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Keywords: actin
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Articles
Biochem Soc Trans (2021) 49 (2): 685–692.
Published: 19 March 2021
...Elena E. Grintsevich Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark...
Articles
Biochem Soc Trans (2018) 46 (6): 1463–1473.
Published: 21 November 2018
... RP is a frequently reported phenotype. Recent studies have highlighted an intimate relationship between cilia and the actin cystoskeleton. This review will focus on the role of actin in photoreceptors, examining the connection between actin dysregulation in RP. Correspondence: Toby W. Hurd...
Articles
Biochem Soc Trans (2018) 46 (3): 565–576.
Published: 20 April 2018
... each step, the actin cytoskeleton contributes to all. However, its role can be indirect to the actual molecular events driving endocytosis. Here, we review our understanding of the molecular steps mediating local actin polymerization during the formation of endocytic carriers. Clathrin-mediated...
Articles
Biochem Soc Trans (2016) 44 (6): 1701–1708.
Published: 02 December 2016
...Tadamoto Isogai; Metello Innocenti Formin family proteins (formins) represent an evolutionary conserved protein family encoded in the genome of a wide range of eukaryotes. Formins are hallmarked by a formin homology 1 (FH1) domain juxtaposed to an FH2 domain whereby they control actin...
Articles
Biochem Soc Trans (2016) 44 (5): 1339–1345.
Published: 19 October 2016
...Joe J. Tyler; Ellen G. Allwood; Kathryn R. Ayscough Wiskott–Aldrich syndrome protein (WASP) family proteins have been extensively characterized as factors that promote the nucleation of actin through the activation of the protein complex Arp2/3. While yeast mostly have a single member of the family...
Articles
Biochem Soc Trans (2016) 44 (4): 1026–1034.
Published: 15 August 2016
..., at least one class 2 gene and classes 5, 6, 9, 10, 18 and 19. Although the different myosin isoforms all have specific and non-overlapping roles in the cell, in combination they all contribute to the organization of the actin cytoskeleton, and the shape and phenotype of the cell. Over (or under) expression...
Articles
Biochem Soc Trans (2015) 43 (1): 84–91.
Published: 26 January 2015
...J. Victor Small Actin polymerization is harnessed by cells to generate lamellipodia for movement and by a subclass of pathogens to facilitate invasion of their infected hosts. Using electron tomography (ET), we have shown that lamellipodia are formed via the generation of subsets of actin filaments...
Articles
Biochem Soc Trans (2014) 42 (6): 1534–1537.
Published: 17 November 2014
... the interplay between these processes. Integrin-mediated interaction with the actin cytoskeleton is a known regulator of cell adhesion and migration and there is emerging evidence that this pathway may also be essential for cytokinesis. We discuss evidence that a known actin-binding region in PKCε is involved...
Articles
Biochem Soc Trans (2014) 42 (6): 1506–1511.
Published: 17 November 2014
.... 1 email husem@mskcc.org 17 7 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 actin cell polarity microtubule protein kinase C (PKC) signal transduction T-cell These two cytoskeletal remodelling events serve as the foundation...
Articles
Biochem Soc Trans (2014) 42 (5): 1356–1366.
Published: 18 September 2014
...Josefine Starke; Bernhard Wehrle-Haller; Peter Friedl Mobile cells discriminate and adapt to mechanosensory input from extracellular matrix (ECM) topographies to undergo actin-based polarization, shape change and migration. We tested ‘cell-intrinsic’ and adaptive components of actin-based cell...
Includes: Supplementary data
Articles
Biochem Soc Trans (2013) 41 (6): 1750–1754.
Published: 20 November 2013
.... Although dozens of different molecules localize to and participate within the cytokinetic ring, the core machinery comprises linear actin filaments. Accordingly, formins, which nucleate and elongate F-actin (filamentous actin) for the cytokinetic ring, are required for cytokinesis in diverse species...
Articles
Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
... protein) and parvin, forming the IPP (ILK–PINCH–parvin) complex that regulates the integrin–actin linkage as well as microtubule dynamics. These functions are essential for processes such as cell migration and matrix remodelling. The present review discusses the recent advances on the structural...
Articles
Biochem Soc Trans (2012) 40 (6): 1416–1420.
Published: 21 November 2012
... that the yeast class V myosin, Myo4p, transports mRNAs along actin cables into the growing bud, and now several groups have reported a similar role for class V myosins in higher eukaryotes. Myosin Va has also been implicated in the assembly and maintenance of P-bodies (processing bodies), cytoplasmic foci...
