... at transcriptional and translational levels and by regulation of its degradation. Here we review the mechanism of ODC degradation with particular emphasis on AzI (antizyme inhibitor), an ODC homologous protein that appears as a central regulator of ODC stability, cellular polyamine homoeostasis and cellular...

.... Accordingly, effective cellular levels of polyamine analogues are generally inversely related to their capacity to induce antizyme. Antizyme activity is down-regulated by interaction with several binding partners, most notably antizyme inhibitor, and at least a few tumour tissues exhibit deficiencies...

... The Biochemical Society 2007 antizyme antizyme inhibitor ornithine decarboxylase (ODC) putrescine spermidine spermidine/spermine- N 1 -acetyltransferase (SSAT) The only proven route in mammals for the de novo formation of putrescine is via the activity of ODC ( L -ornithine decarboxylase...