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Articles

Structure determination of transient transcription complexes

Patrick Cramer

Biochem Soc Trans (2016) 44 (4): 1177–1182.

DOI: https://doi.org/10.1042/BST20160079

Published: 15 August 2016

... machineries of Pol I and Pol III [ 6 ]. cryo-electron microscopy eukaryotic RNA polymerase complex integrated structural biology multiprotein assembly X-ray crystallography © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 29 3 2016...

View article titled, Structure determination of transient transcription complexes

Articles

Dynamic structural science: recent developments in time-resolved spectroscopy and X-ray crystallography

Jose Trincao, Michelle L. Hamilton, Jeppe Christensen, Arwen R. Pearson

Biochem Soc Trans (2013) 41 (5): 1260–1264.

DOI: https://doi.org/10.1042/BST20130125

Published: 23 September 2013

... correspondence should be addressed (email a.r.pearson@leeds.ac.uk ). 26 6 2013 © 2013 The Authors 2013 laser spectroscopy synchrotron time-resolved spectroscopy X-ray crystallography To fully understand a biochemical process, it is necessary to observe not only the resting state...

View article titled, Dynamic structural science: recent developments in time-resolved spectroscopy and X-ray crystallography

Articles

A long road towards the structure of respiratory complex I, a giant molecular proton pump

Leonid A. Sazanov, Rozbeh Baradaran, Rouslan G. Efremov, John M. Berrisford, Gurdeep Minhas

Biochem Soc Trans (2013) 41 (5): 1265–1271.

DOI: https://doi.org/10.1042/BST20130193

Published: 23 September 2013

... © 2013 The Authors 2013 bioenergetics complex I membrane protein structure NADH:ubiquinone oxidoreductase respiratory chain X-ray crystallography Complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) plays a central role in the respiratory chain in mitochondria and many bacteria...

View article titled, A long road towards the structure of respiratory complex I, a giant molecular proton pump

Articles

Structural characterization of the cyclin-dependent protein kinase family

Jane A. Endicott, Martin E.M. Noble

Biochem Soc Trans (2013) 41 (4): 1008–1016.

DOI: https://doi.org/10.1042/BST20130097

Published: 18 July 2013

... and regulation. 1 To whom correspondence should be addressed (email jane.endicott@ncl.ac.uk ). 3 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cell cycle cyclin cyclin-dependent kinase (CDK) phosphorylation transcription X-ray crystallography...

View article titled, Structural characterization of the cyclin-dependent protein kinase family

Articles

Photoactivated structural dynamics of fluorescent proteins

Dominique Bourgeois, Aline Regis-Faro, Virgile Adam

Biochem Soc Trans (2012) 40 (3): 531–538.

DOI: https://doi.org/10.1042/BST20120002

Published: 22 May 2012

... can be monitored by combining X-ray crystallography, in crystallo optical spectroscopy and simulation tools such as quantum chemistry/molecular mechanics hybrid approaches. Besides their usefulness to rationally engineer better performing fluorescent proteins for nanoscopy and other biotechnological...

View article titled, Photoactivated structural dynamics of fluorescent proteins

Articles

Deciphering how the chromatin factor RCC1 recognizes the nucleosome: the importance of individuals in the scientific discovery process

Song Tan

Biochem Soc Trans (2012) 40 (2): 351–356.

DOI: https://doi.org/10.1042/BST20110734

Published: 21 March 2012

... and rationale during the discovery process. 1 email sxt30@psu.edu 6 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 chromatin histone acetyltransferase (HAT) molecular recognition nucleosome X-ray crystallography If DNA is the blueprint of life...

View article titled, Deciphering how the chromatin factor RCC1 recognizes the nucleosome: the importance of individuals in the scientific discovery process

Articles

Biochemical contacts and collaborations between China and the U.K. since 1911

Guy G. Dodson

Biochem Soc Trans (2011) 39 (5): 1313–1322.

DOI: https://doi.org/10.1042/BST0391313

Published: 21 September 2011

...@ysbl.york.ac.uk 23 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Chinese biochemistry Chinese–U.K. research collaboration insulin U.K. biochemistry X-ray crystallography Figure 7 Dorothy Hodgkin and Fred Sanger, Cambridge, 1984, at the 50th anniversary...

