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Keywords: Wnt signalling
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Biochem Soc Trans (2019) 47 (1): 197–207.
Published: 21 December 2018
... displays intrinsic GTPase activity and functions as a signalling scaffold. As an example, LRRK2 was suggested to be part of the NRON complex and β-catenin destruction complex, inhibiting NFAT and canonical Wnt signalling, respectively. In summary, continuous research into LRRK2 signalling function...
Biochem Soc Trans (2012) 40 (5): 1123–1128.
Published: 19 September 2012
... signalling pathways for the healthy functioning of the adult brain and the dysregulation of these pathways in neurodegenerative disease has become apparent. Cell biological functions disrupted in PD are partially controlled by Wnt signalling pathways and proteins encoded by PARK genes have been shown...
Biochem Soc Trans (2011) 39 (6): 1725–1728.
Published: 21 November 2011
... and cytoskeletal activities. α-catenin chromatin laminopathy linker of nucleoskeleton and cytoskeleton complex (LINC complex) nesprin Wnt signalling wound healing The nature of the NE (nuclear envelope) is of fundamental interest in cell biology as it forms an interface between the nuclear...
Biochem Soc Trans (2005) 33 (4): 672–675.
Published: 01 August 2005
... (adenomatous polyposis coli) genes occur early in the development of CRC and lead to the stabilization of the Wnt pathway component β-catenin and to the constitutive activation of Wnt signalling. Stabilizing mutations of β-catenin can also lead to its accumulation, qualifying β-catenin as a proto-oncogene...
Biochem Soc Trans (2004) 32 (5): 792–796.
Published: 26 October 2004
...H. Wang; Y. Lee; C.C. Malbon Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca 2+ /cGMP pathway mediated by Frizzled-2 was discovered recently. Activation...