Page 1 | Search Results | Biochemical Society Transactions

1-50 of 57

Sort by

Sort Order Select

Articles

Extracellular matrix: the gatekeeper of tumor angiogenesis

Maurizio Mongiat, Simone Buraschi, Eva Andreuzzi, Thomas Neill, Renato V. Iozzo

Biochem Soc Trans (2019) 47 (5): 1543–1555.

https://doi.org/10.1042/BST20190653

Published: 11 October 2019

... matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action. angiogenesis cancer biology matrix biology proteoglycans signaling tumor microenvironments Correspondence: Maurizo Mongiat ( mmongiat@cro.it...

View article titled, Extracellular matrix: the gatekeeper of tumor angiogenesis

Articles

The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall

Lilian Schimmel, Emma Gordon

Biochem Soc Trans (2018) 46 (6): 1673–1680.

https://doi.org/10.1042/BST20180377

Published: 04 December 2018

..., such as vasculogenesis, angiogenesis, vascular leakage and leukocyte extravasation. Endothelial cell adhesion is a critical factor in the establishment of the primitive vascular plexus. During early vasculogenesis in the mouse, endothelial cell precursors arise at embryonic day 8 and subsequently assemble...

View article titled, The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall

Articles

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function

Amaya García de Vinuesa, Matteo Bocci, Kristian Pietras, Peter ten Dijke

Biochem Soc Trans (2016) 44 (4): 1142–1149.

https://doi.org/10.1042/BST20160093

Published: 15 August 2016

...Amaya García de Vinuesa; Matteo Bocci; Kristian Pietras; Peter ten Dijke Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway...

View article titled, Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function

Articles

miRNAs in post-ischaemic angiogenesis and vascular remodelling

Jaimy Saif, Costanza Emanueli

Biochem Soc Trans (2014) 42 (6): 1629–1636.

https://doi.org/10.1042/BST20140263

Published: 17 November 2014

...Jaimy Saif; Costanza Emanueli miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review...

View article titled, miRNAs in post-ischaemic angiogenesis and vascular remodelling

Articles

Mechanisms that influence tumour response to VEGF-pathway inhibitors

Neil R. Smith, Stephen R. Wedge, Aurelien Pommier, Simon T. Barry

Biochem Soc Trans (2014) 42 (6): 1601–1607.

https://doi.org/10.1042/BST20140261

Published: 17 November 2014

...Neil R. Smith; Stephen R. Wedge; Aurelien Pommier; Simon T. Barry There has been significant investment in developing novel therapies to target solid tumour vasculature. Different technical approaches have been utilized with the aim of inhibiting tumour angiogenesis or compromising the function...

View article titled, Mechanisms that influence tumour response to VEGF-pathway inhibitors

Articles

Exploring the role of endothelium in the tumour response to anti-angiogenic therapy

Yi-Chao He, Michael M. Halford, Marc G. Achen, Steven A. Stacker

Biochem Soc Trans (2014) 42 (6): 1569–1575.

https://doi.org/10.1042/BST20140173

Published: 17 November 2014

... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) Bevacizumab (Avastin®; Genentech/Roche) is a humanized monoclonal antibody that neutralizes all isoforms of VEGF-A with high specificity, thereby...

View article titled, Exploring the role of endothelium in the tumour response to anti-angiogenic therapy

Articles

Syndecans in angiogenesis and endothelial cell biology

Giulia De Rossi, James R. Whiteford

Biochem Soc Trans (2014) 42 (6): 1643–1646.

https://doi.org/10.1042/BST20140232

Published: 17 November 2014

... development; however, under conditions of challenge or insult, several phenotypes have emerged. Angiogenesis is an important process both in development and in wound healing, but also in pathologies such as cancer and chronic inflammatory conditions. In the present paper, we summarize the main studies...

