... significant mechanism in intact cells. 1 To whom correspondence should be addressed (email d.g.hardie@dundee.ac.uk ). 14 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 acetyl-CoA carboxylase (ACC) AMP-activated protein kinase (AMPK) Ca 2+ /calmodulin...

...R.W. Brownsey; A.N. Boone; J.E. Elliott; J.E. Kulpa; W.M. Lee Acetyl-CoA carboxylase (ACC) catalyses the formation of malonyl-CoA, an essential substrate for fatty acid synthesis in lipogenic tissues and a key regulatory molecule in muscle, brain and other tissues. ACC contributes importantly...

... surplus and inactive during nutrient deficit, e.g. the fasted state. Our most recent evidence (described below) validates this hypothesis. Scheme 1 The malonyl-CoA hypothesis acetyl-CoA carboxylase (ACC) C75 fatty acid synthase (FAS) hypothalamus intracerebroventricular (i.c.v...

... 2005 © 2005 The Biochemical Society 2005 acetyl-CoA carboxylase (ACC) 2-enoyl-thioester reductase 3-hydroxyacyl-thioester dehydratase mitochondrial fatty acid synthesis respiratory competent mitochondrion yeast The FAS (fatty acid synthesis) type II pathway has been typically...

... content, exercise training and fibre type. In summary, AMPK regulates several metabolic pathways during acute exercise and modifies the expression of many genes involved in the adaptive changes to exercise training. acetyl-CoA carboxylase (ACC) AMP-activated protein kinase (AMPK) fatty acid oxidation...