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Keywords: amyotrophic lateral sclerosis
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Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
...Gareth S.A. Wright The efficacy of superoxide dismutase-1 (SOD1) folding impacts neuronal loss in motor system neurodegenerative diseases. Mutations can prevent SOD1 post-translational processing leading to misfolding and cytoplasmic aggregation in familial amyotrophic lateral sclerosis (ALS...
Biochem Soc Trans (2016) 44 (1): 197–201.
Published: 09 February 2016
... with diacylglycerol (DAG) and PtdOH. Through these interactions, Nir2 functions in ER–PM contact zones. Mutations in VAP-B that have been identified in familial forms of amyotrophic lateral sclerosis (ALS or Lou-Gehrig's disease) cause aggregation of the VAP-B protein, which then impairs its binding to several...
Biochem Soc Trans (2014) 42 (5): 1270–1274.
Published: 18 September 2014
...Laura Ferraiuolo Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the motor nerves. At present, there is no effective therapy for this devastating disease and only one Food and Drug Administration (FDA)-approved drug, riluzole, is known to moderately extend...
Biochem Soc Trans (2014) 42 (5): 1291–1301.
Published: 18 September 2014
... Alzheimer’s disease amyotrophic lateral sclerosis glia Huntington’s disease neurodegeneration Parkinson’s disease Neuroglia, represented by highly heterogeneous population of non-excitable cells of ectodermal/neural (astroglia, oligodendroglia and NG-2 glia) and mesodermal/myeloid (microglia...
Biochem Soc Trans (2005) 33 (4): 551–552.
Published: 01 August 2005
... address: Department of Physiology, The Royal College of Surgeons in Ireland, York House, York St., Dublin 2, Ireland. 2 To whom correspondence should be addressed (email l.greensmith@ion.ucl.ac.uk ). 22 3 2005 © 2005 The Biochemical Society 2005 amyotrophic lateral sclerosis...