View article titled, Syndecans in angiogenesis and endothelial cell biology

Articles

Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway

Colin E. Murdoch, Markus M. Bachschmid, Reiko Matsui

Biochem Soc Trans (2014) 42 (6): 1665–1670.

https://doi.org/10.1042/BST20140213

Published: 17 November 2014

... stimulated the Wnt5a/sFlt-1 pathway through enhancing NF-κB signalling. These studies show a novel role for Glrx in post-ischaemic neovascularization, which could define a potential target for therapy of impaired angiogenesis in pathological conditions including diabetes. 1 To whom correspondence...

View article titled, Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway

Articles

The emerging quest for the optimal angiostatic combination therapy

Arjan W. Griffioen, Andrea Weiss, Robert H. Berndsen, U. Kulsoom Abdul, Marije T. te Winkel, Patrycja Nowak-Sliwinska

Biochem Soc Trans (2014) 42 (6): 1608–1615.

https://doi.org/10.1042/BST20140193

Published: 17 November 2014

... angiogenesis inhibitors can only arise from two efforts. First, through the identification of better targets, preferably specifically expressed in the tumour vasculature. Secondly, through the development of combination therapies. The present review highlights the current efforts and challenges in trying...

View article titled, The emerging quest for the optimal angiostatic combination therapy

Articles

The role of ERK5 in endothelial cell function

Gopika N. Nithianandarajah-Jones, Bettina Wilm, Christopher E.P. Goldring, Jürgen Müller, Michael J. Cross

Biochem Soc Trans (2014) 42 (6): 1584–1589.

https://doi.org/10.1042/BST20140276

Published: 17 November 2014

... cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...

View article titled, The role of ERK5 in endothelial cell function

Articles

Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis

Samuel J. Atkinson, Tim S. Ellison, Veronica Steri, Emma Gould, Stephen D. Robinson

Biochem Soc Trans (2014) 42 (6): 1590–1595.

https://doi.org/10.1042/BST20140206

Published: 17 November 2014

... the years, studies in β3-integrin-knockout mice have shed some light on possible explanations for disappointing clinical outcomes. However, studying angiogenesis in β3-integrin-knockout mice is a blunt tool to investigate β3-integrin's role in pathological angiogenesis. Since establishing our laboratory...

View article titled, Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis

Articles

Notch functions in developmental and tumour angiogenesis by diverse mechanisms 1

Thaned Kangsamaksin, Ian W. Tattersall, Jan Kitajewski

Biochem Soc Trans (2014) 42 (6): 1563–1568.

https://doi.org/10.1042/BST20140233

Published: 17 November 2014

...Thaned Kangsamaksin; Ian W. Tattersall; Jan Kitajewski The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis. Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting, demonstrating that Notch regulates tip-stalk cell identity...

View article titled, Notch functions in developmental and tumour angiogenesis by diverse mechanisms 1

Articles

Neuropilin regulation of angiogenesis

Anastasia Lampropoulou, Christiana Ruhrberg

Biochem Soc Trans (2014) 42 (6): 1623–1628.

https://doi.org/10.1042/BST20140244

Published: 17 November 2014

...Anastasia Lampropoulou; Christiana Ruhrberg Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia...

View article titled, Neuropilin regulation of angiogenesis

Articles

The development of anti-angiogenic heparan sulfate oligosaccharides

Gordon C. Jayson, Gavin J. Miller, Steen U. Hansen, Marek Barath, John M. Gardiner, Egle Avizienyte

Biochem Soc Trans (2014) 42 (6): 1596–1600.

https://doi.org/10.1042/BST20140229

Published: 17 November 2014

...Gordon C. Jayson; Gavin J. Miller; Steen U. Hansen; Marek Barath; John M. Gardiner; Egle Avizienyte Angiogenesis has emerged as a novel target for anti-cancer therapies through randomized clinical trials that tested the benefit of adding vascular endothelial growth factor (VEGF) inhibitors...

