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1-36 of 36
Keywords: alternative splicing
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221347.
Published: 24 May 2023
... in human cancer more frequently than any other oncogene. The KRAS pre-mRNA is alternatively spliced to generate two transcripts, KRAS4A and KRAS4B , that encode distinct proto-oncoproteins that differ almost exclusively in their C-terminal hypervariable regions (HVRs) that controls subcellular trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221131.
Published: 05 May 2023
... 2023 25 4 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 alternative splicing exon-junction complexes nonsense-mediated decay RNA decay translation Nonsense-mediated RNA decay (NMD) is a quality control process...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 31–39.
Published: 25 January 2023
... ( karel.riha@ceitec.muni.cz ) or Vivek K. Raxwal ( vivek.raxwal@ceitec.muni.cz ) 14 11 2022 11 1 2023 13 1 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 alternative splicing Arabidopsis thaliana nonsense-mediated decay...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1417–1425.
Published: 19 October 2016
... Press Limited on behalf of the Biochemical Society 2016 alternative splicing eukaryotic gene expression HIV RNA metabolism SR proteins Human immunodeficiency virus type 1 (HIV-1) is a member of the retrovirus family of positive-strand RNA viruses that reverse transcribe their genomic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1185–1200.
Published: 19 October 2016
... will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease...
Articles
Miguel B. Coelho, David B. Ascher, Clare Gooding, Emma Lang, Hannah Maude, David Turner, Miriam Llorian, Douglas E.V. Pires, Jan Attig, Christopher W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1058–1065.
Published: 15 August 2016
... (to D.B.A. and D.E.V.P.)]; the Fundação de Amparo à Pesquisa do Estado de Minas Gerais [grant number MR/M026302/1 (to D.B.A. and D.E.V.P.)]; and the National Health and Medical Research Council CJ Martin Fellowship [grant number APP1072476 (to D.B.A.)]. AS alternative splicing ASE alternative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1066–1072.
Published: 15 August 2016
... targets in the CNS (central nervous system). 1 To whom correspondence should be addressed (email ingrid.ehrmann@ncl.ac.uk ). 31 3 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 alternative splicing CNS (central nervous...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1079–1085.
Published: 15 August 2016
... being a ‘splicing noise’, co-expression is often established through co-ordinated activity of specific cis -elements and trans -acting factors. Further work in this area may uncover new biological functions of alternative splicing (AS) and generate important insights into mechanisms allowing different...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (6): 1241–1246.
Published: 27 November 2015
... of the downstream N-ras gene, is tissue and developmental stage-dependent and is repressed by c-Myc and Max (Myc associated factor X). Alternative splicing gives rise to six transcript variants, which include three different 5′-UTRs. The transcripts are further diversified by the use of three alternative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1180–1183.
Published: 11 August 2014
... alternative splicing regulation and steroid receptors transcriptional activity. Its ability to regulate specific splicing profiles depending on context has been related to different expression levels of the RBFOX2 protein itself and that of other splicing regulatory proteins involved in the shared modulation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1141–1146.
Published: 11 August 2014
...Mikael Feracci; Jaelle Foot; Cyril Dominguez STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1196–1205.
Published: 11 August 2014
...Christopher R. Sibley Alternative splicing is universally accredited for expanding the information encoded within the transcriptome. In recent years, several tightly regulated alternative splicing events have been reported which do not lead to generation of protein products, but lead to unstable...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1147–1151.
Published: 11 August 2014
... Society 2014 alternative splicing ELAV/Hu family proteins nucleocytoplasmic shuttling phosphorylation RNA-binding protein ELAV (embryonic lethal/abnormal visual system)/Hu family proteins are important regulators of neuronal RNA processing and are implicated in alternative splicing...
Articles
Andrew Best, Caroline Dalgliesh, Mahsa Kheirollahi-Kouhestani, Marina Danilenko, Ingrid Ehrmann, Alison Tyson-Capper, David J. Elliott
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Figure 1 Tra2 proteins are nuclear RNA-binding proteins ( A ) Human Tra2β is found within the general nucleoplasm and also in nuclear speckles. Here localization of Tra2β (green) is shown in the nucleus...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
... or modification (such as methylation), alternative splicing, 3′ end processing, mRNA localization, translation and decay. Together, the arsenal of regulatory elements within the non-coding portion of the genome allows the fine-balanced gene expression appropriate to each cell type in our body, and enables...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1593–1597.
Published: 20 November 2013
... tetraspanin has been proposed, as it contains a U12 snRNP-dependent intron that is poorly spliced in animal models of the disease [ 15 ]. ALS amyotrophic lateral sclerosis AS alternative splicing CNS central nervous system FUS fused in sarcoma hnRNP heterogeneous nuclear...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 768–772.
Published: 20 July 2012
...Claudia Tammaro; Michela Raponi; David I. Wilson; Diana Baralle BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... expression to ensure efficient virus replication. For example, the viral transcription factor E2 can directly up-regulate, in an epithelial differentiation-dependent manner, cellular SRSFs [SR (serine/arginine-rich) splicing factors] that control constitutive and alternative splicing. Changes in alternative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 804–809.
Published: 20 July 2012
...Yash Hemani; Matthias Soller Alternative splicing of pre-mRNA is a major mechanism to increase protein diversity in higher eukaryotes. Dscam , the Drosophila homologue of human DSCAM (Down's syndrome cell adhesion molecule), generates up to 38016 isoforms through mutually exclusive splicing in four...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 677–680.
Published: 20 July 2012
...Michael Niblock; Jean-Marc Gallo Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain. Several MAPT mutations causing the familial tauopathy, FTDP-17 (frontotemporal dementia...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 870–874.
