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Keywords: amyloid precursor proteinClose
Biochem Soc Trans (2023) 51 (4): 1647–1659.
Published: 30 June 2023
...Dennis Dik-Long Chau; Laura Lok-Haang Ng; Yuqi Zhai; Kwok-Fai Lau Amyloid precursor protein (APP) is a key molecule in the pathogenesis of Alzheimer's disease (AD) as the pathogenic amyloid-β peptide is derived from it. Two closely related APP family proteins (APPs) have also been identified...
Biochem Soc Trans (2023) 51 (1): 173–182.
Published: 23 January 2023
...Heather M. Wilkins Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria...
Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
... 11 2015 © 2016 Authors; published by Portland Press Limited 2016 amyloid precursor protein PIKfyve phosphatidylinositol-3 5-bisphosphate trafficking Alzheimer's disease Vac14 Fig4 Fab1 Phosphoinositides are important components of cellular membranes. What sets them apart...
Biochem Soc Trans (2008) 36 (6): 1299–1303.
Published: 19 November 2008
.... However, research has identified a more logical reason to group some of these diseases together. The associated proteins not only aggregate, but also bind copper. The APP (amyloid precursor protein) binds copper in an N-terminal region. Binding of copper has been suggested to influence generation of β...
Biochem Soc Trans (2006) 34 (4): 607–611.
Published: 21 July 2006
... neuroprotective effects for the treatment of neurodegenerative diseases. Like amyloid precursor protein and Notch, p75 is a substrate for γ-secretase cleavage. The p75 receptor undergoes an α-secretase-mediated release of the extracellular domain followed by a γ-secretase-mediated intramembrane cleavage. Cleavage...
Biochem Soc Trans (2005) 33 (2): 335–338.
Published: 01 April 2005
...N.M. Hooper In the amyloidogenic pathway, the APP (amyloid precursor protein) is proteolytically processed by the β- and γ-secretases to release the Aβ (amyloid-β) peptide that is neurotoxic and aggregates in the brains of patients suffering from Alzheimer's disease. In the non-amyloidogenic...
Biochem Soc Trans (2000) 28 (4): 441–446.
Published: 01 August 2000
...N. M. Hooper; A. J. Turner Angiotensin-converting enzyme (ACE) and the Alzheimer's disease amyloid precursor protein are two examples of membrane-bound proteins that are released in a soluble form by a post-trans-lational proteolytic cleavage event involving a secretase. Site-specific antibodies...