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Keywords: Wnt
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Articles
Biochem Soc Trans (2020) 48 (3): 1187–1198.
Published: 15 May 2020
...Pablo Astudillo The Wnt/β-catenin signaling pathway plays fundamental roles during development, stem cell differentiation, and homeostasis, and its abnormal activation can lead to diseases. In recent years, it has become clear that this pathway integrates signals not only from Wnt ligands but also...
Articles
Biochem Soc Trans (2015) 43 (2): 211–216.
Published: 07 April 2015
...Claudia Y. Janda; K. Christopher Garcia Wnt proteins are conserved signalling molecules that have an essential role in regulating diverse processes during embryogenesis and adult tissue homoeostasis. Wnts are post-translationally modified by palmitoylation, which is essential for Wnt secretion...
Articles
Biochem Soc Trans (2015) 43 (2): 235–239.
Published: 07 April 2015
..., the Wnt, Hedgehog (Hh) and Ghrelin proteins. Given their important roles in adult tissue homoeostasis, all three molecules and their respective associated acyltransferases provide a framework for interrogating the role of extracellular acylation events in cell-to-cell communication. Here, we discuss how...
Articles
Biochem Soc Trans (2010) 38 (5): 1281–1285.
Published: 24 September 2010
...Bente Kofahl; Jana Wolf The Wnt/β-catenin pathway plays an important role in development and disease. Theoretical approaches have been used to describe this pathway and have provided intriguing insights into its signalling characteristics. In the present paper, we review mathematical models...
Articles
Biochem Soc Trans (2009) 37 (5): 1133–1138.
Published: 21 September 2009
... antagonizes Wnt signalling by constitutively phosphorylating β-catenin and promoting its degradation [ 12 ]. Thus inhibition of GSK3 by lithium will activate these pathways downstream of GSK3. This downstream activation can explain many of the known effects of lithium on glycogen synthesis, development...