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Keywords: angiogenesis
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Articles
Biochem Soc Trans (2019) 47 (5): 1543–1555.
Published: 11 October 2019
... matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action. Correspondence: Maurizo Mongiat ( mmongiat@cro.it ) or Renato V. Iozzo ( renato.iozzo@jefferson.edu ) 9 7 2019 22 8 2019 23 9 2019 © 2019...
Articles
Biochem Soc Trans (2018) 46 (6): 1673–1680.
Published: 04 December 2018
... under the Creative Commons Attribution License 4.0 (CC BY) . angiogenesis cadherins cell adhesion endothelial cells signalling Blood vessels form complex branched networks consisting of arteries, capillaries and veins that supply oxygen and nutrients to all body tissues [ 1...
Articles
Biochem Soc Trans (2016) 44 (4): 1142–1149.
Published: 15 August 2016
...Amaya García de Vinuesa; Matteo Bocci; Kristian Pietras; Peter ten Dijke Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway...
Articles
Biochem Soc Trans (2014) 42 (6): 1569–1575.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) Bevacizumab (Avastin®; Genentech/Roche) is a humanized monoclonal antibody that neutralizes all isoforms of VEGF-A with high specificity, thereby...
Articles
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
...Neil R. Smith; Stephen R. Wedge; Aurelien Pommier; Simon T. Barry There has been significant investment in developing novel therapies to target solid tumour vasculature. Different technical approaches have been utilized with the aim of inhibiting tumour angiogenesis or compromising the function...
Articles
Biochem Soc Trans (2014) 42 (6): 1590–1595.
Published: 17 November 2014
... the years, studies in β3-integrin-knockout mice have shed some light on possible explanations for disappointing clinical outcomes. However, studying angiogenesis in β3-integrin-knockout mice is a blunt tool to investigate β3-integrin's role in pathological angiogenesis. Since establishing our laboratory...
Articles
Biochem Soc Trans (2014) 42 (6): 1623–1628.
Published: 17 November 2014
...Anastasia Lampropoulou; Christiana Ruhrberg Blood vessel formation during vertebrate development relies on a process called angiogenesis and is essential for organ growth and tissue viability. In addition, angiogenesis leads to pathological blood vessel growth in diseases with tissue ischaemia...
Articles
Biochem Soc Trans (2014) 42 (6): 1563–1568.
Published: 17 November 2014
...Thaned Kangsamaksin; Ian W. Tattersall; Jan Kitajewski The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis. Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting, demonstrating that Notch regulates tip-stalk cell identity...
Articles
Biochem Soc Trans (2014) 42 (6): 1596–1600.
Published: 17 November 2014
...Gordon C. Jayson; Gavin J. Miller; Steen U. Hansen; Marek Barath; John M. Gardiner; Egle Avizienyte Angiogenesis has emerged as a novel target for anti-cancer therapies through randomized clinical trials that tested the benefit of adding vascular endothelial growth factor (VEGF) inhibitors...
Articles
Biochem Soc Trans (2014) 42 (6): 1658–1664.
Published: 17 November 2014
... regulator of angiogenesis. In this mini-review, we present an overview of the current literature on ELTD1 and present bioinformatics data showing ELTD1's sequence conservation, its expression in cancer cell lines and its mutational frequency in human cancers. Additionally, we present sequence homology...
Articles
Biochem Soc Trans (2014) 42 (6): 1629–1636.
Published: 17 November 2014
...Jaimy Saif; Costanza Emanueli miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review...
Articles
Biochem Soc Trans (2014) 42 (6): 1643–1646.
Published: 17 November 2014
... development; however, under conditions of challenge or insult, several phenotypes have emerged. Angiogenesis is an important process both in development and in wound healing, but also in pathologies such as cancer and chronic inflammatory conditions. In the present paper, we summarize the main studies...
Articles
Biochem Soc Trans (2014) 42 (6): 1665–1670.
Published: 17 November 2014
... stimulated the Wnt5a/sFlt-1 pathway through enhancing NF-κB signalling. These studies show a novel role for Glrx in post-ischaemic neovascularization, which could define a potential target for therapy of impaired angiogenesis in pathological conditions including diabetes. VEGF is the major factor...
Articles
Biochem Soc Trans (2014) 42 (6): 1608–1615.
Published: 17 November 2014
... angiogenesis inhibitors can only arise from two efforts. First, through the identification of better targets, preferably specifically expressed in the tumour vasculature. Secondly, through the development of combination therapies. The present review highlights the current efforts and challenges in trying...
Articles
Biochem Soc Trans (2014) 42 (6): 1584–1589.
Published: 17 November 2014
... cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. Active ERK5 is able to phosphorylate MEK5 [ 13 ] as well...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
... Society 2014 angiogenesis cilium endothelial cell phosphatidylinositol 3-phosphate (PI3K) phosphoinositide 3-kinase (PI3K) trafficking 1 To whom correspondence should be addressed (email t.maffucci@qmul.ac.uk ) . Phosphoinositide 3-kinases (PI3Ks) are lipid kinases...
