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Keywords: adaptive response
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Biochem Soc Trans (2020) 48 (3): 1101–1108.
Published: 07 May 2020
... of genomic aberration. Although adaptive responses results in drug resistance, it also induces therapeutic vulnerabilities that could be exploited with rational combination therapies. To fulfill this role, we established the combinatorial adaptive response therapy (CART) platform by performing reverse-phase...
Biochem Soc Trans (2019) 47 (1): 209–217.
Published: 21 December 2018
... transcription factors and the DNA; (ii) short periods of time when RNA polymerase is able to access the promoter due to conformational changes in the DNA structure; and (iii) retention of the sigma factor at the promoter and the subsequent reinitiation of transcription [ 14 ]. adaptive response bacteria...