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Keywords: X-ray crystallography
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Articles
Biochem Soc Trans (2016) 44 (4): 1177–1182.
Published: 15 August 2016
... eukaryotic RNA polymerase complex integrated structural biology multiprotein assembly X-ray crystallography Our laboratory studies the mechanisms of gene transcription and its regulation in eukaryotic cells with a combination of in vitro and in vivo approaches. We use integrated structural...
Articles
Biochem Soc Trans (2013) 41 (5): 1260–1264.
Published: 23 September 2013
... correspondence should be addressed (email a.r.pearson@leeds.ac.uk ). 26 6 2013 © 2013 The Authors 2013 laser spectroscopy synchrotron time-resolved spectroscopy X-ray crystallography To fully understand a biochemical process, it is necessary to observe not only the resting state...
Articles
Biochem Soc Trans (2013) 41 (5): 1265–1271.
Published: 23 September 2013
... conditions tested, ~1000 crystals frozen and tested at the synchrotrons, and ~80 datasets collected. bioenergetics complex I membrane protein structure NADH:ubiquinone oxidoreductase respiratory chain X-ray crystallography Complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) plays...
Articles
Biochem Soc Trans (2013) 41 (4): 1008–1016.
Published: 18 July 2013
... correspondence should be addressed (email jane.endicott@ncl.ac.uk ). 3 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cell cycle cyclin cyclin-dependent kinase (CDK) phosphorylation transcription X-ray crystallography It was Louise Johnson who first drew...
Articles
Biochem Soc Trans (2012) 40 (3): 531–538.
Published: 22 May 2012
... can be monitored by combining X-ray crystallography, in crystallo optical spectroscopy and simulation tools such as quantum chemistry/molecular mechanics hybrid approaches. Besides their usefulness to rationally engineer better performing fluorescent proteins for nanoscopy and other biotechnological...
Articles
Biochem Soc Trans (2012) 40 (2): 351–356.
Published: 21 March 2012
... enzymes and factors. 1 email sxt30@psu.edu 6 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 chromatin histone acetyltransferase (HAT) molecular recognition nucleosome X-ray crystallography If DNA is the blueprint of life, there must...
Articles
Biochem Soc Trans (2011) 39 (5): 1313–1322.
Published: 21 September 2011
... that these contacts will continue to expand in the future. 1 email ggd@ysbl.york.ac.uk 23 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Chinese biochemistry Chinese–U.K. research collaboration insulin U.K. biochemistry X-ray crystallography Figure 10...
Articles
Biochem Soc Trans (2011) 39 (5): 1323–1326.
Published: 21 September 2011
... biochemistry Chinese–U.K. research collaboration insulin U.K. biochemistry X-ray crystallography On the occasion of the Centenary of the founding of Biochemical Society, the Joint Sino–U.K. Protein Symposium was held in Shanghai in May 2011. In the present article, I focus on insulin research...
Articles
Biochem Soc Trans (2011) 39 (3): 775–779.
Published: 20 May 2011
... pleasure therefore to dedicate this short contribution to him on the occasion of his retirement. This study has shown the usefulness of heavy-atom-tagged phospholipids and detergents in combination with X-ray crystallography to explore surface binding sites for these molecules around membrane proteins...
Articles
Biochem Soc Trans (2009) 37 (2): 378–381.
Published: 20 March 2009
...Arwen R. Pearson; Robin L. Owen The combination of X-ray crystallography and rapid cryo-trapping methods has enabled the visualization of catalytic intermediates in a variety of enzyme systems. However, the resolution of the X-ray experiment is not always sufficient to precisely place the structure...
Articles
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography MX (macromolecular X-ray crystallography) is the most popular method to obtain high-resolution structural information on protein–protein complexes, and it yields the most...
Articles
Biochem Soc Trans (2008) 36 (6): 1175–1179.
Published: 19 November 2008
... salient difference between the haem pockets is that a valine residue in cytochrome c 6A replaces a highly conserved glutamine residue in cytochrome c 6 . This difference has been probed using site-directed mutagenesis, X-ray crystallography and protein film voltammetry studies. It has been found...
Articles
Biochem Soc Trans (2008) 36 (5): 996–1000.