Articles
Biochem Soc Trans (2014) 42 (5): 1429–1434.
Published: 18 September 2014
... expression die embryonically and show severe neuronal and cardiovascular defects. Even though the contribution of NRP1 to vascular development has been mainly ascribed to its function as a VEGF-A receptor, recent evidence suggests that NRP1 contributes to angiogenesis through VEGF-independent mechanisms...
Articles
Biochem Soc Trans (2014) 42 (3): 697–701.
Published: 22 May 2014
... angiogenesis muscle atrophy neuroprotection neurotrophic factor regeneration Peripheral nerve injuries, defined as those that affect any nerves outside the central nervous system, have been reported to affect 2.8% of trauma patients [ 1 ]. Injuries can range from compression of the nerve...
Articles
Biochem Soc Trans (2013) 41 (1): 273–276.
Published: 29 January 2013
... on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis. 1 To whom correspondence should be addressed (email Mattias.Belting@med.lu.se...
Articles
Biochem Soc Trans (2012) 40 (1): 20–25.
Published: 19 January 2012
... such as NRPs (neuropilins) associate with the ligand–receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue...
Articles
Biochem Soc Trans (2012) 40 (1): 251–256.
Published: 19 January 2012
... proliferative signalling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, reprogramming of energy metabolism, and evading immune destruction. These hallmarks are acquired by normal cells during tumour pathogenesis...
Articles
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... in the destabilization of this plaque. Cellular and molecular approaches are studied by in vitro assay of activated endothelial cells and in in vivo models of neovascularization. Chemokines are a large family of small secreted proteins that have been shown to play a critical role in the regulation of angiogenesis during...
Articles
Biochem Soc Trans (2011) 39 (6): 1606–1611.
Published: 21 November 2011
... reports of its role in endothelial cells and angiogenesis. Figure 2 Endothelial sprouting is regulated by RhoJ ( A ) HUVECs were transfected with RhoJ siRNA duplex 1 (D1), RhoJ siRNA duplex 2 (D2), negative control duplex (NCD) or mock-treated. At 2 days after transfection, cells were seeded...
Articles
Biochem Soc Trans (2011) 39 (6): 1571–1575.
Published: 21 November 2011
... correspondence should be addressed (email r.bicknell@bham.ac.uk ). Figure 1 Low shear stress induces expression of Robo4 and CLEC14A and initiates a tip cell phenotype from a phalanx cell Sprouting angiogenesis: formation of new blood vessels through degradation of basement membrane by proteases...
Articles
Biochem Soc Trans (2011) 39 (6): 1612–1618.
Published: 21 November 2011
...Chern Ein Oon; Adrian L. Harris Notch signalling is a key pathway controlling angiogenesis in normal tissues and tumours. This has become a major focus of development of anticancer therapy, but to develop this appropriately, we need further understanding of the mechanisms of regulation of Dll4...
Articles
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
...Stuart Egginton; Roy Bicknell Capillaries have been recognized for over a century as one of the most important components in regulating tissue oxygen transport, and their formation or angiogenesis a pivotal element of tissue remodelling during development and adaptation. Clinical interest stems...
Articles
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... mice [ 26 ]. These findings suggest a link between NRP1 and p130 Cas signalling which may play an important role in developmental angiogenesis. Future work on NRP1-specific signalling pathways should focus on p130 Cas and associated signalling networks involving Pyk2 and other p130 Cas -associated...
Articles
Biochem Soc Trans (2011) 39 (6): 1592–1596.
Published: 21 November 2011
...Harprit Singh; Tariq A. Tahir; Deborah O.A. Alawo; Eyad Issa; Nicholas P.J. Brindle The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1...
Articles
Biochem Soc Trans (2011) 39 (6): 1628–1632.
Published: 21 November 2011
...Thomas Gustafsson Exercise-induced angiogenesis in skeletal muscle involves both non-sprouting and sprouting angiogenesis and results from the integrated responses of multiple systems and stimuli. VEGF-A (vascular endothelial growth factor A) levels are increased in exercised muscle and have been...
Articles
Biochem Soc Trans (2011) 39 (6): 1597–1600.
Published: 21 November 2011
...Clare Hetheridge; Georgia Mavria; Harry Mellor Angiogenesis is a complex process that involves multiple cellular events. In addition to receiving inputs from a range of stimulatory and inhibitory factors, endothelial cells undergoing angiogenesis make multiple interactions with the extracellular...
Articles
Biochem Soc Trans (2011) 39 (6): 1659–1666.
Published: 21 November 2011
... the ENG (endoglin) or the ACVRL1 (activin receptor-like kinase 1) gene. Both genes are essential for angiogenesis during development and mice that are homozygous for mutations in Eng or Acvrl1 die in mid-gestation from vascular defects. Recent development of conditional mouse models in which the Eng...