View article titled, The development of anti-angiogenic heparan sulfate oligosaccharides

Articles

A review of ELTD1, a pro-angiogenic adhesion GPCR

David M. Favara, Alison H. Banham, Adrian L. Harris

Biochem Soc Trans (2014) 42 (6): 1658–1664.

https://doi.org/10.1042/BST20140216

Published: 17 November 2014

... regulator of angiogenesis. In this mini-review, we present an overview of the current literature on ELTD1 and present bioinformatics data showing ELTD1's sequence conservation, its expression in cancer cell lines and its mutational frequency in human cancers. Additionally, we present sequence homology...

View article titled, A review of ELTD1, a pro-angiogenic adhesion GPCR

Articles

New insight into the intracellular roles of class II phosphoinositide 3-kinases

Tania Maffucci, Marco Falasca

Biochem Soc Trans (2014) 42 (5): 1378–1382.

https://doi.org/10.1042/BST20140140

Published: 18 September 2014

... regulates specific cellular functions and it is not redundant with other isoforms. 1 To whom correspondence should be addressed (email t.maffucci@qmul.ac.uk ) . 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis cilium endothelial cell...

View article titled, New insight into the intracellular roles of class II phosphoinositide 3-kinases

Articles

Neuropilin-1 enforces extracellular matrix signalling via ABL1 to promote angiogenesis

Claudio Raimondi

Biochem Soc Trans (2014) 42 (5): 1429–1434.

https://doi.org/10.1042/BST20140141

Published: 18 September 2014

... expression die embryonically and show severe neuronal and cardiovascular defects. Even though the contribution of NRP1 to vascular development has been mainly ascribed to its function as a VEGF-A receptor, recent evidence suggests that NRP1 contributes to angiogenesis through VEGF-independent mechanisms...

View article titled, Neuropilin-1 enforces extracellular matrix signalling via ABL1 to promote angiogenesis

Articles

Regenerative effects of adipose-tissue-derived stem cells for treatment of peripheral nerve injuries

Mallappa K. Kolar, Paul J. Kingham

Biochem Soc Trans (2014) 42 (3): 697–701.

https://doi.org/10.1042/BST20140004

Published: 22 May 2014

... transition zone NGF, NT-3, GDNF, bFGF Survival Motor neuron survival BDNF, NT-3, NT-4/5, CNTF, GDNF, IGF-1 Sensory neuron survival NGF, NT-4/5, GDNF 7 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 adipose-tissue-derived stem cell angiogenesis...

View article titled, Regenerative effects of adipose-tissue-derived stem cells for treatment of peripheral nerve injuries

Articles

Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment

Katrin J. Svensson, Mattias Belting

Biochem Soc Trans (2013) 41 (1): 273–276.

https://doi.org/10.1042/BST20120248

Published: 29 January 2013

... on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis. 1 To whom correspondence should be addressed (email Mattias.Belting@med.lu.se...

View article titled, Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment

Articles

Neuropilin signalling in angiogenesis

Sina Koch

Biochem Soc Trans (2012) 40 (1): 20–25.

https://doi.org/10.1042/BST20110689

Published: 19 January 2012

... such as NRPs (neuropilins) associate with the ligand–receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue...

View article titled, Neuropilin signalling in angiogenesis

Articles

ERK5 and its role in tumour development

Pamela A. Lochhead, Rebecca Gilley, Simon J. Cook

Biochem Soc Trans (2012) 40 (1): 251–256.

https://doi.org/10.1042/BST20110663

Published: 19 January 2012

... with recognized cell survival kinases such as PKB (protein kinase B) and ERK1/2. Tumours require a blood supply to deliver nutrients and oxygen and to remove metabolic waste and carbon dioxide. Angiogenesis is the sprouting of new blood vessels from existing ones and, in tumour progression...

