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Keywords: apoptosis
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Articles
Biochem Soc Trans (2023) BST20220807.
Published: 25 January 2023
...Xiaohui Wang; Larisa I. Labzin Programmed cell death is a critical host defence strategy during viral infection. Neighbouring cells deal with this death in distinct ways depending on how the infected cell dies. While apoptosis is considered immunologically silent, the lytic pathways of necroptosis...
Articles
Biochem Soc Trans (2023) BST20220098.
Published: 11 January 2023
... necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the development of TRAIL receptor agonists (TRAs), including...
Articles
Biochem Soc Trans (2022) 50 (6): 1583–1594.
Published: 24 November 2022
... inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis, pyroptosis to necroptosis. In this review, we first discuss the mechanisms by which RIPK1 and RIPK3 promote the assembly of death-inducing complexes and how these cell death pathways are activated as host responses...
Articles
Biochem Soc Trans (2022) 50 (5): 1517–1526.
Published: 05 October 2022
... BY) . Open access for this article was enabled by the participation of Monash University in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis Caenorhabditis elegans germ cells RNA splicing...
Articles
Biochem Soc Trans (2022) 50 (3): 1105–1118.
Published: 19 May 2022
... interactions to signal apoptosis. Fas/CD95 death receptor-mediated apoptosis requires the formation of the so-called d eath- i nducing s ignaling c omplex (DISC), bringing together Fas/CD95, Fas-associated death domain-containing protein and procaspase-8. In the last two decades, cholesterol-rich lipid raft...
Articles
Biochem Soc Trans (2022) 50 (2): 839–851.
Published: 28 March 2022
... monoclonal antibody was recently shown to increase the susceptibility of several pancreatic cancer cell lines to chemotherapeutics, increase their apoptosis, and decrease their migration. MMP-7 activities are most apparent at the surfaces of innate immune, epithelial, and tumor cells. Proteolytic shedding...
Articles
Biochem Soc Trans (2022) 50 (1): 13–20.
Published: 15 February 2022
... can contribute to autoinflammatory and autoimmune diseases or life-threatening conditions like sepsis. These diseases generally display increased levels of cell death, which, downstream of the TNF receptor, can either be caspase-dependent (apoptosis) or caspase-independent (necroptosis). Significant...
Articles
Biochem Soc Trans (2021) 49 (6): 2787–2795.
Published: 16 December 2021
...Zheng Yuan; Grant Dewson; Peter E. Czabotar; Richard W. Birkinshaw The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein–protein interactions within...
Articles
Biochem Soc Trans (2021) 49 (5): 2397–2410.
Published: 28 September 2021
...W. Douglas Fairlie; Erinna F. Lee The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro-survival members of the BCL-2 protein family to induce apoptosis in cancer cells have...
Articles
Biochem Soc Trans (2021) 49 (5): 2381–2395.
Published: 13 September 2021
... the major successes in the evolution of such ‘BH3-mimetic’ drugs. Numerous other compounds have been labelled as BH3-mimetics, including the widely studied obatoclax and gossypol. Whilst these induce apoptosis, they also affect multiple other pathways (e.g. cell cycle, autophagy, DNA damage response) [ 41...
Articles
Biochem Soc Trans (2021) 49 (2): 793–804.
Published: 12 April 2021
... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis cell clearance necroptosis necrosis phagocytosis pyroptosis For over 50 years apoptosis has dominated basic and translational research in the cell death field...
Articles
Biochem Soc Trans (2021) 49 (2): 663–674.
Published: 11 March 2021
... of intermembrane space proteins like cytochrome c , is considered a point of no return in apoptosis. MOMP is controlled by the proteins of the B-cell lymphoma 2 (BCL-2) family, including pro-and anti-apoptotic members, whose balance determines the decision between cell death and survival. Other factors...
Articles
Biochem Soc Trans (2020) 48 (5): 2079–2088.