View article titled, Biochemical contacts and collaborations between China and the U.K. since 1911

Articles

Insulin research in China and the U.K.

Youshang Zhang

Biochem Soc Trans (2011) 39 (5): 1323–1326.

DOI: https://doi.org/10.1042/BST0391323

Published: 21 September 2011

... biochemistry Chinese–U.K. research collaboration insulin U.K. biochemistry X-ray crystallography On the occasion of the Centenary of the founding of Biochemical Society, the Joint Sino–U.K. Protein Symposium was held in Shanghai in May 2011. In the present article, I focus on insulin research...

View article titled, Insulin research in China and the U.K.

Articles

Mapping lipid and detergent molecules at the surface of membrane proteins

Richard J. Cogdell, Alastair T. Gardiner, Aleksander W. Roszak, Sigitas Stončius, Pavel Kočovský, Neil W. Isaacs

Biochem Soc Trans (2011) 39 (3): 775–779.

DOI: https://doi.org/10.1042/BST0390775

Published: 20 May 2011

... photosynthetic bacterium X-ray crystallography Figure 4 The Br-LDAO-binding site at the surface of RC from Blc. viridis The 2 F o − F c electron density at 1.0σ level (blue) and F o − F c electron density at 3.0σ level (green) as found in the initial maps calculated for the 1.85 Å (1 Å=0.1 nm...

View article titled, Mapping lipid and detergent molecules at the surface of membrane proteins

Articles

Combining X-ray crystallography and single-crystal spectroscopy to probe enzyme mechanisms

Arwen R. Pearson, Robin L. Owen

Biochem Soc Trans (2009) 37 (2): 378–381.

DOI: https://doi.org/10.1042/BST0370378

Published: 20 March 2009

...Arwen R. Pearson; Robin L. Owen The combination of X-ray crystallography and rapid cryo-trapping methods has enabled the visualization of catalytic intermediates in a variety of enzyme systems. However, the resolution of the X-ray experiment is not always sufficient to precisely place the structure...

View article titled, Combining X-ray crystallography and single-crystal spectroscopy to probe enzyme mechanisms

Articles

Cytochrome c 6A : discovery, structure and properties responsible for its low haem redox potential

Jonathan A.R. Worrall, Ben F. Luisi, Beatrix G. Schlarb-Ridley, Derek S. Bendall, Christopher J. Howe

Biochem Soc Trans (2008) 36 (6): 1175–1179.

DOI: https://doi.org/10.1042/BST0361175

Published: 19 November 2008

... salient difference between the haem pockets is that a valine residue in cytochrome c 6A replaces a highly conserved glutamine residue in cytochrome c 6 . This difference has been probed using site-directed mutagenesis, X-ray crystallography and protein film voltammetry studies. It has been found...

View article titled, Cytochrome c 6A : discovery, structure and properties responsible for its low haem redox potential

Articles

Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Bostjan Kobe, Gregor Guncar, Rebecca Buchholz, Thomas Huber, Bohumil Maco, Nathan Cowieson, Jennifer L. Martin, Mary Marfori, Jade K. Forwood

Biochem Soc Trans (2008) 36 (6): 1438–1441.

DOI: https://doi.org/10.1042/BST0361438

Published: 19 November 2008

... (macromolecular X-ray crystallography) is the most popular method to obtain high-resolution structural information on protein–protein complexes, and it yields the most detailed structural information about the interaction. However, there is a major issue when using MX to study protein–protein interactions...

View article titled, Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Articles

Electroneutral and electrogenic catalysis by dihaem-containing succinate:quinone oxidoreductases

C. Roy D. Lancaster, Elena Herzog, Hanno D. Juhnke, M. Gregor Madej, Florian G. Müller, Rajsekhar Paul, Philipp G. Schleidt

Biochem Soc Trans (2008) 36 (5): 996–1000.

DOI: https://doi.org/10.1042/BST0360996

Published: 19 September 2008

... atomic model fumarate reductase membrane protein succinate dehydrogenase transmembrane electrochemical proton potential X-ray crystallography This electrogenic catalysis indeed appeared to be the case for some dihaem-containing representatives of the superfamily of QFRs and SQRs...