Published: 19 September 2008
... reductase membrane protein succinate dehydrogenase transmembrane electrochemical proton potential X-ray crystallography According to Peter Mitchell's chemiosmotic theory [ 1 ], the energy released upon the oxidation of electron donor substrates in both aerobic and anaerobic respiration...
Articles
Biochem Soc Trans (2008) 36 (4): 567–574.
Published: 22 July 2008
... codon–anticodon pairing decoding ribosome RNA X-ray crystallography Ribosomes are large macromolecular assemblies consisting of approx. two-thirds by mass of RNA, with the rest being proteins. Given their molecular mass of approx. 2.5 MDa in bacteria, it was not clear whether it would ever...
Articles
Biochem Soc Trans (2008) 36 (2): 181–187.
Published: 20 March 2008
... cadherin molecules interacting at their N-terminal tips. An integrative structural approach involving X-ray crystallography, cryo-electron tomography and immuno-electron microscopy should give the complete picture of the architecture of this important junction; identifying its various proteins and showing...
Articles
Biochem Soc Trans (2008) 36 (1): 27–32.
Published: 22 January 2008
... simulation coarse-grained simulation high-throughput computational approach membrane protein Molecular Dynamics X-ray crystallography Membrane proteins are of considerable biomedical importance, accounting for approx. 25% of genes [ 1 ] and forming a major class of drug targets. Although...
Articles
Biochem Soc Trans (2006) 34 (6): 1058–1061.
Published: 25 October 2006
... in the Pol III modelling because of weak or apparently lacking sequence conservation with its Pol III counterpart C17/25. We therefore determined the C17/25 structure by X-ray crystallography. The structure of C25 resembles that of its counterparts Rpb7 and RpoE. The structure of C17 reveals a compact N...
Articles
Biochem Soc Trans (2005) 33 (5): 924–930.
Published: 26 October 2005
... the membrane lipids. X-ray crystallography has provided high-resolution structures for PS-I and the purple bacterial reaction centre, and revealed binding sites for a number of lipids, either embedded in the protein interior or attached to the protein surface. These lipids play a variety of roles, including...
Articles
Biochem Soc Trans (2004) 32 (5): 761–763.
Published: 26 October 2004
...@spring8.or.jp 5 7 2004 © 2004 The Biochemical Society 2004 Brownian motion diffracted X-ray tracking (DXT) single proton molecular dynamics X-ray crystallography We could not detect the displacement (Δ2θ≈400 mrad/36 ms) of the observed diffraction spots because of the size...
Articles
Biochem Soc Trans (2004) 32 (5): 647–654.
Published: 26 October 2004
... site. These changes result in repositioning of the key residues (threonine, lysine and tyrosine) within the active site. 29 6 2004 © 2004 The Biochemical Society 2004 deoxy sugar NADH rhamnose X-ray crystallography Carbohydrates remain a challenge for the synthetic...
Articles
Biochem Soc Trans (2003) 31 (5): 973–979.
Published: 01 October 2003
...R.A. Palmer; H. Niwa X-ray crystallography enables details of covalent and non-covalent interactions to be analysed quantitatively in three dimensions, thus providing the basis for the understanding of binding of ligands to proteins as well as modes of action such as cell-surface binding...
Articles
Biochem Soc Trans (2003) 31 (4): 791–794.
Published: 01 August 2003
... ligands. They also lack any apparent enzymic activity. Concurrent with the rapid increase in available genomic sequence data in recent years, it has become apparent that the LTP/LPS-binding proteins are part of a much larger family Key words: BPI, homology modelling, X-ray crystallography. Abbreviations...
Articles
Biochem Soc Trans (2003) 31 (3): 532–536.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 19 February 2003 © 2003 Biochemical Society 2003 enzyme structure sugar X-ray crystallography Abbreviation used: LBHB, low-barrier hydrogen bond. 532 Biochemical Society Transactions...
Articles
Biochem Soc Trans (2003) 31 (3): 634–636.
Published: 01 June 2003
... Focused Meeting held at AstraZeneca R&D Charnwood, Loughborough, 24–25 February 2003 11 February 2003 © 2003 Biochemical Society 2003 computational docking study conotoxin molecular topology X-ray crystallography Abbreviations used: ACh, acetylcholine; nAChR...
Articles
Biochem Soc Trans (2003) 31 (3): 493–496.