Articles
Biochem Soc Trans (2011) 39 (5): 1115–1119.
Published: 21 September 2011
... in general. 1 To whom correspondence should be addressed (email fb1@mole.bio.cam.ac.uk ). 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin exocytosis fusion myosin secretion vesicle Secretion/exocytosis is a fundamental mechanism...
Articles
Biochem Soc Trans (2011) 39 (5): 1136–1141.
Published: 21 September 2011
... with myosin 6, and there is evidence to show that this motor can dimerize if brought into close proximity on actin or in the presence of certain myosin 6-binding proteins [ 45 , 46 ]. There are two MyTH4–FERM domains and an SH3 domain in the tail of myosin 7a, both of which are known to function as binding...
Articles
Biochem Soc Trans (2011) 39 (2): 568–573.
Published: 22 March 2011
... not stimulate ligand-independent activation of ErbB receptors in epithelial cells. However, integrin-dependent adhesion potentiated ligand-induced activation of EGFR (epidermal growth factor receptor) and ErbB2 and facilitated receptor homo- and hetero-dimerization. The actin cytoskeleton appeared to play...
Articles
Biochem Soc Trans (2010) 38 (3): 755–760.
Published: 24 May 2010
... at the cell cortex and what is known about its assembly and trafficking. actin cellulose synthase complex cell wall endoplasmic reticulum Golgi body microtubule plant 1 To whom correspondence should be addressed (email simon.turner@manchester.ac.uk ). 14 12 2009 ©...
Articles
Biochem Soc Trans (2010) 38 (3): 823–828.
Published: 24 May 2010
...Tijs Ketelaar; Hannie S. van der Honing; Anne Mie C. Emons In interphase plant cells, the actin cytoskeleton is essential for intracellular transport and organization. To fully understand how the actin cytoskeleton functions as the structural basis for cytoplasmic organization, both molecular...
Articles
Biochem Soc Trans (2010) 38 (3): 833–838.
Published: 24 May 2010
... in the tissues studied in Arabidopsis and tobacco [ 9 , 14 , 19 , 37 , 46 , 47 ]. Drug inhibition studies, either through depolymerizing the actin cytoskeleton or treatment with BDM, have indicated that organelle movement in plants is dependent on acto-myosin: Golgi [ 26 , 27 ], peroxisomes [ 28 – 30...
Articles
Biochem Soc Trans (2010) 38 (1): 181–186.
Published: 19 January 2010
... that multiple factors may be involved in exocytic–endocytic coupling including SV integral membrane proteins, SV membrane lipids and the membrane-associated actin cytoskeleton. A number of recent studies also indicate that multimodular adaptor proteins shuttling between the active and periactive zones aid...
Articles
Biochem Soc Trans (2009) 37 (5): 966–970.
Published: 21 September 2009
...Margarita V. Chibalina; Claudia Puri; John Kendrick-Jones; Folma Buss There is now increasing evidence that myosin motor proteins, together with the dynamic actin filament machinery and associated adhesion proteins, play crucial roles in the events leading to motility at the leading edge...
Articles
Biochem Soc Trans (2009) 37 (5): 961–965.
Published: 21 September 2009
... needed, and the balance between tubular and lamellar regions can be altered. The distribution and organization of the ER depends on both motile and static interactions with microtubules and the actin cytoskeleton. In the present paper, we review how the ER moves, and consider why this movement may...
Articles
Biochem Soc Trans (2008) 36 (6): 1359–1367.
Published: 19 November 2008
... also have N-terminal actin-binding CH (calponin homology) domains. The genes encoding the three vertebrate nesprins (five in bony fish) and the small transmembrane actin-binding protein calmin are related to each other by ancient duplications and rearrangements. In the present paper, we collate...
Includes: Supplementary data
Articles
Biochem Soc Trans (2008) 36 (3): 425–430.
Published: 21 May 2008
... modelling to formulate and test a simple hypothesis for the assembly of the contractile ring. This model involves the formation of 65 nodes containing myosin-II and formin Cdc12p around the equator of the cell. As a cell enters anaphase, actin filaments grow from formin Cdc12p in these nodes. Myosin...
Articles
Biochem Soc Trans (2008) 36 (2): 149–155.
