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Keywords: Type 2 diabetes mellitus (T2DM)
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Articles

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

Christian Hölscher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 891–897.
https://doi.org/10.1042/BST0390891
Published: 20 July 2011
... ]. This clearly limits the application of BDNF as a treatment for AD. Alzheimer's disease (AD) central nervous system (CNS) glucagon-like peptide-1 (GLP1) insulin receptor substrate (IRS) Type 2 diabetes mellitus (T2DM) AD (Alzheimer's disease) is a progressive neurodegenerative disease for which...
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Articles

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells

Merewyn K. Loder, Gabriela da Silva Xavier, Angela McDonald, Guy A. Rutter
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 357–359.
https://doi.org/10.1042/BST0360357
Published: 21 May 2008
... and insulin gene expression while slightly potentiating glucose stimulated changes in intracellular free Ca 2+ concentrations. β-cell diabetes forkhead box O1 (FoxO1) insulin secretion T-cell factor 7-like 2 (TCF7L2) Type 2 diabetes mellitus (T2DM) 1 These authors contributed equally...
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