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Keywords: allostery
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Articles
Biochem Soc Trans (2018) 46 (5): 1333–1343.
Published: 09 October 2018
... G protein structures, allostery and dynamics will be essential for the design and testing of the next generation of inhibitors, both orthosteric and allosteric, as well as for understanding their mode of action. Correspondence: Helen R. Mott ( hrm28@cam.ac.uk ) 27 7 2018 31 8 2018...
Articles
Biochem Soc Trans (2014) 42 (1): 139–144.
Published: 23 January 2014
... of York, U.K., 17–19 June 2013. Organized and Edited by Nicholas Brindle (University of Leicester, U.K.), Sandip Patel (University College London, U.K.) and Stephen Yarwood (University of Glasgow, U.K.) allostery cAMP cGMP covariance NMR protein dynamics singular value decomposition (SVD...
Articles
Biochem Soc Trans (2012) 40 (5): 975–980.
Published: 19 September 2012
...Hesam N. Motlagh; Jing Li; E. Brad Thompson; Vincent J. Hilser Allostery is a biological phenomenon of critical importance in metabolic regulation and cell signalling. The fundamental premise of classical models that describe allostery is that structure mediates ‘action at a distance’. Recently...
Articles
Biochem Soc Trans (2012) 40 (3): 523–530.
Published: 22 May 2012
... (ribonucleoside diphosphates) [ 11 ]. In addition to having a complex catalytic mechanism, RNRs employ sophisticated allostery to maintain the appropriate nucleotide balance in the cell (recently summarized in [ 12 ]). In the present paper, we focus on the Escherichia coli enzyme, which has long served...
Articles
Biochem Soc Trans (2012) 40 (3): 475–491.
Published: 22 May 2012
.... allostery dynamics oligomerization p53 protein complex quaternary structure The modularity of biological systems facilitates their representation as networks, enabling the use of graph theory to systematically and quantitatively analyse these highly complex systems. Protein systems networks can...
Articles
Biochem Soc Trans (2012) 40 (1): 219–223.
Published: 19 January 2012
... allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states J. Am. Chem. Soc. 2007 129 14482 14492 8 Das R. Mazhab-Jafari M.T. Chowdhury S. SilDas S. Selvaratnam R. Melacini G. Entropy-driven cAMP-dependent...
Articles
Biochem Soc Trans (2011) 39 (2): 425–429.
Published: 22 March 2011
...’ enantiomer in engineered mutant enzymes and implications for resolution of racemates. 1 email paul.engel@ucd.ie The possibility of mutagenesis also offered ways to explore allostery. It became clear that nothing smaller than a hexamer was active [ 25 , 29 , 30 ] and so our approach...
Articles
Biochem Soc Trans (2011) 39 (1): 294–298.
Published: 19 January 2011
... compilation © 2011 Biochemical Society 2011 allostery cAMP receptor protein–fumarate and nitrate reductase regulatory protein (CRP–FNR) dissimilative nitrate respiration regulator (DNR) nitric oxide Pseudomonas aeruginosa transcription factor NO (nitric oxide) is a cellular messenger...
Articles