...: fibroblast coupling may influence the electrical activity of the myocyte and contribute to arrhythmias. action potential cardiac myocyte: fibroblast coupling connexin fibrosis gap junction ischaemia The trigger for cardiac contraction begins in the sinoatrial node (SAN), where electrical...

...S.M. Mizielinska Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation...

...T. Scheuer; W.A. Catterall Currents through voltage-gated sodium channels drive action potential depolarization in neurons and other excitable cells. Smaller currents through these channels are key components of currents that control neuronal firing and signal integration. Changes in sodium current...