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Keywords: X-ray crystallography
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Articles
Biochem Soc Trans (2016) 44 (4): 1177–1182.
Published: 15 August 2016
... Press Limited on behalf of the Biochemical Society 2016 cryo-electron microscopy eukaryotic RNA polymerase complex integrated structural biology multiprotein assembly X-ray crystallography Our laboratory studies the mechanisms of gene transcription and its regulation in eukaryotic...
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Articles
Biochem Soc Trans (2013) 41 (5): 1265–1271.
Published: 23 September 2013
... © 2013 The Authors 2013 bioenergetics complex I membrane protein structure NADH:ubiquinone oxidoreductase respiratory chain X-ray crystallography Complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) plays a central role in the respiratory chain in mitochondria and many bacteria...
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Biochem Soc Trans (2013) 41 (4): 1008–1016.
Published: 18 July 2013
... and regulation. 3 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cell cycle cyclin cyclin-dependent kinase (CDK) phosphorylation transcription X-ray crystallography 1 To whom correspondence should be addressed (email jane.endicott@ncl.ac.uk...
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Biochem Soc Trans (2012) 40 (3): 531–538.
Published: 22 May 2012
... can be monitored by combining X-ray crystallography, in crystallo optical spectroscopy and simulation tools such as quantum chemistry/molecular mechanics hybrid approaches. Besides their usefulness to rationally engineer better performing fluorescent proteins for nanoscopy and other biotechnological...
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Articles
Biochem Soc Trans (2011) 39 (5): 1323–1326.
Published: 21 September 2011
... biochemistry Chinese–U.K. research collaboration insulin U.K. biochemistry X-ray crystallography On the occasion of the Centenary of the founding of Biochemical Society, the Joint Sino–U.K. Protein Symposium was held in Shanghai in May 2011. In the present article, I focus on insulin research...
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Biochem Soc Trans (2011) 39 (5): 1313–1322.
Published: 21 September 2011
... that these contacts will continue to expand in the future. 1 email ggd@ysbl.york.ac.uk 23 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Chinese biochemistry Chinese–U.K. research collaboration insulin U.K. biochemistry X-ray crystallography Figure 1...
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Biochem Soc Trans (2011) 39 (3): 775–779.
Published: 20 May 2011
... X-ray crystallography Our previous site-directed mutagenesis study on the relationship between the structure and function of the Rhodobacter sphaeroides RC (reaction centre) determined the X-ray crystal structure of many such mutants [ 1 ]. Careful analysis of these structures revealed two...
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Articles
Biochem Soc Trans (2008) 36 (6): 1175–1179.
Published: 19 November 2008
... salient difference between the haem pockets is that a valine residue in cytochrome c 6A replaces a highly conserved glutamine residue in cytochrome c 6 . This difference has been probed using site-directed mutagenesis, X-ray crystallography and protein film voltammetry studies. It has been found...
Articles
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... structures solved by different groups, before concluding in the ‘Outlook’ section. © The Authors Journal compilation © 2008 Biochemical Society 2008 acyl-CoA thioesterase 7 (Acot7) platelet glycoprotein Ibα protein–protein interaction structural biology thrombin X-ray crystallography...
Articles
Biochem Soc Trans (2008) 36 (5): 996–1000.
Published: 19 September 2008
... reductase membrane protein succinate dehydrogenase transmembrane electrochemical proton potential X-ray crystallography According to Peter Mitchell's chemiosmotic theory [ 1 ], the energy released upon the oxidation of electron donor substrates in both aerobic and anaerobic respiration...
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Biochem Soc Trans (2008) 36 (4): 567–574.
Published: 22 July 2008
... codon–anticodon pairing decoding ribosome RNA X-ray crystallography Ribosomes are large macromolecular assemblies consisting of approx. two-thirds by mass of RNA, with the rest being proteins. Given their molecular mass of approx. 2.5 MDa in bacteria, it was not clear whether it would ever...
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Biochem Soc Trans (2008) 36 (2): 181–187.