Published: 01 September 2020
... (ApoBDs), a distinct type of EVs released by cells undergoing a form of programmed cell death called apoptosis, has been largely unexplored. Recent studies have shed light on ApoBD biogenesis and functions, promisingly implicating their therapeutic potential. In this review, we discuss many strategies...
Articles
Biochem Soc Trans (2020) 48 (2): 719–731.
Published: 08 April 2020
... different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cells, thus they can be potential sources as chemotherapeutic agents...
Articles
Biochem Soc Trans (2017) 45 (6): 1213–1223.
Published: 20 October 2017
... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis...
Articles
Biochem Soc Trans (2017) 45 (1): 123–129.
Published: 15 February 2017
...@bioacademy.gr ) 17 8 2016 11 10 2016 14 10 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis leucine-rich repeat kinase 2 neuronal death In a disease of complex etiology such as Parkinson's disease (PD...
Articles
Biochem Soc Trans (2016) 44 (5): 1531–1540.
Published: 19 October 2016
... programmed cell suicide (apoptosis). Mitochondrial intrinsic apoptotic pathways are controlled by members of pro- and anti-apoptotic Bcl-2 proteins. Bcl-2 and Bcl-xL are anti-apoptotic, whereas Bax, Bak, Bid and Bim are pro-apototic. HK-I and HK-II appear to share the same mouse VDAC1 (mVDAC1)-binding site...
Articles
Biochem Soc Trans (2015) 43 (4): 715–719.
Published: 03 August 2015
... Pt 12 3477 3486 10627045 35 Menzies B.E. Kourteva I. Internalization of Staphylococcus aureus by endothelial cells induces apoptosis Infect. Immun. 1998 66 5994 5998 9826383 36 Yao L. Bengualid V. Lowy F.D. Gibbons J.J. Hatcher V.B. Berman J.W...
Articles
Biochem Soc Trans (2015) 43 (4): 531–536.
Published: 03 August 2015
... Limited 2015 apoptosis drug design glioblastoma translocator protein Apoptosis or programmed cell death is a necessary process through which damaged cells are eliminated. Through up-regulation of anti-apoptotic proteins such as B-cell lymphoma 2 (Bcl-2), cancer cells develop...
Articles
Biochem Soc Trans (2015) 43 (4): 720–726.
Published: 03 August 2015
... ]. Activated platelets undergo apoptosis and are eliminated in the reticulo-endothelial system. CXCL11, CXCL12, MIF rescue platelets from activation and BH3 interacting-domain death agonist (BH3)-mimetic-induced apoptosis, also prolong survival of circulating platelets through CXCR7 engagement. Enhanced...
Articles
Biochem Soc Trans (2015) 43 (3): 323–327.
Published: 01 June 2015
... shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can...
Articles
Biochem Soc Trans (2015) 43 (2): 297–301.
Published: 07 April 2015
...). The recruitment of autophagic proteins at ER-mitochondria contacts for the subsequent formation of autophagosomes was also documented in mammalian cells, following starvation [ 20 ]. Last, but not least, previous literature suggests a direct involvement of ER-mitochondria bridging in the induction of apoptosis...
Articles
Biochem Soc Trans (2015) 43 (2): 229–234.
Published: 07 April 2015
... cleavage. It promotes membrane binding and relocalization of functional protein domains released by caspase cleavage during apoptosis, or programmed cell death. However, as the requirement of caspase cleavage has expanded beyond just cell death, it has become apparent that PTMyr may play a role in cell...
Articles
Biochem Soc Trans (2014) 42 (6): 1519–1523.
Published: 17 November 2014
... is to pinpoint the underlying key factors and to develop therapies for their direct targeting. Protein kinase C (PKC) enzymes are promising candidates, as some PKCs were shown to be involved in regulation of apoptosis. Our studies and others have shown that PKCη is an anti-apoptotic kinase, able to confer...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
...Margaret M. Briehl; Margaret E. Tome; Sarah T. Wilkinson; Melba C. Jaramillo; Kristy Lee Characteristics of cancer cells include a more oxidized redox environment, metabolic reprogramming and apoptosis resistance. Our studies with a lymphoma model have explored connections between the cellular...
