...Emma L. Clark; Frances V. Fuller-Pace; David J. Elliott; Craig N. Robson The mechanisms involved in the transition from androgen-dependent to androgen-independent PCa (prostate cancer) remain largely undefined. The AR (androgen receptor) is an androgen-dependent transcription factor and is thought...

...S.M. Powell; G.N. Brooke; H.C. Whitaker; V. Reebye; S.C. Gamble; D. Chotai; D.A. Dart; B. Belandia; C.L. Bevan Anti-androgens used in prostate cancer therapy inhibit AR (androgen receptor) activity via largely unknown mechanisms. Although initially successful in most cases, they eventually fail...

...G. Verrijdt; T. Tanner; U. Moehren; L. Callewaert; A. Haelens; F. Claessens The AR (androgen receptor) is a hormone-dependent transcription factor that translates circulating androgen hormone levels into a physiological cellular response by directly regulating the expression of its target genes...

... family are involved in NR-mediated signalling. Supervillin is capable of interacting in an androgen-enhanced fashion with the AR (androgen receptor) [ 12 ], and assays in mammalian cells showed that supervillin can enhance AR-mediated expression of reporter genes and can co-operate with other AR co...