... and covalently attached to diverse amino acid side chains and consequently modulate protein function. For example, acetylation of Lys residues can alter the charge state of proteins and generate new recognition elements for protein–protein interactions. Alternatively, long-chain fatty-acylation targets proteins...

... the dynamics and stability of the microtubule system via its bundling and tubulin acetylation-promoting activities. These physiological functions are mediated by its direct associations with tubulin/microtubules as well as tubulin deacetylases such as histone deacetylase (HDAC) 6. In a normal brain, TPPP/p25...

...Lei Shi; Benjamin P. Tu Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications...

... compilation © 2013 Biochemical Society 2013 acetylation DNA methylation epigenetics histone hydoxymethylation Epigenetics is the study of changes in gene expression which occur in the absence of mutation, but are mitotically inheritable. Epigenetics was first put forward as an idea...

... of cyclin A degradation in the light of recent evidence indicating that acetylation plays a role in cyclin A stability. The emerging model proposes that the acetyltransferase PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] [perhaps also its homologue GCN5 (general...

... answer to a variety of stimuli and return to its initial stage when the stimuli disappear. acetylation cancer histone acetyltransferase (HAT) p53 post-translational modification ubiquitylation Altogether, the functional connections described above between ubiquitylation and acetylation...

... phosphorylation and acetylation and reveal that certain lysine residues are marked for SUMOylation by negatively charged amino acid residues or phosphorylation events immediately downstream of the consensus site. In the present review, we explore the intriguing role of extended motifs in the regulation of SUMO...

... acetylation is the well-established epigenetic regulator for gene expression. Recent studies show that different patterns of PTMs and cross-talk of individual modifications (acetylation, methylation, phosphorylation) are keys of gene regulation (known as the ‘histone code’). As well as histone, non-histone...

.... 1 e-mail tk106@mole.bio.cam.ac.uk 14 May 2003 © 2003 Biochemical Society 2003 acetylation cancer chromatin chromatin-modifying enzyme histone transcription Abbreviations used: CARM1, co-activator-associated arginine methyltransferase 1; HDAC, histone deacetylase...

..., adhesion molecules, and inflammatory enzymes and receptors. Increased expression of inflammatory genes is regulated by pro-inflammatory transcription factors, such as nuclear factor κB (NF-κB). These bind to, and activate, co-activator molecules that then acetylate core histones resulting in elevated gene...