... the mitochondria in cancer cells to be functional across a range of tumour types. However, different tumour populations have different bioenergetic alterations in order to meet their high energy requirement; the Warburg effect is not consistent across all cancer types. This review will discuss the metabolic...

.... This is known as the Warburg effect (named after German biochemist Otto H. Warburg) and also applies to striated muscle cells, activated lymphocytes, microglia, endothelial cells and several other cell types. For similar phenomena in several yeasts and many bacteria, the terms Crabtree effect and overflow...

... effect, postulated in 1929, has languished in the shadow of the Warburg effect in terms of research attention [ 4 ]. The Crabtree effect is simply defined as the observation that high concentrations of glucose result in a decrease in mitochondrial respiration in cancer cells [ 4 ]. The role of inhibited...

... of metabolically derived inputs into the signalling system and the regulation of transcription. I also discuss the Warburg effect where the cross-talk between metabolism and signalling is used to orchestrate rapid cell growth and division. It is becoming clear that future research will concentrate...