST0391527

Published: 21 September 2011

... are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that induce apoptosis. Their antifungal spectrum, mode of action and toxicity are discussed in more detail. Melittin, the main toxic component of the venom...

View article titled, Apoptosis-inducing antifungal peptides and proteins

Articles

Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species

Wei Zhuo, Xiaomin Song, Hao Zhou, Yongzhang Luo

Biochem Soc Trans (2011) 39 (5): 1376–1381.

DOI: https://doi.org/10.1042/BST0391376

Published: 21 September 2011

... apoptosis in endothelial cells. These findings provide a novel mechanism by which ADI inhibits tumour angiogenesis through modulating endothelial tip cells. 1 To whom correspondence should be addressed (email yluo@tsinghua.edu.cn ). 18 6 2011 © The Authors Journal compilation © 2011...

View article titled, Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species

Includes: Supplementary data

Articles

mRNA stability and control of cell proliferation

Cristina Mazzoni, Claudio Falcone

Biochem Soc Trans (2011) 39 (5): 1461–1465.

DOI: https://doi.org/10.1042/BST0391461

Published: 21 September 2011

... proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field. 1 To whom correspondence should be addressed (email Cristina.mazzoni@uniroma1.it ). 10 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis...

View article titled, mRNA stability and control of cell proliferation

Articles

Nma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae : a short survey

Birthe Fahrenkrog

Biochem Soc Trans (2011) 39 (5): 1499–1501.

DOI: https://doi.org/10.1042/BST0391499

Published: 21 September 2011

...Birthe Fahrenkrog The baker's yeast, Saccharomyces cerevisiae , is also capable of undergoing programmed cell death or apoptosis, for example in response to viral infection as well as during chronological and replicative aging. Intrinsically, programmed cell death in yeast can be induced...

View article titled, Nma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae : a short survey

Articles

Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae

Derek Wilkinson, Mark Ramsdale

Biochem Soc Trans (2011) 39 (5): 1502–1508.

DOI: https://doi.org/10.1042/BST0391502

Published: 21 September 2011

... protease 10), a deubiquitinating enzyme, yields a complex phenotype characterized by a subpopulation of cells exhibiting typical markers of apoptosis. Cells lacking Ubp10 possess endogenous caspase-like activity, which is only partially lost upon deletion of MCA1 . Loss of Mca1 suppresses the ubp10 -null...

View article titled, Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae

Articles

Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Maria João Sousa, Flávìa Azevedo, Ana Pedras, Carolina Marques, Olga P. Coutinho, Ana Preto, Hernâni Gerós, Susana R. Chaves, Manuela Côrte-Real

Biochem Soc Trans (2011) 39 (5): 1533–1537.

DOI: https://doi.org/10.1042/BST0391533

Published: 21 September 2011

...Maria João Sousa; Flávìa Azevedo; Ana Pedras; Carolina Marques; Olga P. Coutinho; Ana Preto; Hernâni Gerós; Susana R. Chaves; Manuela Côrte-Real The yeast apoptosis field emerged with the finding that key components of the apoptotic machinery are conserved in these simple eukaryotes. Thus it became...

View article titled, Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Articles

Role of oxidative stress and antioxidant enzymes in Crohn's disease

Marisa Iborra, Inés Moret, Francisco Rausell, Guillermo Bastida, Mariam Aguas, Elena Cerrillo, Pilar Nos, Belén Beltrán

Biochem Soc Trans (2011) 39 (4): 1102–1106.

DOI: https://doi.org/10.1042/BST0391102

Published: 20 July 2011

... species) can be produced under the stimulus of different cytokines such as TNFα (tumour necrosis factor α). It has been shown in different experimental models that they are also able to regulate apoptosis and other cellular processes. The status of oxidative stress elements in Crohn's disease...

View article titled, Role of oxidative stress and antioxidant enzymes in Crohn's disease

Articles

Glycosylation changes as important factors for the susceptibility to urinary tract infection

Joemar Taganna, Arjen R. de Boer, Manfred Wuhrer, Julie Bouckaert

Biochem Soc Trans (2011) 39 (1): 349–354.

DOI: https://doi.org/10.1042/BST0390349

Published: 19 January 2011

... of the infected cells. The present article focuses on possible underlying mechanisms for glycosylation changes in the uroepithelial cell receptors for FimH. Like diabetes, bacterial adhesion induces apoptosis that may bring the endoplasmic reticulum membrane with immature mannosylated glycoproteins to the surface...

View article titled, Glycosylation changes as important factors for the susceptibility to urinary tract infection

Articles

Post-transcriptional and post-translational regulation of Bcl2

Shaun Willimott, Simon D. Wagner

Biochem Soc Trans (2010) 38 (6): 1571–1575.

DOI: https://doi.org/10.1042/BST0381571

Published: 24 November 2010

... and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia. miRNA-based therapeutic approaches to treat cancer are emerging. Bcl2 is highly regulated by miRNAs and is therefore an excellent candidate for such approaches. 1 To whom correspondence should be addressed (email...

View article titled, Post-transcriptional and post-translational regulation of Bcl2

Articles

Alix and ALG-2 make a link between endosomes and neuronal death

Anne-Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, Sakina Torch, Fiona Hemming, Anne Petiot, Jean-Marc Verna, Sandrine Fraboulet, Rémy Sadoul

Biochem Soc Trans (2009) 37 (1): 200–203.