View article titled, ERK5 and its role in tumour development

Articles

Angiogenic properties of the chemokine RANTES/CCL5

Nadine Suffee, Benjamin Richard, Hanna Hlawaty, Olivier Oudar, Nathalie Charnaux, Angela Sutton

Biochem Soc Trans (2011) 39 (6): 1649–1653.

https://doi.org/10.1042/BST20110651

Published: 21 November 2011

... in the destabilization of this plaque. Cellular and molecular approaches are studied by in vitro assay of activated endothelial cells and in in vivo models of neovascularization. Chemokines are a large family of small secreted proteins that have been shown to play a critical role in the regulation of angiogenesis during...

View article titled, Angiogenic properties of the chemokine RANTES/CCL5

Articles

The role of RhoJ in endothelial cell biology and angiogenesis

Katarzyna Leszczynska, Sukhbir Kaur, Eleanor Wilson, Roy Bicknell, Victoria L. Heath

Biochem Soc Trans (2011) 39 (6): 1606–1611.

https://doi.org/10.1042/BST20110702

Published: 21 November 2011

... reports of its role in endothelial cells and angiogenesis. 1 To whom correspondence should be addressed (email v.heath@bham.ac.uk ). 10 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actomyosin contractility angiogenesis endothelium focal adhesion...

View article titled, The role of RhoJ in endothelial cell biology and angiogenesis

Articles

Shear stress, tip cells and regulators of endothelial migration

Xiaodong Zhuang, Darren Cross, Victoria L. Heath, Roy Bicknell

Biochem Soc Trans (2011) 39 (6): 1571–1575.

https://doi.org/10.1042/BST20110746

Published: 21 November 2011

... correspondence should be addressed (email r.bicknell@bham.ac.uk ). 23 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis C-type lectin 14A (CLEC14A) endothelial cell-specific chemotaxis regulator (ECSCR) roundabout 4 (Robo4) Angiogenesis...

View article titled, Shear stress, tip cells and regulators of endothelial migration

Articles

New pathways and mechanisms regulating and responding to Delta-like ligand 4–Notch signalling in tumour angiogenesis

Chern Ein Oon, Adrian L. Harris

Biochem Soc Trans (2011) 39 (6): 1612–1618.

https://doi.org/10.1042/BST20110721

Published: 21 November 2011

...Chern Ein Oon; Adrian L. Harris Notch signalling is a key pathway controlling angiogenesis in normal tissues and tumours. This has become a major focus of development of anticancer therapy, but to develop this appropriately, we need further understanding of the mechanisms of regulation of Dll4...

View article titled, New pathways and mechanisms regulating and responding to Delta-like ligand 4–Notch signalling in tumour angiogenesis

Articles

Vascular remodelling in human skeletal muscle

Thomas Gustafsson

Biochem Soc Trans (2011) 39 (6): 1628–1632.

https://doi.org/10.1042/BST20110720

Published: 21 November 2011

...Thomas Gustafsson Exercise-induced angiogenesis in skeletal muscle involves both non-sprouting and sprouting angiogenesis and results from the integrated responses of multiple systems and stimuli. VEGF-A (vascular endothelial growth factor A) levels are increased in exercised muscle and have been...

View article titled, Vascular remodelling in human skeletal muscle

Articles

Uses of the in vitro endothelial–fibroblast organotypic co-culture assay in angiogenesis research

Clare Hetheridge, Georgia Mavria, Harry Mellor

Biochem Soc Trans (2011) 39 (6): 1597–1600.

https://doi.org/10.1042/BST20110738

Published: 21 November 2011

...Clare Hetheridge; Georgia Mavria; Harry Mellor Angiogenesis is a complex process that involves multiple cellular events. In addition to receiving inputs from a range of stimulatory and inhibitory factors, endothelial cells undergoing angiogenesis make multiple interactions with the extracellular...

View article titled, Uses of the in vitro endothelial–fibroblast organotypic co-culture assay in angiogenesis research

Articles

Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease

Marwa Mahmoud, Paul D. Upton, Helen M. Arthur

Biochem Soc Trans (2011) 39 (6): 1659–1666.

https://doi.org/10.1042/BST20110664

Published: 21 November 2011

... the ENG (endoglin) or the ACVRL1 (activin receptor-like kinase 1) gene. Both genes are essential for angiogenesis during development and mice that are homozygous for mutations in Eng or Acvrl1 die in mid-gestation from vascular defects. Recent development of conditional mouse models in which the Eng...