Published: 20 July 2012
...Rachel M. Hagen; Michael R. Ladomery AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have...
Articles
Panagiota Kafasla, Ian Mickleburgh, Miriam Llorian, Miguel Coelho, Clare Gooding, Dmitry Cherny, Amar Joshi, Olga Kotik-Kogan, Stephen Curry, Ian C. Eperon, Richard J. Jackson, Christopher W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 815–820.
Published: 20 July 2012
... with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of some ASEs (alternative splicing events), and as an activator of translation driven by IRESs...
Articles
Fernando G. Osorio, Alejandro P. Ugalde, Guillermo Mariño, Xose S. Puente, José M.P. Freije, Carlos López-Otín
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... of specific genes [ 54 ]. alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1122–1124.
Published: 26 July 2010
... © 2010 Biochemical Society 2010 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) nervous system development RNA-binding proteins comprise a major class in the proteome of eukaryotes. Important functions for RNA-binding proteins...
Articles
Craig G. Simpson, Sujatha Manthri, Katarzyna Dorota Raczynska, Maria Kalyna, Dominika Lewandowska, Branislav Kusenda, Monika Maronova, Zofia Szweykowska-Kulinska, Artur Jarmolowski, Andrea Barta, John W.S. Brown
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 667–671.
Published: 22 March 2010
...Craig G. Simpson; Sujatha Manthri; Katarzyna Dorota Raczynska; Maria Kalyna; Dominika Lewandowska; Branislav Kusenda; Monika Maronova; Zofia Szweykowska-Kulinska; Artur Jarmolowski; Andrea Barta; John W.S. Brown AS (alternative splicing) is a post-transcriptional process which regulates gene...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
... zipcode-binding protein 1 alternative splicing cross-linking and immunoprecipitation (CLIP) microRNA (miRNA) ribosome profiling synaptic plasticity UV-cross-linking Diverse post-transcriptional mechanisms allow a cell to precisely control the proteins to be synthesized at different...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1311–1315.
Published: 19 November 2009
...Cathy J. Jensen; Brian J. Oldfield; Justin P. Rubio Splicing is a post-transcriptional modification of RNA during which introns are removed and exons are joined. Most of the mammalian genes undergo constitutive and alternative splicing events. In addition to the strong signals of the splice sites...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 641–647.
Published: 22 July 2008
... regulates these disparate processes. 31 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing internal ribosome entry site (IRES) IRES trans -acting factor (ITAF) polypyrimidine-tract-binding protein (PTB) RNA-binding protein RNA recognition...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
... of these different physiological mRNAs remains to be explored. In addition to nonsense and frameshift mutations in the DNA that result in the synthesis of mRNAs with PTCs, a large amount of PTC-containing mRNAs arise from alternative pre-mRNA splicing [ 8 ]. With regard to alternative splicing representing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 502–504.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) erect wing gene ( ewg gene) evolution nervous system development ELAV (embryonic lethal abnormal visual system) from...
Articles
Craig G. Simpson, Dominika Lewandowska, John Fuller, Monika Maronova, Maria Kalyna, Diane Davidson, Jim McNicol, Dorota Raczynska, Artur Jarmolowski, Andrea Barta, John W.S. Brown
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 508–510.
Published: 21 May 2008
...Craig G. Simpson; Dominika Lewandowska; John Fuller; Monika Maronova; Maria Kalyna; Diane Davidson; Jim McNicol; Dorota Raczynska; Artur Jarmolowski; Andrea Barta; John W.S. Brown The impact of AS (alternative splicing) is well-recognized in animal systems as a key regulator of gene expression...
Articles
Andrew P. Harrison, Joanna Rowsell, Renata da Silva Camargo, William B. Langdon, Maria Stalteri, Graham J.G. Upton, Jose M. Arteaga-Salas
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 511–513.
Published: 21 May 2008
... (Newcastle, U.K.). Calca calcitonin/calcitonin-related polypeptide α CGRP calcitonin gene-related peptide GEO Gene Expression Omnibus Affymetrix GeneChip alternative polyadenylation alternative splicing microarray post-transcriptional processing RNA Microarrays...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 89–90.
Published: 22 January 2007
... by intracellular Mg 2+ ions. Besides these rather common features, in which TRPM3 channels resemble the closely related channels TRPM6 and TRPM7, TRPM3 channels have several unique characteristics. The TRPM3 gene encodes a plethora of different proteins owing to alternative splicing and alternative exon usage. One...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 443–446.
Published: 01 June 2005
... of post-transcriptional gene expression. 1 To whom correspondence should be addressed (email Javier.Caceres@hgu.mrc.ac.uk ). 13 1 2005 © 2005 The Biochemical Society 2005 alternative splicing pre-mRNA splicing RNA processing RS domain small nuclear ribonucleoprotein (RNP...
Articles
R. Spellman, A. Rideau, A. Matlin, C. Gooding, F. Robinson, N. McGlincy, S.N. Grellscheid, J. Southby, M. Wollerton, C.W.J. Smith
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 457–460.
Published: 01 June 2005
...R. Spellman; A. Rideau; A. Matlin; C. Gooding; F. Robinson; N. McGlincy; S.N. Grellscheid; J. Southby; M. Wollerton; C.W.J. Smith PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing. We have investigated the role of PTB in three model alternative splicing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 171–176.
Published: 01 May 2001
... receptors, laminin and neural cell-adhesion molecules. Three major classes of UNC-52/perlecan isoforms are produced through alternative splicing, and these distinct proteins exhibit complex spatial and temporal expression patterns throughout development. The unc-52 gene plays an essential role...