Published: 20 March 2008
... cadherin molecules interacting at their N-terminal tips. An integrative structural approach involving X-ray crystallography, cryo-electron tomography and immuno-electron microscopy should give the complete picture of the architecture of this important junction; identifying its various proteins and showing...
Articles
Biochem Soc Trans (2008) 36 (1): 27–32.
Published: 22 January 2008
... simulation coarse-grained simulation high-throughput computational approach membrane protein Molecular Dynamics X-ray crystallography Membrane proteins are of considerable biomedical importance, accounting for approx. 25% of genes [ 1 ] and forming a major class of drug targets. Although...
Articles
Biochem Soc Trans (2006) 34 (6): 1058–1061.
Published: 25 October 2006
... in the Pol III modelling because of weak or apparently lacking sequence conservation with its Pol III counterpart C17/25. We therefore determined the C17/25 structure by X-ray crystallography. The structure of C25 resembles that of its counterparts Rpb7 and RpoE. The structure of C17 reveals a compact N...
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Biochem Soc Trans (2005) 33 (5): 924–930.
Published: 26 October 2005
... the membrane lipids. X-ray crystallography has provided high-resolution structures for PS-I and the purple bacterial reaction centre, and revealed binding sites for a number of lipids, either embedded in the protein interior or attached to the protein surface. These lipids play a variety of roles, including...
Articles
Biochem Soc Trans (2004) 32 (5): 647–654.
Published: 26 October 2004
... a value approx. 16) would greatly accelerate the mechanism. We have suggested that the threonine residue fine-tunes the p K a of the substrate transition state to achieve an optimal match with tyrosine. © 2004 The Biochemical Society 2004 deoxy sugar NADH rhamnose X-ray crystallography...
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Biochem Soc Trans (2004) 32 (5): 761–763.
Published: 26 October 2004
...@spring8.or.jp 5 7 2004 © 2004 The Biochemical Society 2004 Brownian motion diffracted X-ray tracking (DXT) single proton molecular dynamics X-ray crystallography All X-ray techniques are based on the averaged measurements of many molecules or atoms. Thus the behaviours...
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Biochem Soc Trans (2003) 31 (5): 973–979.
Published: 01 October 2003
...R.A. Palmer; H. Niwa X-ray crystallography enables details of covalent and non-covalent interactions to be analysed quantitatively in three dimensions, thus providing the basis for the understanding of binding of ligands to proteins as well as modes of action such as cell-surface binding...
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Biochem Soc Trans (2003) 31 (4): 791–794.
Published: 01 August 2003
... ligands. They also lack any apparent enzymic activity. Concurrent with the rapid increase in available genomic sequence data in recent years, it has become apparent that the LTP/LPS-binding proteins are part of a much larger family Key words: BPI, homology modelling, X-ray crystallography. Abbreviations...
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Biochem Soc Trans (2003) 31 (3): 553–557.
Published: 01 June 2003
... is activated up to 200-fold by the binding of NO to the haem, whereas the binding of CO gives rise to only a mild stimulation of activity. Through X-ray crystallography we have studied NO and CO binding to cyt c ´. CO binds to the distal face to give a 6-coordinate (6c) adduct. By contrast, NO binding gives...
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Biochem Soc Trans (2003) 31 (3): 528–531.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 18 December 2002 © 2003 Biochemical Society 2003 atherosclerosis cholesterol-lowering enzyme inhibition isothermal titration calorimetry statin X-ray crystallography Abbreviations used...
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Biochem Soc Trans (2003) 31 (3): 506–509.
Published: 01 June 2003
... – A Structural Perspective, a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 6 January 2003 © 2003 Biochemical Society 2003 cofactor biogenesis copper galactose oxidase post-translational processing X-ray crystallography Abbreviations...
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Biochem Soc Trans (2003) 31 (3): 532–536.