View article titled, Electroneutral and electrogenic catalysis by dihaem-containing succinate:quinone oxidoreductases

Articles

What we have learned from ribosome structures

V. Ramakrishnan

Biochem Soc Trans (2008) 36 (4): 567–574.

DOI: https://doi.org/10.1042/BST0360567

Published: 22 July 2008

... codon–anticodon pairing decoding ribosome RNA X-ray crystallography Ribosomes are large macromolecular assemblies consisting of approx. two-thirds by mass of RNA, with the rest being proteins. Given their molecular mass of approx. 2.5 MDa in bacteria, it was not clear whether it would ever...

View article titled, What we have learned from ribosome structures

Articles

Structural studies on desmosomes

Ashraf Al-Amoudi, Achilleas S. Frangakis

Biochem Soc Trans (2008) 36 (2): 181–187.

DOI: https://doi.org/10.1042/BST0360181

Published: 20 March 2008

... cadherin molecules interacting at their N-terminal tips. An integrative structural approach involving X-ray crystallography, cryo-electron tomography and immuno-electron microscopy should give the complete picture of the architecture of this important junction; identifying its various proteins and showing...

View article titled, Structural studies on desmosomes

Articles

Coarse-grained simulation: a high-throughput computational approach to membrane proteins

Mark S.P. Sansom, Kathryn A. Scott, Peter J. Bond

Biochem Soc Trans (2008) 36 (1): 27–32.

DOI: https://doi.org/10.1042/BST0360027

Published: 22 January 2008

... simulation coarse-grained simulation high-throughput computational approach membrane protein Molecular Dynamics X-ray crystallography Membrane proteins are of considerable biomedical importance, accounting for approx. 25% of genes [ 1 ] and forming a major class of drug targets. Although...

View article titled, Coarse-grained simulation: a high-throughput computational approach to membrane proteins

Articles

Recent structural studies of RNA polymerases II and III

P. Cramer

Biochem Soc Trans (2006) 34 (6): 1058–1061.

DOI: https://doi.org/10.1042/BST0341058

Published: 25 October 2006

... in the Pol III modelling because of weak or apparently lacking sequence conservation with its Pol III counterpart C17/25. We therefore determined the C17/25 structure by X-ray crystallography. The structure of C25 resembles that of its counterparts Rpb7 and RpoE. The structure of C17 reveals a compact N...

View article titled, Recent structural studies of RNA polymerases II and III

Articles

Lipids in and around photosynthetic reaction centres

P.K. Fyfe, M.R. Jones

Biochem Soc Trans (2005) 33 (5): 924–930.

DOI: https://doi.org/10.1042/BST0330924

Published: 26 October 2005

... the membrane lipids. X-ray crystallography has provided high-resolution structures for PS-I and the purple bacterial reaction centre, and revealed binding sites for a number of lipids, either embedded in the protein interior or attached to the protein surface. These lipids play a variety of roles, including...

View article titled, Lipids in and around photosynthetic reaction centres

Articles

Chemical insights from structural studies of enzymes

J.H. Naismith

Biochem Soc Trans (2004) 32 (5): 647–654.

DOI: https://doi.org/10.1042/BST0320647

Published: 26 October 2004

... 2004 The Biochemical Society 2004 deoxy sugar NADH rhamnose X-ray crystallography The structures identify that a single, absolutely conserved histidine residue is positioned below the plane of the ring, and is in the correct location to abstract a proton from C3′ or C5′. This histidine...

View article titled, Chemical insights from structural studies of enzymes

Articles

Single protein molecular dynamics determined with ultra-high precision

Y.C. Sasaki

Biochem Soc Trans (2004) 32 (5): 761–763.

DOI: https://doi.org/10.1042/BST0320761

Published: 26 October 2004

... dynamics X-ray crystallography All X-ray techniques are based on the averaged measurements of many molecules or atoms. Thus the behaviours of individual single protein molecules cannot be determined using X-rays. In this work, we demonstrated the direct observations of the rotating motions...

