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Biochem Soc Trans (2022) 50 (5): 1315–1328.
Published: 05 October 2022
...-ND) . antibiotics biosynthesis drug discovery and design metabolic engineering Antimicrobial-resistant (AMR) infections pose a serious threat to society [ 1 ], driving the need to discover and develop new antimicrobial molecules. Promising sources of such antimicrobials are naturally...
Biochem Soc Trans (2022) 50 (5): 1269–1279.
Published: 12 September 2022
...Callaghan Cylke; Fangwei Si; Shiladitya Banerjee Characterizing the physiological response of bacterial cells to antibiotic treatment is crucial for the design of antibacterial therapies and for understanding the mechanisms of antibiotic resistance. While the effects of antibiotics are commonly...
Biochem Soc Trans (2020) 48 (5): 2139–2149.
Published: 02 October 2020
... of antibiotic resistance has catalysed a renewed interest in understanding the mechanisms underlying the dynamics of antibiotics interaction with the bacterial cell envelope. It is widely recognised that the key reason behind the remarkable success of Gram-negative pathogens in developing antibiotic resistance...
Biochem Soc Trans (2020) 48 (5): 2029–2037.
Published: 11 September 2020
...J. Shaun Lott Mycobacterium tuberculosis , the causative agent of tuberculosis (TB), is the most significant cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M. tuberculosis represent a threat to effective treatment, and the long duration, toxicity...
Biochem Soc Trans (2019) 47 (1): 477–486.
Published: 19 February 2019
...Ciara Tyrrell; Catherine M. Burgess; Fiona P. Brennan; Fiona Walsh Antibiotic resistance is currently one of the greatest threats to human health. The global overuse of antibiotics in human medicine and in agriculture has resulted in the proliferation and dissemination of a multitude of antibiotic...
Biochem Soc Trans (2019) 47 (1): 339–350.
Published: 15 January 2019
...Hamed Mosaei; John Harbottle Transcription, the first phase of gene expression, is performed by the multi-subunit RNA polymerase (RNAP). Bacterial RNAP is a validated target for clinical antibiotics. Many natural and synthetic compounds are now known to target RNAP, inhibiting various stages...
Biochem Soc Trans (2018) 46 (6): 1505–1515.
Published: 31 October 2018
... the GAG-binding ability of the two known isoforms [ 67 ]. Correspondence: Andreas J. Kungl ( firstname.lastname@example.org ) 5 3 2018 6 9 2018 18 9 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antibiotics...