Published: 01 June 2003
... University, 12–14 January 2003 19 February 2003 © 2003 Biochemical Society 2003 enzyme structure sugar X-ray crystallography Abbreviation used: LBHB, low-barrier hydrogen bond. 532 Biochemical Society Transactions (2003) Volume 31, part 3 A structural perspective...
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Biochem Soc Trans (2003) 31 (3): 634–636.
Published: 01 June 2003
... Focused Meeting held at AstraZeneca R&D Charnwood, Loughborough, 24–25 February 2003 11 February 2003 © 2003 Biochemical Society 2003 computational docking study conotoxin molecular topology X-ray crystallography Abbreviations used: ACh, acetylcholine; nAChR...
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Biochem Soc Trans (2003) 31 (3): 493–496.
Published: 01 June 2003
... plasma. Recently the CuAO located in adipocyte membranes has been linked to glucose transport via the GLUT-4 pathway [5 10]. Key words: catalytic intermediate, copper-containing amine oxidase, oxygen activation, quinoprotein, X-ray crystallography. Abbreviations used: CuAO, copper-containing amine...
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Biochem Soc Trans (2003) 31 (3): 563–571.
Published: 01 June 2003
... University, 12–14 January 2003 16 December 2002 © 2003 Biochemical Society 2003 enzyme pathway evolution pantothenate X-ray crystallography Abbreviations used: KPHMT, ketopantoate hydroxymethyltransferase; KPR, ketopantoate reductase; ADC, aspartate decarboxylase; PS...
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Biochem Soc Trans (2003) 31 (3): 620–624.
Published: 01 June 2003
..., a Biochemical Society Focused Meeting held at AstraZeneca R&D Charnwood, Loughborough, 24–25 February 2003 23 January 2003 © 2003 Biochemical Society 2003 cholesterol metabolism cocaine heroin human carboxylesterase 1 inhibitor X-ray crystallography Abbreviations used...
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Biochem Soc Trans (2002) 30 (6): 990–996.
Published: 01 November 2002
...-mail Paul.Barlowa@ac.uk ) 18 6 2002 © 2002 Biochemical Society 2002 complement module multiple domain NMR X-ray crystallography CCP, complement control protein module CR, complement receptor: HSQC, heteronuclear single-quantum coherence: LHR, long homologous repeat: MCP, membrane...
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Biochem Soc Trans (2002) 30 (6): 1162–1166.
Published: 01 November 2002
... through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein...
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Biochem Soc Trans (2002) 30 (4): 771–774.
Published: 01 August 2002
...-mail a.hemmings@uea.ac.uk ) 5 4 2002 © 2002 Biochemical Society 2002 apo-Fur solution X-ray scattering X-ray crystallography Fur, ferric-uptake regulatory protein HTH, helix-tum-helix Biometals 2002: Third International Biometals Symposium: Focused Meeting Organized by S...
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Biochem Soc Trans (2002) 30 (4): 584–590.
Published: 01 August 2002
... in the recovery of substantial enzyme activity. The effects of the site-directed alkylating inhibitor, 5-chlorolaevulinic acid, and 4,7-dioxosebacic acid, a putative intermediate analogue, were investigated by X-ray crystallography. These inhibitors reacted with both active-site lysine residues. The role...
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Biochem Soc Trans (2001) 29 (4): 377–384.
Published: 01 August 2001
... correspondence should be addressed (e-mail mlemmon@mail.med.upenn.edu ) 16 3 2001 © 2001 Biochemical Society 2001 PH domains phosphoinositide-binding sites phosphoinositide 3-kinase X-ray crystallography Btk, Bruton's tyrosine kinase DAPPI, d ual a daptor for p hosphotyrosine...
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Biochem Soc Trans (2001) 29 (2): 91–99.
Published: 01 May 2001
... evidence. 1 E-mail gajhede@psg.ki.ku.dk 21 12 2000 © 2001 Biochemical Society 2001 structure X-ray crystallography BHA, benzhydroxamic acid HRP C, horseradish peroxidase C FA, ferulic acid CCP, cytochrome c peroxidase ARP, Arthromyces ramosus peroxidase n 0...