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Keywords: UPR
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Biochem Soc Trans (2024) 52 (2): 581–592.
Published: 15 March 2024
... autophagy ISR neurons nutrient stress proteome UPR Despite only weighing 2% of the body, the brain requires ∼20% of the body's total energy expenditure [ 1 ]. The brain heavily relies on glucose as its primary energy source. A prolonged drop in glucose supply can cause autonomic failure...
Biochem Soc Trans (2021) 49 (3): 1251–1263.
Published: 18 May 2021
... to radiobiological hypoxia is one of few physiologically relevant stresses that activates both the unfolded protein and DNA damage responses (UPR and DDR). Links between these pathways have been identified in studies carried out in normoxia. Based in part on these previous studies and recent work from our laboratory...
Includes: Supplementary data
Biochem Soc Trans (2020) 48 (1): 199–205.
Published: 17 February 2020
... 2020 endoplasmic reticulum LTK proteostasis tyrosine kinase UPR Tyrosine kinases catalyze a very frequently occurring phosphorylation event that is essential for multicellular organisms. The absence of tyrosine kinases in many unicellular organisms led to the view...