Articles
Biochem Soc Trans (2014) 42 (1): 125–129.
Published: 23 January 2014
... to treat ovarian cancer. 1 These authors contributed equally to this article. 2 To whom correspondence should be addressed (email a.richardson1@keele.ac.uk ). 28 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 apoptosis autotaxin BH3 mimetic...
Articles
Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
...Julea N. Butt Apoptosis is triggered by an accumulation of ROS (reactive oxygen species) produced by proteins of the mitochondrial respiratory chain. The levels of ROS are controlled by the activities of mitochondrial redox proteins such as glutaredoxin 2 that help to modulate the susceptibility...
Articles
Biochem Soc Trans (2013) 41 (2): 657–663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Articles
Biochem Soc Trans (2011) 39 (5): 1527–1532.
Published: 21 September 2011
... are antimicrobial peptides. In the present review, we provide an overview of antifungal peptides isolated from plants, insects, amphibians and mammals that induce apoptosis. Their antifungal spectrum, mode of action and toxicity are discussed in more detail. 1 To whom correspondence should be addressed...
Articles
Biochem Soc Trans (2011) 39 (5): 1376–1381.
Published: 21 September 2011
... apoptosis in endothelial cells. These findings provide a novel mechanism by which ADI inhibits tumour angiogenesis through modulating endothelial tip cells. 1 To whom correspondence should be addressed (email yluo@tsinghua.edu.cn ). 18 6 2011 © The Authors Journal compilation © 2011...
Includes: Supplementary data
Articles
Biochem Soc Trans (2011) 39 (5): 1461–1465.
Published: 21 September 2011
... proliferation, virus replication and cell death. In this paper, we will review the newest findings in this field. 1 To whom correspondence should be addressed (email Cristina.mazzoni@uniroma1.it ). 10 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis...
Articles
Biochem Soc Trans (2011) 39 (5): 1499–1501.
Published: 21 September 2011
...Birthe Fahrenkrog The baker's yeast, Saccharomyces cerevisiae , is also capable of undergoing programmed cell death or apoptosis, for example in response to viral infection as well as during chronological and replicative aging. Intrinsically, programmed cell death in yeast can be induced...
Articles
Biochem Soc Trans (2011) 39 (5): 1502–1508.
Published: 21 September 2011
...@exeter.ac.uk ). 17 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis caspase necrosis programmed cell death (PCD) protease Saccharomyces cerevisiae Understanding the molecular mechanisms regulating and executing PCD (programmed cell death...
Articles
Biochem Soc Trans (2011) 39 (5): 1533–1537.
Published: 21 September 2011
...Maria João Sousa; Flávìa Azevedo; Ana Pedras; Carolina Marques; Olga P. Coutinho; Ana Preto; Hernâni Gerós; Susana R. Chaves; Manuela Côrte-Real The yeast apoptosis field emerged with the finding that key components of the apoptotic machinery are conserved in these simple eukaryotes. Thus it became...
Articles
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
... species) can be produced under the stimulus of different cytokines such as TNFα (tumour necrosis factor α). It has been shown in different experimental models that they are also able to regulate apoptosis and other cellular processes. The status of oxidative stress elements in Crohn's disease...
Articles
Biochem Soc Trans (2011) 39 (1): 349–354.
Published: 19 January 2011
... of the infected cells. The present article focuses on possible underlying mechanisms for glycosylation changes in the uroepithelial cell receptors for FimH. Like diabetes, bacterial adhesion induces apoptosis that may bring the endoplasmic reticulum membrane with immature mannosylated glycoproteins to the surface...
Articles
Biochem Soc Trans (2010) 38 (6): 1571–1575.
Published: 24 November 2010
... and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia. miRNA-based therapeutic approaches to treat cancer are emerging. Bcl2 is highly regulated by miRNAs and is therefore an excellent candidate for such approaches. Bcl2 and its related family members play a central role...
Articles
Biochem Soc Trans (2009) 37 (1): 200–203.