View article titled, Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease

Articles

PPARs and angiogenesis

David Bishop-Bailey

Biochem Soc Trans (2011) 39 (6): 1601–1605.

https://doi.org/10.1042/BST20110643

Published: 21 November 2011

..., but were also found to be expressed in endothelial cells in the late 1990s. The early endothelial focus of PPARs was PPARγ, the molecular target for the insulin-sensitizing thiazolidinedione/glitazone class of drugs. Activation of PPARγ was shown to inhibit angiogenesis in vitro and in models...

View article titled, PPARs and angiogenesis

Articles

Inhibition of angiogenesis and the angiogenesis/invasion shift

Andreas Bikfalvi, Michel Moenner, Sophie Javerzat, Sophie North, Martin Hagedorn

Biochem Soc Trans (2011) 39 (6): 1560–1564.

https://doi.org/10.1042/BST20110710

Published: 21 November 2011

...Andreas Bikfalvi; Michel Moenner; Sophie Javerzat; Sophie North; Martin Hagedorn Angiogenesis has become a major target in cancer therapy. However, current therapeutic strategies have their limitations and raise several problems. In most tumours, anti-angiogenesis treatment targeting VEGF (vascular...

View article titled, Inhibition of angiogenesis and the angiogenesis/invasion shift

Articles

Class 3 semaphorins and their receptors in physiological and pathological angiogenesis

Carolyn A. Staton

Biochem Soc Trans (2011) 39 (6): 1565–1570.

https://doi.org/10.1042/BST20110654

Published: 21 November 2011

... functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis. 1...

View article titled, Class 3 semaphorins and their receptors in physiological and pathological angiogenesis

Articles

Advances in the Cellular and Molecular Biology of Angiogenesis

Stuart Egginton, Roy Bicknell

Biochem Soc Trans (2011) 39 (6): 1551–1555.

https://doi.org/10.1042/BST20110749

Published: 21 November 2011

...Stuart Egginton; Roy Bicknell Capillaries have been recognized for over a century as one of the most important components in regulating tissue oxygen transport, and their formation or angiogenesis a pivotal element of tissue remodelling during development and adaptation. Clinical interest stems...

View article titled, Advances in the Cellular and Molecular Biology of Angiogenesis

Articles

How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns

Ian C. Zachary

Biochem Soc Trans (2011) 39 (6): 1583–1591.

https://doi.org/10.1042/BST20110697

Published: 21 November 2011

... to wild-type NRP1, and also blocked VEGF-dependent complex formation between NRP1 and VEGFR2 and reduced VEGF-stimulated EC migration. Y297A NRP1 also partially inhibited VEGF stimulation of branching endothelial tubule formation in an organotypic co-culture model of angiogenesis [ 13 ]. These findings...

View article titled, How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns

Articles

Molecular control of angiopoietin signalling

Harprit Singh, Tariq A. Tahir, Deborah O.A. Alawo, Eyad Issa, Nicholas P.J. Brindle

Biochem Soc Trans (2011) 39 (6): 1592–1596.

https://doi.org/10.1042/BST20110699

Published: 21 November 2011

...Harprit Singh; Tariq A. Tahir; Deborah O.A. Alawo; Eyad Issa; Nicholas P.J. Brindle The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1...

View article titled, Molecular control of angiopoietin signalling

Articles

Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species

Wei Zhuo, Xiaomin Song, Hao Zhou, Yongzhang Luo

Biochem Soc Trans (2011) 39 (5): 1376–1381.

https://doi.org/10.1042/BST0391376

Published: 21 September 2011

...Wei Zhuo; Xiaomin Song; Hao Zhou; Yongzhang Luo ADI (arginine deiminase), an enzyme that hydrolyses arginine, has been reported as an anti-angiogenesis agent. However, its molecular mechanism is unclear. We have demonstrated for the first time that ADI modulates the angiogenic activity...

