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Keywords: acute myeloid leukaemia
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Biochem Soc Trans (2021) 49 (6): 2561–2572.
Published: 02 December 2021
... in these genes in cancer were long thought to lead to a ‘loss of function’, combined genomic and metabolomic studies led to the discovery that a common IDH 1 mutation, present in low-grade glioma and acute myeloid leukaemia (AML), yields a variant (R132H) with a striking change of function leading...