View article titled, Single protein molecular dynamics determined with ultra-high precision

Articles

X-ray crystallographic studies of protein–ligand interactions

R.A. Palmer, H. Niwa

Biochem Soc Trans (2003) 31 (5): 973–979.

DOI: https://doi.org/10.1042/bst0310973

Published: 01 October 2003

...R.A. Palmer; H. Niwa X-ray crystallography enables details of covalent and non-covalent interactions to be analysed quantitatively in three dimensions, thus providing the basis for the understanding of binding of ligands to proteins as well as modes of action such as cell-surface binding...

View article titled, X-ray crystallographic studies of protein–ligand interactions

Articles

Structure of human BPI (bactericidal/permeability-increasing protein) and implications for related proteins

L.J. Beamer

Biochem Soc Trans (2003) 31 (4): 791–794.

DOI: https://doi.org/10.1042/bst0310791

Published: 01 August 2003

... ligands. They also lack any apparent enzymic activity. Concurrent with the rapid increase in available genomic sequence data in recent years, it has become apparent that the LTP/LPS-binding proteins are part of a much larger family Key words: BPI, homology modelling, X-ray crystallography. Abbreviations...

View article titled, Structure of human BPI (bactericidal/permeability-increasing protein) and implications for related proteins

Articles

A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose

C. Dong, K. Beis, M.-F. Giraud, W. Blankenfeldt, S. Allard, L.L. Major, I.D. Kerr, C. Whitfield, J.H. Naismith

Biochem Soc Trans (2003) 31 (3): 532–536.

DOI: https://doi.org/10.1042/bst0310532

Published: 01 June 2003

...). Of the amino acids, only glycine, serine and cysteine have a similar ratio. Further, each position is often asymmetric, adding further diversity. In organic chemical terms this has meant that the Key words: enzyme structure, sugar, X-ray crystallography. Abbreviation used: LBHB, low-barrier hydrogen bond...

View article titled, A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose

Articles

Nicotinic acetylcholine receptors: α-conotoxins as templates for rational drug design

Robert W. Janes

Biochem Soc Trans (2003) 31 (3): 634–636.

DOI: https://doi.org/10.1042/bst0310634

Published: 01 June 2003

... Focused Meeting held at AstraZeneca R&D Charnwood, Loughborough, 24–25 February 2003 11 February 2003 © 2003 Biochemical Society 2003 computational docking study conotoxin molecular topology X-ray crystallography Abbreviations used: ACh, acetylcholine; nAChR...

View article titled, Nicotinic acetylcholine receptors: α-conotoxins as templates for rational drug design

Articles

Oxygen activation in a copper-containing amine oxidase

C.M. Wilmot

Biochem Soc Trans (2003) 31 (3): 493–496.

DOI: https://doi.org/10.1042/bst0310493

Published: 01 June 2003

... plasma. Recently the CuAO located in adipocyte membranes has been linked to glucose transport via the GLUT-4 pathway [5 10]. Key words: catalytic intermediate, copper-containing amine oxidase, oxygen activation, quinoprotein, X-ray crystallography. Abbreviations used: CuAO, copper-containing amine...

View article titled, Oxygen activation in a copper-containing amine oxidase

Articles

Structural insights into the evolution of the pantothenate-biosynthesis pathway

C.M.C. Lobley, F. Schmitzberger, M.L. Kilkenny, H. Whitney, H.H. Ottenhof, E. Chakauya, M.E. Webb, L.M. Birch, K.L. Tuck, C. Abell, A.G. Smith, T.L. Blundell

Biochem Soc Trans (2003) 31 (3): 563–571.

DOI: https://doi.org/10.1042/bst0310563

Published: 01 June 2003

... University, 12–14 January 2003 16 December 2002 © 2003 Biochemical Society 2003 enzyme pathway evolution pantothenate X-ray crystallography Abbreviations used: KPHMT, ketopantoate hydroxymethyltransferase; KPR, ketopantoate reductase; ADC, aspartate decarboxylase; PS...

View article titled, Structural insights into the evolution of the pantothenate-biosynthesis pathway

Articles

Human carboxylesterase 1: from drug metabolism to drug discovery

M.R. Redinbo, S. Bencharit, P.M. Potter

Biochem Soc Trans (2003) 31 (3): 620–624.