View article titled, Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species

Includes: Supplementary data

Articles

Inflammation: a role for NR4A orphan nuclear receptors?

Jason P. McMorrow, Evelyn P. Murphy

Biochem Soc Trans (2011) 39 (2): 688–693.

https://doi.org/10.1042/BST0390688

Published: 22 March 2011

... evelyn.murphy@ucd.ie ). 29 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 acute inflammation angiogenesis chronic inflammation cytokine macrophage polarization nuclear receptor Chronic inflammation and hyperplasia of the synovium are hallmarks of both...

View article titled, Inflammation: a role for NR4A orphan nuclear receptors?

Articles

The role of neuropilins in cell signalling

Ian C. Zachary, Paul Frankel, Ian M. Evans, Caroline Pellet-Many

Biochem Soc Trans (2009) 37 (6): 1171–1178.

https://doi.org/10.1042/BST0371171

Published: 19 November 2009

... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...

View article titled, The role of neuropilins in cell signalling

Articles

ERK5 and the regulation of endothelial cell function

Owain Llŷr Roberts, Katherine Holmes, Jürgen Müller, Darren A.E. Cross, Michael J. Cross

Biochem Soc Trans (2009) 37 (6): 1254–1259.

https://doi.org/10.1042/BST0371254

Published: 19 November 2009

... is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...

View article titled, ERK5 and the regulation of endothelial cell function

Articles

Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells

Caroline P.D. Wheeler-Jones, Charlotte Farrar, Elena Garonna

Biochem Soc Trans (2009) 37 (6): 1179–1183.

https://doi.org/10.1042/BST0371179

Published: 19 November 2009

...Caroline P.D. Wheeler-Jones; Charlotte Farrar; Elena Garonna COX (cyclo-oxygenase)-2 and members of the PAR (protease-activated receptor) family (PARs 1–4) are highly overexpressed in a number of angiogenesis-dependent pathologies, including advanced atherosclerosis and cancer. An appreciation...

View article titled, Protease-activated receptors, cyclo-oxygenases and pro-angiogenic signalling in endothelial cells

Articles

VEGFRs and Notch: a dynamic collaboration in vascular patterning

Lars Jakobsson, Katie Bentley, Holger Gerhardt

Biochem Soc Trans (2009) 37 (6): 1233–1236.

https://doi.org/10.1042/BST0371233

Published: 19 November 2009

..., controlling arterial cell specification and tip versus stalk cell selection. During sprouting angiogenesis, tip cell formation is the default response to VEGF (vascular endothelial growth factor), whereas the stalk cell phenotype is acquired through Dll4/Notch-mediated lateral inhibition. Precisely how Notch...

View article titled, VEGFRs and Notch: a dynamic collaboration in vascular patterning

Articles

VEGF receptor trafficking in angiogenesis

Alice Scott, Harry Mellor

Biochem Soc Trans (2009) 37 (6): 1184–1188.

https://doi.org/10.1042/BST0371184

Published: 19 November 2009

... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...

View article titled, VEGF receptor trafficking in angiogenesis

Articles

The anti-angiogenic isoforms of VEGF in health and disease

Yan Qiu, Coralie Hoareau-Aveilla, Sebastian Oltean, Steven J. Harper, David O. Bates

Biochem Soc Trans (2009) 37 (6): 1207–1213.

https://doi.org/10.1042/BST0371207

Published: 19 November 2009

... associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys–Drash syndrome and pre-eclampsia). Administration of recombinant VEGF 165 b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma...

View article titled, The anti-angiogenic isoforms of VEGF in health and disease

Articles

Gene therapy with vascular endothelial growth factors

Seppo Ylä-Herttuala

Biochem Soc Trans (2009) 37 (6): 1198–1200.

https://doi.org/10.1042/BST0371198

Published: 19 November 2009

...Seppo Ylä-Herttuala Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance...

