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Keywords: amyloid precursor protein
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Biochem Soc Trans (2008) 36 (6): 1299–1303.
Published: 19 November 2008
.... However, research has identified a more logical reason to group some of these diseases together. The associated proteins not only aggregate, but also bind copper. The APP (amyloid precursor protein) binds copper in an N-terminal region. Binding of copper has been suggested to influence generation of β...
Biochem Soc Trans (2006) 34 (4): 607–611.
Published: 21 July 2006
... neuroprotective effects for the treatment of neurodegenerative diseases. Like amyloid precursor protein and Notch, p75 is a substrate for γ-secretase cleavage. The p75 receptor undergoes an α-secretase-mediated release of the extracellular domain followed by a γ-secretase-mediated intramembrane cleavage. Cleavage...
Biochem Soc Trans (2000) 28 (4): 441–446.
Published: 01 August 2000
...N. M. Hooper; A. J. Turner Angiotensin-converting enzyme (ACE) and the Alzheimer's disease amyloid precursor protein are two examples of membrane-bound proteins that are released in a soluble form by a post-trans-lational proteolytic cleavage event involving a secretase. Site-specific antibodies...