DOI: https://doi.org/10.1042/bst0310620

Published: 01 June 2003

... metabolism, cocaine, heroin, human carboxylesterase 1 inhibitor, X-ray crystallography. Abbreviations used: hCE1, human carboxylesterase 1; CEH, cholesteryl ester hydrolase; ACAT, acyl-CoA:cholesterol acyltransferase; ER, endoplasmic reticulum; CRP, C-reactive protein; rCE, rabbit carboxylesterase; AcChE...

View article titled, Human carboxylesterase 1: from drug metabolism to drug discovery

Articles

A two-faced molecule offers NO explanation: the proximal binding of nitric oxide to haem

D.M. Lawson, C.E.M. Stevenson, C.R. Andrew, S.J. George, R.R. Eady

Biochem Soc Trans (2003) 31 (3): 553–557.

DOI: https://doi.org/10.1042/bst0310553

Published: 01 June 2003

... is activated up to 200-fold by the binding of NO to the haem, whereas the binding of CO gives rise to only a mild stimulation of activity. Through X-ray crystallography we have studied NO and CO binding to cyt c ´. CO binds to the distal face to give a 6-coordinate (6c) adduct. By contrast, NO binding gives...

View article titled, A two-faced molecule offers NO explanation: the proximal binding of nitric oxide to haem

Articles

Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin

G.A. Holdgate, W.H.J. Ward, F. McTaggart

Biochem Soc Trans (2003) 31 (3): 528–531.

DOI: https://doi.org/10.1042/bst0310528

Published: 01 June 2003

..., cholesterol-lowering, enzyme inhibition, isothermal titration calori- metry, statin, X-ray crystallography. Abbreviations used: E.I, enzyme inhibitor complex; E.I , second E.I complex in a two- step mechanism; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; HMG-CoAR, HMG-CoA reductase; K i , inhibition constant...

View article titled, Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin

Articles

Cofactor processing in galactose oxidase

S.J. Firbank, M. Rogers, R. Hurtado-Guerrero, D.M. Dooley, M.A. Halcrow, S.E.V. Phillips, P.F. Knowles, M.J. McPherson

Biochem Soc Trans (2003) 31 (3): 506–509.

DOI: https://doi.org/10.1042/bst0310506

Published: 01 June 2003

... – A Structural Perspective, a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 6 January 2003 © 2003 Biochemical Society 2003 cofactor biogenesis copper galactose oxidase post-translational processing X-ray crystallography Abbreviations...

View article titled, Cofactor processing in galactose oxidase

Articles

Three-dimensional structure and flexibility of proteins of the RCA family — a progress report

A. Herbert, J. O'Leary, M. Krych-Goldberg, J. P. Atkinson, P. N. Barlow

Biochem Soc Trans (2002) 30 (6): 990–996.

DOI: https://doi.org/10.1042/bst0300990

Published: 01 November 2002

...-mail Paul.Barlowa@ac.uk ) 18 6 2002 © 2002 Biochemical Society 2002 complement module multiple domain NMR X-ray crystallography CCP, complement control protein module CR, complement receptor: HSQC, heteronuclear single-quantum coherence: LHR, long homologous repeat: MCP, membrane...

View article titled, Three-dimensional structure and flexibility of proteins of the RCA family — a progress report

Articles

Ribozymes, the first 20 years

T. R. Cech

Biochem Soc Trans (2002) 30 (6): 1162–1166.

DOI: https://doi.org/10.1042/bst0301162

Published: 01 November 2002

... through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein...

View article titled, Ribozymes, the first 20 years

Articles

Structural studies of the Fur protein from Rhizobium leguminosarum

O. O. Kolade, P. Bellini, M. Wexler, A. W. B. Johnston, J. G. Grossmann, A. M. Hemmings

Biochem Soc Trans (2002) 30 (4): 771–774.

DOI: https://doi.org/10.1042/bst0300771

Published: 01 August 2002

... solution X-ray scattering X-ray crystallography Fur, ferric-uptake regulatory protein HTH, helix-tum-helix Biometals 2002: Third International Biometals Symposium: Focused Meeting Organized by S. Andrews (School of Animal and Microbial Sciences, University of Reading), R. Cammack, R. W...

