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Keywords: Trypanosoma brucei
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Articles
Biochem Soc Trans (2014) 42 (6): 1734–1739.
Published: 17 November 2014
... glycolytic enzymes within peroxisomes and organization of the mitochondrial genome into an elaborate disk-like array of several thousand circular DNA molecules linked by catenation and known as the kinetoplast [ 41 , 42 ]. In the African trypanosome Trypanosoma brucei , the trypanosomatid in which metabolic...
Articles
Biochem Soc Trans (2011) 39 (4): 966–970.
Published: 20 July 2011
...Eva Gluenz; Amy R. Barker; Keith Gull Trypanosomatids are protozoan parasites that cause human and animal disease. Trypanosoma brucei telomeric ESs (expression sites) contain genes that are critical for parasite survival in the bloodstream, including the VSG (variant surface glycoprotein) genes...
Articles
Biochem Soc Trans (2010) 38 (5): 1294–1301.
Published: 24 September 2010
... model of metabolism Saccharomyces cerevisiae Silicon Cell skeletal muscle Trypanosoma brucei Recently there has been a growing interest in applying systems biology approaches and, to a lesser extent, kinetic modelling to understand human metabolic diseases [ 1 – 3 ]. Clearly, progress...
Articles
Biochem Soc Trans (2008) 36 (3): 421–424.
Published: 21 May 2008
... mechanics of cytokinesis is however probably no better illustrated than in the protozoa. A dramatic example of this is the protozoan parasite Trypanosoma brucei , a unicellular flagellated parasite that causes a devastating disease (African sleeping sickness) across Sub-Saharan Africa in both man...
Articles
Biochem Soc Trans (2006) 34 (4): 557–559.
Published: 21 July 2006
...W. Gibson; L. Peacock; V. Ferris; K. Williams; M. Bailey Trypanosoma brucei undergoes genetic exchange in its insect vector, but the mechanism is unknown and no one has yet seen the process. By crossing genetically engineered red and green fluorescent trypanosomes, we have been able to pinpoint...
Articles
Biochem Soc Trans (2005) 33 (6): 1409–1412.
Published: 26 October 2005
... replication RNA interference (RNAi) Trypanosoma brucei trypanosome More recently, we have used the library to discover new genes for kDNA replication proteins. Since we had previously found that RNAi of several replication enzymes resulted in shrinking and loss of the network (see e.g. [ 12...
Articles
Biochem Soc Trans (2005) 33 (5): 981–982.
Published: 26 October 2005
...G. Rudenko The African trypanosome Trypanosoma brucei has a precarious existence as an extracellular parasite of the mammalian bloodstream, where it is faced with continuous immune attack. Key to survival is a dense VSG (variant surface glycoprotein) coat, which is repeatedly switched during...
Articles
Biochem Soc Trans (2005) 33 (5): 967–971.
Published: 26 October 2005
... features, such as their specially adapted mitochondrion and the compartmentalization of glycolytic enzymes in glycosomes. The energy metabolism of Trypanosoma brucei differs significantly from that of their hosts and changes drastically during the life cycle. Despite the presence of all citric acid cycle...
Articles
Biochem Soc Trans (2005) 33 (5): 983–985.
Published: 26 October 2005
... -inositol can then be incorporated into PI (phosphatidylinositol), which is utilized in a variety of cellular functions, including the biosynthesis of GPI (glycosylphosphatidylinositol) anchors. A putative INO1 was identified in the Trypanosoma brucei genome database and, by recombinant expression...
Articles
Biochem Soc Trans (2005) 33 (4): 643–645.
Published: 01 August 2005
...H.P. Price; D. Goulding; D.F. Smith Myristoyl-CoA protein:NMT (N-myristoyl transferase) catalyses the N-myristoylation of cellular proteins with a range of functions and is essential for viability in the protozoan parasites, Leishmania major and Trypanosoma brucei . In our investigations to define...
Articles
Biochem Soc Trans (2004) 32 (5): 766–768.
Published: 26 October 2004
... structures have been implicated in glycoprotein folding or ER quality control. Components of the system appear across a range of organisms; however, the precise combination differs between organisms. We have identified putative components of the system in the protozoal organism Trypanosoma brucei by local...
Articles
Biochem Soc Trans (2002) 30 (2): 43–46.
Published: 01 April 2002
...-mail athel@ibsm.cnrs-mrs.fr ). 19 11 2001 © 2002 Biochemical Society 2002 computer analysis of metabolism metabolic modelling pathway analysis Trypanosoma brucei Metabolite Channelling and Metabolic Complexity 35 36 37 38 Cascante, M., Centelles, J. j. and Agius, L. (2000...