Published: 20 January 2009
...Anne-Laure Mahul-Mellier; Flavie Strappazzon; Christine Chatellard-Causse; Béatrice Blot; David Béal; Sakina Torch; Fiona Hemming; Anne Petiot; Jean-Marc Verna; Sandrine Fraboulet; Rémy Sadoul Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first...
Articles
Biochem Soc Trans (2009) 37 (1): 137–142.
Published: 20 January 2009
.... 1 To whom correspondence should be addressed (email stenmark@ulrik.uio.no ). 17 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 apoptosis endosomal sorting complex required for transport (ESCRT) growth factor receptor Notch tumour suppressor...
Articles
Biochem Soc Trans (2008) 36 (6): 1472–1477.
Published: 19 November 2008
... physiological and cellular functions that are regulated by galectin–glycoprotein interactions. 1 To whom correspondence should be addressed (email lbaum@mednet.ucla.edu ). 10 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis endocytosis galectin...
Articles
Biochem Soc Trans (2008) 36 (5): 959–962.
Published: 19 September 2008
...@pms.ac.uk ). 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis eukaryotic initiation factor 2α (eIF2α) integrated stress response palmitate palmitoleate pancreatic β-cell The molecular mechanisms involved in mediating the pro-apoptotic...
Articles
Biochem Soc Trans (2008) 36 (5): 905–908.
Published: 19 September 2008
...Noel G. Morgan; Shalinee Dhayal; Eleftheria Diakogiannaki; Hannah J. Welters Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory function and enhanced apoptosis by a process of ‘lipotoxicity’, which may be a contributory factor to the rising incidence...
Articles
Biochem Soc Trans (2008) 36 (5): 963–965.
Published: 19 September 2008
...Anath Shalev Glucotoxicity plays a major role in pancreatic β-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic β-cell factor that is induced by glucose...
Articles
Biochem Soc Trans (2008) 36 (5): 909–915.
Published: 19 September 2008
... analysis in INS-1E cells exposed to the reversible SERCA blocker CPA for up to 12 h, including an additional group of cells treated for 6 h and then allowed to recover without CPA for 3 h [ 40 ]. CPA, shown previously to induce severe β-cell ER stress and apoptosis [ 30 , 41 ], modified expression...
Articles
Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... autophagic, or type II) that is characterized by the massive accumulation of autophagosomes. Regulators of apoptosis (e.g. Bcl-2 family members) also modulate autophagy, suggesting an intimate cross-talk between these two degradative pathways. It is still unclear whether autophagic vacuolization has...
Articles
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
... in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult...
Articles
Biochem Soc Trans (2008) 36 (3): 348–352.
Published: 21 May 2008
... individuals. NEFAs cause β-cell apoptosis and may thus contribute to progressive β-cell loss in Type 2 diabetes. The molecular pathways and regulators involved in NEFA-mediated β-cell dysfunction and apoptosis are beginning to be understood. We have identified ER (endoplasmic reticulum) stress as one...
Articles
Biochem Soc Trans (2008) 36 (3): 290–293.
Published: 21 May 2008
... islets, and the regulatory role of insulin in protecting against β-cell apoptosis. We have identified mRNAs encoding IRs (insulin receptors) and downstream signalling elements in dissociated human islet β-cells by single-cell RT (reverse transcription)–PCR, and perifusion studies have indicated...
Articles
Biochem Soc Trans (2008) 36 (3): 321–327.
Published: 21 May 2008
...Decio L. Eizirik; Fabrice Moore; Daisy Flamez; Fernanda Ortis Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that β-cell apoptosis depends on the parallel...
Articles
Biochem Soc Trans (2008) 36 (3): 334–339.
Published: 21 May 2008
... and TNFα mediate activation of the transcription factor NF-κB (nuclear factor κB) pathway. Use of a degradation-resistant NF-κB protein inhibitor (ΔNIκBα), specifically expressed in β-cells, significantly reduced IL-1β+IFN-γ-induced apoptosis. Moreover, in vivo , it protected against multiple low-dose...