... at transcriptional and translational levels and by regulation of its degradation. Here we review the mechanism of ODC degradation with particular emphasis on AzI (antizyme inhibitor), an ODC homologous protein that appears as a central regulator of ODC stability, cellular polyamine homoeostasis and cellular...

... incorporated to these levels, many of these analogues induce the synthesis of a regulatory protein, antizyme, which inhibits both polyamine synthesis and the transporter they used to enter the cell. Thus this feedback system allows steady-state maintenance of effective cellular doses of such analogues...

... of studies using transgenic mice in which the levels of proteins that regulate these processes ( L -ornithine decarboxylase, antizyme and spermidine/spermine- N 1 -acetyltransferase) are altered. 1 To whom correspondence should be addressed (email aep1@psu.edu ). 12 10 2006 © 2007...

... in biological behaviour of prostatic (cancer) cells are associated with changes in polyamine levels and/or the activity of their metabolic enzymes. Faulty antizyme regulation of polyamine homoeostasis may play an important role in the growth and progression of prostatic carcinoma. Treatment of human prostate...

... Biochemical Society 2003 acetyltransferase antizyme decarboxylase putrescine spermidine spermine Abbreviations used: ODC; ornithine decarboxylase; AdoMetDC, S-adenosylmethionine decarboxylase; SSAT, spermidine/spermine-N 1 -acetyltransferase; PAO, polyamine oxidase; AZ, antizyme; ES...