View article titled, Structural studies of the Fur protein from Rhizobium leguminosarum

Articles

5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism

P. M. Shoolingin-Jordan, P. Spencer, M. Sarwar, P. E. Erskine, K.-M. Cheung, J. B. Cooper, E. B. Norton

Biochem Soc Trans (2002) 30 (4): 584–590.

DOI: https://doi.org/10.1042/bst0300584

Published: 01 August 2002

... in the recovery of substantial enzyme activity. The effects of the site-directed alkylating inhibitor, 5-chlorolaevulinic acid, and 4,7-dioxosebacic acid, a putative intermediate analogue, were investigated by X-ray crystallography. These inhibitors reacted with both active-site lysine residues. The role...

View article titled, 5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism

Articles

Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

M. A. Lemmon, K. M. Ferguson

Biochem Soc Trans (2001) 29 (4): 377–384.

DOI: https://doi.org/10.1042/bst0290377

Published: 01 August 2001

... correspondence should be addressed (e-mail mlemmon@mail.med.upenn.edu ) 16 3 2001 © 2001 Biochemical Society 2001 PH domains phosphoinositide-binding sites phosphoinositide 3-kinase X-ray crystallography Btk, Bruton's tyrosine kinase DAPPI, d ual a daptor for p hosphotyrosine...

View article titled, Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

Articles

Plant peroxidases: substrate complexes with mechanistic implications

M. Gajhede

Biochem Soc Trans (2001) 29 (2): 91–99.

DOI: https://doi.org/10.1042/bst0290091

Published: 01 May 2001

... evidence. 1 E-mail gajhede@psg.ki.ku.dk 21 12 2000 © 2001 Biochemical Society 2001 structure X-ray crystallography BHA, benzhydroxamic acid HRP C, horseradish peroxidase C FA, ferulic acid CCP, cytochrome c peroxidase ARP, Arthromyces ramosus peroxidase n 0...

View article titled, Plant peroxidases: substrate complexes with mechanistic implications

NARROW

Structure determination of transient transcription complexes

Dynamic structural science: recent developments in time-resolved spectroscopy and X-ray crystallography

A long road towards the structure of respiratory complex I, a giant molecular proton pump

Structural characterization of the cyclin-dependent protein kinase family

Photoactivated structural dynamics of fluorescent proteins

Deciphering how the chromatin factor RCC1 recognizes the nucleosome: the importance of individuals in the scientific discovery process

Biochemical contacts and collaborations between China and the U.K. since 1911

Insulin research in China and the U.K.

Mapping lipid and detergent molecules at the surface of membrane proteins

Combining X-ray crystallography and single-crystal spectroscopy to probe enzyme mechanisms

Cytochrome c 6A : discovery, structure and properties responsible for its low haem redox potential

Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Electroneutral and electrogenic catalysis by dihaem-containing succinate:quinone oxidoreductases

What we have learned from ribosome structures

Structural studies on desmosomes

Coarse-grained simulation: a high-throughput computational approach to membrane proteins

Recent structural studies of RNA polymerases II and III

Lipids in and around photosynthetic reaction centres

Chemical insights from structural studies of enzymes

Single protein molecular dynamics determined with ultra-high precision

X-ray crystallographic studies of protein–ligand interactions

Structure of human BPI (bactericidal/permeability-increasing protein) and implications for related proteins

A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose

Nicotinic acetylcholine receptors: α-conotoxins as templates for rational drug design

Oxygen activation in a copper-containing amine oxidase

Structural insights into the evolution of the pantothenate-biosynthesis pathway

Human carboxylesterase 1: from drug metabolism to drug discovery

A two-faced molecule offers NO explanation: the proximal binding of nitric oxide to haem

Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin

Cofactor processing in galactose oxidase

Three-dimensional structure and flexibility of proteins of the RCA family — a progress report

Ribozymes, the first 20 years

Structural studies of the Fur protein from Rhizobium leguminosarum

5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism

Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

Plant peroxidases: substrate complexes with mechanistic implications

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