Published: 20 March 2008
... in the organization of the actin cytoskeleton. Although cadherins were thought to bind directly to the actin cytoskeleton through cytoplasmic proteins, termed α- and β-catenin, recent studies with purified proteins indicate that the interaction is not direct, and instead an allosteric switch in α-catenin may mediate...
Articles
Biochem Soc Trans (2008) 36 (2): 141–147.
Published: 20 March 2008
...Sabine Pokutta; Frauke Drees; Soichiro Yamada; W. James Nelson; William I. Weis Cadherins are transmembrane adhesion molecules that mediate homotypic cell–cell contact. In adherens junctions, the cytoplasmic domain of cadherins is functionally linked to the actin cytoskeleton through a series...
Articles
Biochem Soc Trans (2007) 35 (4): 683–685.
Published: 20 July 2007
... trafficking and secretion. The cytoskeleton is also critical for communication; for example, alterations to the architecture of the F-actin (filamentous actin) cytoskeletal networks can affect communication between the cells and the extracellular matrix, potentially compromising tissue homoeostasis. Although...
Articles
Biochem Soc Trans (2006) 34 (4): 550–553.
Published: 21 July 2006
... with their telomeres to the nuclear envelope and undergo oscillating movements that become restricted to a limited nuclear sector during the widely conserved bouquet stage. Recent observations in budding yeast meiosis suggest that telomere clustering depends on actin, whereas exit from the bouquet stage requires...
Articles
Biochem Soc Trans (2005) 33 (6): 1243–1246.
Published: 26 October 2005
...N. Ibarra; A. Pollitt; R.H. Insall Actin reorganization is a tightly regulated process that co-ordinates complex cellular events, such as cell migration, chemotaxis, phagocytosis and adhesion, but the molecular mechanisms that underlie these processes are not well understood. SCAR (suppressor...
Articles
Biochem Soc Trans (2005) 33 (6): 1254–1255.
Published: 26 October 2005
...J.R. Higginson; S.J. Winder Dystroglycan, a ubiquitous membrane-spanning cell adhesion molecule, is a crucial link between the actin cytoskeleton and the extracellular matrix. With a wide expression pattern and multiple interacting proteins, not only is dystroglycan now thought to be important...
Articles
Biochem Soc Trans (2005) 33 (6): 1250–1253.
Published: 26 October 2005
...G. Danuser We study how mechanical forces integrate spatially and temporally with regulatory signals at the leading edge of migrating cells. To probe the dynamics of this system, we developed quantitative fluorescent speckle microscopy, which maps out actin cytoskeleton transport, assembly...
Articles
Biochem Soc Trans (2005) 33 (6): 1256–1259.
Published: 26 October 2005
...A. Schirenbeck; R. Arasada; T. Bretschneider; M. Schleicher; J. Faix Filopodia are finger-like cell protrusions composed of parallel arrays of actin filaments, which elongate through actin polymerization at their tips. These highly dynamic structures seem to be used by many cell types as sensing...
Articles
Biochem Soc Trans (2005) 33 (6): 1260–1264.
Published: 26 October 2005
...C.W. Gourlay; K.R. Ayscough The actin cytoskeleton is central to many cell processes including membrane trafficking and generation of cell polarity. We have identified a role for actin in cell death and in promoting longevity of the budding yeast, Saccharomyces cerevisiae . Aging in yeast appears...
Articles
Biochem Soc Trans (2005) 33 (5): 891–895.
Published: 26 October 2005
...A. Hall Rho, Rac and Cdc42, three members of the Rho family of small GTPases, each control a signal transduction pathway linking membrane receptors to the assembly and disassembly of the actin cytoskeleton and of associated integrin adhesion complexes. Rho regulates stress fibre and focal adhesion...
Articles
Biochem Soc Trans (2004) 32 (5): 685–688.
Published: 26 October 2004
...I. Lister; R. Roberts; S. Schmitz; M. Walker; J. Trinick; C. Veigel; F. Buss; J. Kendrick-Jones Myosin VI moves towards the minus end of actin filaments unlike all the other myosins so far studied, suggesting that it has unique properties and functions. Myosin VI is present in clathrin-coated pits...
Articles
Biochem Soc Trans (2004) 32 (6): 1115–1117.
Published: 26 October 2004
...S. Passey; S. Pellegrin; H. Mellor Many cell types can generate thin actin-based protrusive structures, which are often classified under the general term of ‘filopodia’. However, a range of filopodia-like structures exists that differ both morphologically and functionally. In this brief review, we...