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Keywords: Toll-like receptor
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Biochem Soc Trans (2008) 36 (6): 1478–1481.
Published: 19 November 2008
..., these CLRs induce signalling processes in DCs and specific cytokine responses in combination with TLR (Toll-like receptor) triggering. This implies that specific C-type lectin-targeted antigens can regulate T-cell polarization. Understanding the diversity of C-type lectins being expressed on DCs as well...
Biochem Soc Trans (2008) 36 (3): 453–458.
Published: 21 May 2008
.... The PRRs (pathogen recognition receptors) responsible for the innate detection of viruses have been discovered in recent years and include the TLRs (Toll-like receptors) and the cytosolic PRRs [RIG-I (retinoic acid-inducible gene I) and MDA-5 (melanoma-differentiation-associated gene 5)] [ 5 ]. The TLRs...
Biochem Soc Trans (2004) 32 (5): 789–791.
Published: 26 October 2004
... responses. Using mice deficient in the p110δ subunit of PI3K, we investigated the role of this subunit in LPS (lipopolysaccharide)-induced B cell responses, which are mediated by Toll-like receptor 4 and RP105. After injection of DNP-LPS (where DNP stands for 2,4-dinitrophenol), p110δ −/− mice produced...
Biochem Soc Trans (2000) 28 (5): 557–563.
Published: 01 October 2000
... subgroup is most similar to the Drosophila melanagaster protein Toll and includes Toll-like receptor 2 (TLR2), which is required for host defence against Gram-positive bacteria and fungi, and TLR4, which is required for lipopolysaccharide responsiveness, and thus is involved in host defence against Gram...