... G protein structures, allostery and dynamics will be essential for the design and testing of the next generation of inhibitors, both orthosteric and allosteric, as well as for understanding their mode of action. Correspondence: Helen R. Mott ( hrm28@cam.ac.uk ) 27 7 2018 31 8 2018...

...-relieving mutations. 1 To whom correspondence should be addressed (email melacin@mcmaster.ca ). 13 11 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 Allostery is a central mechanism of regulation in biological systems. Although initially discovered...

...Hesam N. Motlagh; Jing Li; E. Brad Thompson; Vincent J. Hilser Allostery is a biological phenomenon of critical importance in metabolic regulation and cell signalling. The fundamental premise of classical models that describe allostery is that structure mediates ‘action at a distance’. Recently...

... to surprise us after all these years. 14 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 allostery conformational equilibrium feedback regulation nucleotide biosynthesis oligomerization protein–protein interaction In all organisms, propagation...

... correspondence should be addressed (email sat@mrc-lmb.cam.ac.uk ). 1 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 allostery dynamics oligomerization p53 protein complex quaternary structure Over the last two decades, it has become clear that most...

... of the allosteric network shown in ( a ). Selected regions subject to cAMP-dependent structural and dynamic changes are shown with a green and red ribbon respectively. Reproduced with permission from [ 17 ]: Selvaratnam, R., Chowdhury, S., VanSchouwen, B. and Melacini, G. (2011) Mapping allostery through...

...’ enantiomer in engineered mutant enzymes and implications for resolution of racemates. 21 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 allostery amino acid dehydrogenase Clostridium symbiosum glutamate dehydrogenase hybrid oligomer negative co-operativity...

... data, a suggested activation mechanism is discussed. 1 To whom correspondence should be addressed (email serena.rinaldo@uniroma1.it ). 13 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 allostery cAMP receptor protein–fumarate and nitrate...

... the mechanism of activation of GABA B receptor and examine any possible role of GABA B2 . activation mechanism allostery dimerization γ-aminobutyric acid-B (GABA B ) receptor G-protein-coupled receptor (GPCR) heptahelical domain The GPCRs form a large family of membrane proteins responsible...