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Keywords: Toll-like receptorsClose
Biochem Soc Trans (2022) 50 (5): 1341–1352.
Published: 25 October 2022
... recently, studies have shown that ERK1/2 plays an essential role downstream of immune receptors to elicit inflammatory gene expression in response to infection and cell or tissue damage. Much of this work has studied ERK1/2 activation in Toll-like receptor (TLR) pathways, providing mechanistic insights...
In CollectionCelebrating 100 years of insulin research
Biochem Soc Trans (2020) 48 (3): 1213–1225.
Published: 08 June 2020
...Tae Kang Kim; Myung-Shik Lee The importance of innate immunity in host defense and inflammatory responses has been clearly demonstrated after the discovery of innate immune receptors such as Toll-like receptors (TLRs) or Nucleotide-binding oligomerization domain-containing protein (Nod)-like...
Biochem Soc Trans (2017) 45 (5): 1077–1085.
Published: 25 August 2017
... these pathways with a focus on Toll-like receptor and NOD-like receptor signalling. microscopy nod-like receptors Toll-like receptors The innate immune system provides the body's first line of defence against infection by inducing an inflammatory response. Many cell types, including both myeloid...
Biochem Soc Trans (2001) 29 (6): 853–859.
Published: 01 November 2001
... to members of an ancient family of defensive molecules, versions of which operate in virtually all multicellular life forms. In mammals, proteins of this family are now known as Toll-like receptors. They represent a point of direct contact, and first contact, between a pathogen and the host immune system...