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Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
...Sarah Rolli; Emily Mitchell Sontag Properly folded, functional proteins are essential for cell health. Cells sustain protein homeostasis, or proteostasis, via protein quality control (PQC) mechanisms. It is currently hypothesized that a breakdown in proteostasis during ageing leads...
Biochem Soc Trans (2021) 49 (6): 2853–2869.
Published: 16 December 2021
...Katrina Woodward; Nikolay E. Shirokikh Cellular ageing is one of the main drivers of organismal ageing and holds keys towards improving the longevity and quality of the extended life. Elucidating mechanisms underlying the emergence of the aged cells as well as their altered responses...
Biochem Soc Trans (2020) 48 (2): 367–377.
Published: 20 March 2020
...Claudia Lennicke; Helena M. Cochemé Ageing and age-related diseases are major challenges for the social, economic and healthcare systems of our society. Amongst many theories, reactive oxygen species (ROS) have been implicated as a driver of the ageing process. As by-products of aerobic metabolism...
Biochem Soc Trans (2014) 42 (4): 922–927.
Published: 11 August 2014
... of altered distribution and expression during ageing and disease. We have investigated previously whether extracellular T-cell or peripheral blood mononuclear cell Trx-1 levels serve as a robust marker of ageing. In a preliminary study of healthy older adults compared with younger adults, we showed...
Helen R. Griffiths, Christopher R. Dunston, Stuart J. Bennett, Melissa M. Grant, Darren C. Phillips, George D. Kitas
Biochem Soc Trans (2011) 39 (5): 1273–1278.
Published: 21 September 2011
...Helen R. Griffiths; Christopher R. Dunston; Stuart J. Bennett; Melissa M. Grant; Darren C. Phillips; George D. Kitas During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox...