.... allosteric regulation bacterial transcription regulation diphtheria toxin repressor iron homeostasis iron-dependent regulator metal-sensing transcription factor In the early 1990s the groups of Holmes and Murphy identified a transcription factor which represses expression of the diphtheria toxin...

... of kinase substrates. Here, we review mechanisms of allosteric regulation of protein kinases and recent advances in the field. allosteric regulation drug discovery and design kinases Eukaryotic protein kinases regulate a wide array of cellular processes through the catalytic transfer...

... of Arizona in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. allosteric regulation DNA endonuclease enzyme mechanism enzymology filamentation restriction endonuclease Filamentation of central metabolic and biosynthetic enzymes...

.... A better understanding of the role of IMPDH1 in the retina and the characterization of an animal disease model will be critical for determining the molecular mechanism of IMPDH1-associated blindness. allosteric regulation retinitis pigmentosa splice variants Inosine-5′-monophosphate...

...Chen Davidovich; Qi Zhang Histone lysine methyltransferases (HKMTs) are key regulators of many cellular processes. By definition, HKMTs catalyse the methylation of lysine residues in histone proteins. The enzymatic activities of HKMTs are under precise control, with their allosteric regulation...

... 2021 15 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 allosteric regulation computational biochemistry molecular dynamics Aromatic amino acids phenylalanine (Phe), tyrosine (Tyr), and tryptophan (Trp) are important...

.... In addition, allosteric regulation further fine-tunes the catalytic activity of SAMHD1, with a nucleotide-activated homotetramer as the catalytically active form of the protein. In cells, GTP and dATP are the likely physiological activators of two adjacent allosteric sites, AL1 (GTP) and AL2 (dATP...

...: John W Scott ( jscott@svi.edu.au ) 15 2 2019 31 3 2019 2 4 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 allosteric regulation AMPK metabolic regulation small molecules Critical to the survival of all...

... Liang ( zxliang@ntu.edu.sg ) 14 11 2018 2 1 2019 8 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 allosteric regulation cellulose synthase cyclic di-GMP flagella PilZ domain protein–protein interactions...

... allosteric regulation fractals protein conformation protein dynamics Allostery is a process that regulates the activity of enzymes via binding a modulator at a distal site, sterically different from the chemically active site. It is now well recognized that allostery is a fundamental property...

... Press Limited on behalf of the Biochemical Society 2017 allosteric regulation complex IV conformational change proton pathways The mechanism by which C c O (cytochrome c oxidase) reduces oxygen to water and conserves the free energy released by this reaction in the form of a proton...

...-catalytic functions that can be exerted by conventional protein kinases. allosteric regulation protein–protein interactions pseudoenzyme pseudokinases signalling Counterparts of active enzymes that lack key catalytic residues and are therefore predicted to possess defective catalytic...

... of the Biochemical Society 2017 allosteric regulation azobenzene molecular machine photoswitch protein engineering The fundamental basis of the ‘molecular tweezer’ engineering strategy lies in the photo-physical properties of the azobenzene group. It exists in two isomerization states...

...) and a potential allosteric regulator at the pseudosymmetric site (depicted in white). These cavities are collapsed in the inactive crystal structure ( D ). The catalytic core of sGC is composed of two homologous domains. The active site lies at the interface between the two domains. Ligand binding...

... for allosteric regulation of GPCRs by sodium ions Science 2012 337 232 236 40 Lebon G. Warne T. Edwards P.C. Bennett K. Langmead C.J. Leslie A.G. Tate C.G. Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation Nature 2011 474 521...

... structures provide fertile ground for allosteric regulation [ 37 ]. Exploiting the potential of this pocket to manipulate kinase conformation, and not just to block activity, is consequently of critical importance as we move forward in the targeting of kinases in disease. mTOR Signalling in Health...

...,6BP, fructose 1,6-bisphosphate allosteric regulation drug design effector site fructose 2,6-bisphosphate trypanosomatid Biochemical Society Transactions (2000) Volume 28, part 2 acyl-CoA. The enzyme properties and locations are consistent with this. Above all, the carnitine derivatives...