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Keywords: amyloidosis
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Biochem Soc Trans (2010) 38 (2): 466–470.
Published: 22 March 2010
... system) disorders. For TTR (transthyretin) amyloidosis, we are seeking small molecule compounds that stabilize the amyloidogenic protein and either prevent its structural transition to the crossed β fibres deposited in diseased tissues, or promote its clearance from circulation. Effective stabilizer...