View article titled, Gene therapy with vascular endothelial growth factors

Articles

Functionally defining the endothelial transcriptome, from Robo4 to ECSCR

Ana Raquel Verissimo, John M.J. Herbert, Victoria L. Heath, John A. Legg, Helen Sheldon, Maud Andre, Rajeeb Kumar Swain, Roy Bicknell

Biochem Soc Trans (2009) 37 (6): 1214–1217.

https://doi.org/10.1042/BST0371214

Published: 19 November 2009

... a critical role in endothelial biology and angiogenesis. Two such genes are the roundabout receptor Robo4 and the ECSCR (endothelial-cell-specific chemotaxis regulator). Endothelial cells express both Robo1 and Robo4, which we have knocked down using siRNA (small interfering RNA) and then studied the effect...

View article titled, Functionally defining the endothelial transcriptome, from Robo4 to ECSCR

Articles

A role for protein ubiquitination in VEGFR-2 signalling and angiogenesis

Nader Rahimi

Biochem Soc Trans (2009) 37 (6): 1189–1192.

https://doi.org/10.1042/BST0371189

Published: 19 November 2009

...Nader Rahimi Regulation of angiogenesis is often viewed as a balance between pro-angiogenic and anti-angiogenic factors, and when the balance shifts in favour of angiogenesis stimulators, an angiogenic switch turns on the normally inactive endothelial cells to grow new blood vessels. Recent studies...

View article titled, A role for protein ubiquitination in VEGFR-2 signalling and angiogenesis

Articles

VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis

Alexander F. Bruns, Leyuan Bao, John H. Walker, Sreenivasan Ponnambalam

Biochem Soc Trans (2009) 37 (6): 1193–1197.

https://doi.org/10.1042/BST0371193

Published: 19 November 2009

... in intracellular signalling pathways, cell migration and angiogenesis. Several potential VEGFR1-binding proteins have been identified using different systems, including the p85 subunit of phosphoinositide 3-kinase, PLCγ1 and adaptor proteins such as SHP2 (SH2 domain-containing protein tyrosine phosphatase 2), Grb2...

View article titled, VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis

Articles

The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis

Lorna R. Fiedler, Beata Wojciak-Stothard

Biochem Soc Trans (2009) 37 (6): 1243–1247.

https://doi.org/10.1042/BST0371243

Published: 19 November 2009

... associated with abnormal angiogenesis but the mechanisms are poorly understood. Recent studies show that altering ADMA metabolism in vivo and in vitro modulates the activity of Rho GTPases, key regulators of actin dynamics, endothelial cell motility and angiogenesis. In the present review, we consider...

View article titled, The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis

Articles

VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus

Johannes Waltenberger

Biochem Soc Trans (2009) 37 (6): 1167–1170.

https://doi.org/10.1042/BST0371167

Published: 19 November 2009

... basis of VEGF resistance in diabetes mellitus. 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth...

View article titled, VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus

Articles

Regulation of angiogenesis by ETS transcription factors

Anna M. Randi, Andrea Sperone, Nicola H. Dryden, Graeme M. Birdsey

Biochem Soc Trans (2009) 37 (6): 1248–1253.

https://doi.org/10.1042/BST0371248

Published: 19 November 2009

...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...

View article titled, Regulation of angiogenesis by ETS transcription factors

Articles

The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

Jörg Hartkamp, Stefan G.E. Roberts

Biochem Soc Trans (2008) 36 (4): 629–631.

https://doi.org/10.1042/BST0360629

Published: 22 July 2008

... cancer. 1 To whom correspondence should be addressed (email Joerg.Hartkamp@manchester.ac.uk ). 28 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 angiogenesis apoptosis development oncogene Wilms' tumour suppressor (WT1) The WT1 gene...

View article titled, The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only