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Keywords: Wnt proteins
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Biochem Soc Trans (2022) 50 (6): 1763–1772.
Published: 23 November 2022
... Mancia ( fm123@cumc.columbia.edu ) 20 9 2022 3 11 2022 7 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cryo-EM membrane proteins palmitoleation WLS Wnt proteins Wnts are short-range signaling proteins...
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
...) receptors, and R-spondins (RSPOs), which bind to LGR family receptors. Wnt proteins are lipid-modified at a conserved serine by the O -acyltransferase Porcupine to facilitate secretion and receptor binding. Canonical Wnt signalling can be amplified following concomitant binding of Wnt and R-spondin (RSPO...
Biochem Soc Trans (2018) 46 (3): 761–771.
Published: 05 June 2018
... 4 2018 © 2018 The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer casein kinase CK1 FAM83 PLD Wnt proteins...
Biochem Soc Trans (2017) 45 (2): 409–416.
Published: 13 April 2017
... inhibitors have recently been developed that target hedgehog acyltransferase (Hhat) and Porcupine (Porcn), the acyltransferases that modify hedgehog and Wnt proteins, respectively. These inhibitors, coupled with targeted knockdown of Hhat and Porcn, reveal the essential functions of fatty acylation...
Biochem Soc Trans (2016) 44 (6): 1745–1751.
Published: 02 December 2016
... cilia polycystic kidney disease Wnt proteins The cilium is an evolutionarily conserved, microtubule-based organelle, the existence of which was discovered >200 years ago. Although it contains similarities with the prokaryotic flagellum, its role and functional importance was unclear until...
Biochem Soc Trans (2016) 44 (6): 1625–1634.
Published: 02 December 2016
... disease Wnt proteins Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and is characterised by resting tremor, akinesia, bradykinesia, and postural instability, although additional non-motor symptoms are common. Parkinsonian symptoms coincide with the death...