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Keywords: ankyrin repeat
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Articles

The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder

Angela Bertagna, Dima Toptygin, Ludwig Brand, Doug Barrick
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (2): 157–166.
https://doi.org/10.1042/BST0360157
Published: 20 March 2008
... and ANK (ankyrin repeat)-binding regions using polymer statistics. A WLC (wormlike chain) model shows that the most probable sequence separation between the two binding regions is ∼50 Å (1 Å=0.1 nm), matching the separation between these two sites in the complex. The WLC model predicts a substantial...
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Articles

Assembly domains in TRP channels

R. Schindl, C. Romanin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 84–85.
https://doi.org/10.1042/BST0350084
Published: 22 January 2007
... ankyrin repeat assembly domain coiled-coil domain tetramer transient receptor potential channel (TRP channel) transmembrane domain A tetrameric structure has been demonstrated by cross-linking analysis or blue native PAGE, for the TRPV1 (TRP vanilloid 1) channel [ 1 , 2 ], and via concatamers...
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Articles

The TRP channel superfamily: insights into how structure, protein–lipid interactions and localization influence function

B.J. Reaves, A.J. Wolstenholme
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 77–80.
https://doi.org/10.1042/BST0350077
Published: 22 January 2007
... interests, including biochemistry, cell biology, physiology and neuroscience, and inspired lively discussion on the issues reviewed herein. adenosine diphosphoribose (ADPR) ankyrin repeat channel assembly coiled-coil domain phosphatidylinositol bisphosphate (PIP 2 ) transient receptor potential (TRP...
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