... dehydrogenase (GAPDH) Plasmodium falciparum Trichomonas vaginalis Trypanosoma brucei A classic association of reductive evolution with the adaptation to obligate parasitism is evident to a greater or lesser degree in all parasitic protists studied to date. For instance, the loss of common...

...Eva Gluenz; Amy R. Barker; Keith Gull Trypanosomatids are protozoan parasites that cause human and animal disease. Trypanosoma brucei telomeric ESs (expression sites) contain genes that are critical for parasite survival in the bloodstream, including the VSG (variant surface glycoprotein) genes...

... To whom correspondence should be addressed (email b.m.bakker@med.umcg.nl ). 16 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 kinetic model of metabolism Saccharomyces cerevisiae Silicon Cell skeletal muscle Trypanosoma brucei Recently...

... mechanics of cytokinesis is however probably no better illustrated than in the protozoa. A dramatic example of this is the protozoan parasite Trypanosoma brucei , a unicellular flagellated parasite that causes a devastating disease (African sleeping sickness) across Sub-Saharan Africa in both man...

...W. Gibson; L. Peacock; V. Ferris; K. Williams; M. Bailey Trypanosoma brucei undergoes genetic exchange in its insect vector, but the mechanism is unknown and no one has yet seen the process. By crossing genetically engineered red and green fluorescent trypanosomes, we have been able to pinpoint...

... replication RNA interference (RNAi) Trypanosoma brucei trypanosome More recently, we have used the library to discover new genes for kDNA replication proteins. Since we had previously found that RNAi of several replication enzymes resulted in shrinking and loss of the network (see e.g. [ 12...

...G. Rudenko The African trypanosome Trypanosoma brucei has a precarious existence as an extracellular parasite of the mammalian bloodstream, where it is faced with continuous immune attack. Key to survival is a dense VSG (variant surface glycoprotein) coat, which is repeatedly switched during...

... -inositol can then be incorporated into PI (phosphatidylinositol), which is utilized in a variety of cellular functions, including the biosynthesis of GPI (glycosylphosphatidylinositol) anchors. A putative INO1 was identified in the Trypanosoma brucei genome database and, by recombinant expression...

... features, such as their specially adapted mitochondrion and the compartmentalization of glycolytic enzymes in glycosomes. The energy metabolism of Trypanosoma brucei differs significantly from that of their hosts and changes drastically during the life cycle. Despite the presence of all citric acid cycle...

...H.P. Price; D. Goulding; D.F. Smith Myristoyl-CoA protein:NMT (N-myristoyl transferase) catalyses the N-myristoylation of cellular proteins with a range of functions and is essential for viability in the protozoan parasites, Leishmania major and Trypanosoma brucei . In our investigations to define...

... structures have been implicated in glycoprotein folding or ER quality control. Components of the system appear across a range of organisms; however, the precise combination differs between organisms. We have identified putative components of the system in the protozoal organism Trypanosoma brucei by local...

...-mail athel@ibsm.cnrs-mrs.fr ). 19 11 2001 © 2002 Biochemical Society 2002 computer analysis of metabolism metabolic modelling pathway analysis Trypanosoma brucei Metabolite Channelling and Metabolic Complexity 35 36 37 38 Cascante, M., Centelles, J. j. and Agius, L. (2000) Biochern...