DOI: https://doi.org/10.1042/BST0370200

Published: 20 January 2009

...Anne-Laure Mahul-Mellier; Flavie Strappazzon; Christine Chatellard-Causse; Béatrice Blot; David Béal; Sakina Torch; Fiona Hemming; Anne Petiot; Jean-Marc Verna; Sandrine Fraboulet; Rémy Sadoul Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first...

View article titled, Alix and ALG-2 make a link between endosomes and neuronal death

Articles

The role of ESCRT proteins in attenuation of cell signalling

Lina M. Rodahl, Susanne Stuffers, Viola H. Lobert, Harald Stenmark

Biochem Soc Trans (2009) 37 (1): 137–142.

DOI: https://doi.org/10.1042/BST0370137

Published: 20 January 2009

.... 1 To whom correspondence should be addressed (email stenmark@ulrik.uio.no ). 17 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 apoptosis endosomal sorting complex required for transport (ESCRT) growth factor receptor Notch tumour suppressor...

View article titled, The role of ESCRT proteins in attenuation of cell signalling

Articles

Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling

Omai B. Garner, Linda G. Baum

Biochem Soc Trans (2008) 36 (6): 1472–1477.

DOI: https://doi.org/10.1042/BST0361472

Published: 19 November 2008

... physiological and cellular functions that are regulated by galectin–glycoprotein interactions. 1 To whom correspondence should be addressed (email lbaum@mednet.ucla.edu ). 10 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis endocytosis galectin...

View article titled, Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling

Articles

Life, death and burial: multifaceted impact of autophagy

Lorenzo Galluzzi, Eugenia Morselli, José Miguel Vicencio, Oliver Kepp, Nicholas Joza, Nicolas Tajeddine, Guido Kroemer

Biochem Soc Trans (2008) 36 (5): 786–790.

DOI: https://doi.org/10.1042/BST0360786

Published: 19 September 2008

... autophagic, or type II) that is characterized by the massive accumulation of autophagosomes. Regulators of apoptosis (e.g. Bcl-2 family members) also modulate autophagy, suggesting an intimate cross-talk between these two degradative pathways. It is still unclear whether autophagic vacuolization has...

View article titled, Life, death and burial: multifaceted impact of autophagy

Articles

An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells

Miriam Cnop, Mariana Igoillo-Esteve, Daniel A. Cunha, Laurence Ladrière, Décio L. Eizirik

Biochem Soc Trans (2008) 36 (5): 909–915.

DOI: https://doi.org/10.1042/BST0360909

Published: 19 September 2008

... 2008 Biochemical Society 2008 apoptosis diabetes endoplasmic reticulum stress (ER stress) insulin lipotoxicity pancreatic β-cell The ER stress response is an important adaptive cellular signalling response in cells with high secretory activity. It aims to balance secretory protein...

View article titled, An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells

Articles

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic β-cells

Noel G. Morgan, Shalinee Dhayal, Eleftheria Diakogiannaki, Hannah J. Welters

Biochem Soc Trans (2008) 36 (5): 905–908.

DOI: https://doi.org/10.1042/BST0360905

Published: 19 September 2008

...Noel G. Morgan; Shalinee Dhayal; Eleftheria Diakogiannaki; Hannah J. Welters Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence...

View article titled, The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic β-cells

Articles

Lack of TXNIP protects β-cells against glucotoxicity

Anath Shalev

Biochem Soc Trans (2008) 36 (5): 963–965.

DOI: https://doi.org/10.1042/BST0360963

Published: 19 September 2008

...Anath Shalev Glucotoxicity plays a major role in pancreatic β-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic β-cell factor that is induced by glucose...

View article titled, Lack of TXNIP protects β-cells against glucotoxicity

Articles

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic β-cell

Eleftheria Diakogiannaki, Noel G. Morgan

Biochem Soc Trans (2008) 36 (5): 959–962.

DOI: https://doi.org/10.1042/BST0360959

Published: 19 September 2008

... and in vivo Diabetes 2007 56 2927 2937 7 Butler A.E. Janson J. Bonner-Weir S. Ritzel R. Rizza R.A. Butler P.C. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes Diabetes 2003 52 102 110 8 Poitout V. Robertson R.P...

View article titled, Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic β-cell

Articles

The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

Jörg Hartkamp, Stefan G.E. Roberts

Biochem Soc Trans (2008) 36 (4): 629–631.

DOI: https://doi.org/10.1042/BST0360629

Published: 22 July 2008

... in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult...

View article titled, The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

Articles

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

Miriam Cnop

Biochem Soc Trans (2008) 36 (3): 348–352.

DOI: https://doi.org/10.1042/BST0360348

Published: 21 May 2008

... individuals. NEFAs cause β-cell apoptosis and may thus contribute to progressive β-cell loss in Type 2 diabetes. The molecular pathways and regulators involved in NEFA-mediated β-cell dysfunction and apoptosis are beginning to be understood. We have identified ER (endoplasmic reticulum) stress as one...

View article titled, Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

Articles

Insulin signalling in islets

Shanta J. Persaud, Dany Muller, Peter M. Jones

Biochem Soc Trans (2008) 36 (3): 290–293.

DOI: https://doi.org/10.1042/BST0360290

Published: 21 May 2008

... islets, and the regulatory role of insulin in protecting against β-cell apoptosis. We have identified mRNAs encoding IRs (insulin receptors) and downstream signalling elements in dissociated human islet β-cells by single-cell RT (reverse transcription)–PCR, and perifusion studies have indicated...

View article titled, Insulin signalling in islets

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