Published: 01 June 2003
... plasma. Recently the CuAO located in adipocyte membranes has been linked to glucose transport via the GLUT-4 pathway [5 10]. Key words: catalytic intermediate, copper-containing amine oxidase, oxygen activation, quinoprotein, X-ray crystallography. Abbreviations used: CuAO, copper-containing amine...
Articles
Biochem Soc Trans (2003) 31 (3): 563–571.
Published: 01 June 2003
... University, 12–14 January 2003 16 December 2002 © 2003 Biochemical Society 2003 enzyme pathway evolution pantothenate X-ray crystallography Abbreviations used: KPHMT, ketopantoate hydroxymethyltransferase; KPR, ketopantoate reductase; ADC, aspartate decarboxylase; PS...
Articles
Biochem Soc Trans (2003) 31 (3): 620–624.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at AstraZeneca R&D Charnwood, Loughborough, 24–25 February 2003 23 January 2003 © 2003 Biochemical Society 2003 cholesterol metabolism cocaine heroin human carboxylesterase 1 inhibitor X-ray crystallography Abbreviations used...
Articles
Biochem Soc Trans (2003) 31 (3): 553–557.
Published: 01 June 2003
... is activated up to 200-fold by the binding of NO to the haem, whereas the binding of CO gives rise to only a mild stimulation of activity. Through X-ray crystallography we have studied NO and CO binding to cyt c ´. CO binds to the distal face to give a 6-coordinate (6c) adduct. By contrast, NO binding gives...
Articles
Biochem Soc Trans (2003) 31 (3): 528–531.
Published: 01 June 2003
... December 2002 © 2003 Biochemical Society 2003 atherosclerosis cholesterol-lowering enzyme inhibition isothermal titration calorimetry statin X-ray crystallography Abbreviations used: E.I, enzyme–inhibitor complex; E.I*, second E.I complex in a two-step mechanism; HMG-CoA, 3...
Articles
Biochem Soc Trans (2003) 31 (3): 506–509.
Published: 01 June 2003
... – A Structural Perspective, a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 6 January 2003 © 2003 Biochemical Society 2003 cofactor biogenesis copper galactose oxidase post-translational processing X-ray crystallography Abbreviations...
Articles
Biochem Soc Trans (2002) 30 (6): 990–996.
Published: 01 November 2002
... Paul.Barlowa@ac.uk ) 18 6 2002 © 2002 Biochemical Society 2002 complement module multiple domain NMR X-ray crystallography CCP, complement control protein module CR, complement receptor: HSQC, heteronuclear single-quantum coherence: LHR, long homologous repeat: MCP, membrane...
Articles
Biochem Soc Trans (2002) 30 (6): 1162–1166.
Published: 01 November 2002
... through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein...
Articles
Biochem Soc Trans (2002) 30 (4): 584–590.
Published: 01 August 2002
... in the recovery of substantial enzyme activity. The effects of the site-directed alkylating inhibitor, 5-chlorolaevulinic acid, and 4,7-dioxosebacic acid, a putative intermediate analogue, were investigated by X-ray crystallography. These inhibitors reacted with both active-site lysine residues. The role...
Articles
Biochem Soc Trans (2002) 30 (4): 771–774.
Published: 01 August 2002
... a.hemmings@uea.ac.uk ) 5 4 2002 © 2002 Biochemical Society 2002 apo-Fur solution X-ray scattering X-ray crystallography Fur, ferric-uptake regulatory protein HTH, helix-tum-helix Biometals 2002: Third International Biometals Symposium: Focused Meeting Organized by S...
Articles
Biochem Soc Trans (2001) 29 (4): 377–384.
Published: 01 August 2001
... correspondence should be addressed (e-mail mlemmon@mail.med.upenn.edu ) 16 3 2001 © 2001 Biochemical Society 2001 PH domains phosphoinositide-binding sites phosphoinositide 3-kinase X-ray crystallography Btk, Bruton's tyrosine kinase DAPPI, d ual a daptor for p hosphotyrosine...
Articles
Biochem Soc Trans (2001) 29 (2): 91–99.
Published: 01 May 2001
... evidence. 1 E-mail gajhede@psg.ki.ku.dk 21 12 2000 © 2001 Biochemical Society 2001 structure X-ray crystallography BHA, benzhydroxamic acid HRP C, horseradish peroxidase C FA, ferulic acid CCP, cytochrome c peroxidase ARP, Arthromyces ramosus peroxidase n 0...