Articles
Biochem Soc Trans (2011) 39 (6): 1601–1605.
Published: 21 November 2011
..., but were also found to be expressed in endothelial cells in the late 1990s. The early endothelial focus of PPARs was PPARγ, the molecular target for the insulin-sensitizing thiazolidinedione/glitazone class of drugs. Activation of PPARγ was shown to inhibit angiogenesis in vitro and in models...
Articles
Biochem Soc Trans (2011) 39 (6): 1560–1564.
Published: 21 November 2011
...Andreas Bikfalvi; Michel Moenner; Sophie Javerzat; Sophie North; Martin Hagedorn Angiogenesis has become a major target in cancer therapy. However, current therapeutic strategies have their limitations and raise several problems. In most tumours, anti-angiogenesis treatment targeting VEGF (vascular...
Articles
Biochem Soc Trans (2011) 39 (6): 1565–1570.
Published: 21 November 2011
... functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis...
Articles
Biochem Soc Trans (2011) 39 (5): 1376–1381.
Published: 21 September 2011
...Wei Zhuo; Xiaomin Song; Hao Zhou; Yongzhang Luo ADI (arginine deiminase), an enzyme that hydrolyses arginine, has been reported as an anti-angiogenesis agent. However, its molecular mechanism is unclear. We have demonstrated for the first time that ADI modulates the angiogenic activity...
Includes: Supplementary data
Articles
Biochem Soc Trans (2011) 39 (2): 688–693.
Published: 22 March 2011
... evelyn.murphy@ucd.ie ). 29 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 acute inflammation angiogenesis chronic inflammation cytokine macrophage polarization nuclear receptor Polarization and priming of immune cells are of significant importance...
Articles
Biochem Soc Trans (2009) 37 (6): 1233–1236.
Published: 19 November 2009
..., controlling arterial cell specification and tip versus stalk cell selection. During sprouting angiogenesis, tip cell formation is the default response to VEGF (vascular endothelial growth factor), whereas the stalk cell phenotype is acquired through Dll4/Notch-mediated lateral inhibition. Precisely how Notch...
Articles
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2009) 37 (6): 1207–1213.
Published: 19 November 2009
... associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys–Drash syndrome and pre-eclampsia). Administration of recombinant VEGF 165 b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma...
Articles
Biochem Soc Trans (2009) 37 (6): 1171–1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
Articles
Biochem Soc Trans (2009) 37 (6): 1254–1259.
Published: 19 November 2009
... is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2009) 37 (6): 1179–1183.
Published: 19 November 2009
...Caroline P.D. Wheeler-Jones; Charlotte Farrar; Elena Garonna COX (cyclo-oxygenase)-2 and members of the PAR (protease-activated receptor) family (PARs 1–4) are highly overexpressed in a number of angiogenesis-dependent pathologies, including advanced atherosclerosis and cancer. An appreciation...
Articles
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
...Seppo Ylä-Herttuala Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance...
Articles
Biochem Soc Trans (2009) 37 (6): 1189–1192.
Published: 19 November 2009
...Nader Rahimi Regulation of angiogenesis is often viewed as a balance between pro-angiogenic and anti-angiogenic factors, and when the balance shifts in favour of angiogenesis stimulators, an angiogenic switch turns on the normally inactive endothelial cells to grow new blood vessels. Recent studies...
Articles
Biochem Soc Trans (2009) 37 (6): 1214–1217.
Published: 19 November 2009
... a critical role in endothelial biology and angiogenesis. Two such genes are the roundabout receptor Robo4 and the ECSCR (endothelial-cell-specific chemotaxis regulator). Endothelial cells express both Robo1 and Robo4, which we have knocked down using siRNA (small interfering RNA) and then studied the effect...
Articles
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
... to sense a key cytokine in vascular tissues. angiogenesis endocytosis proteolysis receptor tyrosine kinase signalling vascular endothelial growth factor (VEGF) The vascular endothelium employs two cell-surface RTKs (receptor tyrosine kinases), VEGFR [VEGF (vascular endothelial growth factor...
Articles
Biochem Soc Trans (2009) 37 (6): 1243–1247.
Published: 19 November 2009
... associated with abnormal angiogenesis but the mechanisms are poorly understood. Recent studies show that altering ADMA metabolism in vivo and in vitro modulates the activity of Rho GTPases, key regulators of actin dynamics, endothelial cell motility and angiogenesis. In the present review, we consider...
Articles
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... of endothelial dysfunction are highlighted in Figure 1 (B). 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial...
Articles
Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
Articles
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
... cancer. 1 To whom correspondence should be addressed (email Joerg.Hartkamp@manchester.ac.uk ). angiogenesis apoptosis development oncogene Wilms' tumour suppressor (WT1) The WT1 gene was originally identified as a tumour suppressor involved in the formation of Wilms' tumour...