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Keywords: Tiam1
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Biochem Soc Trans (2005) 33 (6): 1303–1307.
Published: 26 October 2005
... domain) signalling protein Tiam1 Pleckstrin homology (PH) domains are protein modules of approx. 120 amino acids with approx. 250 representatives within the human genome [ 1 – 3 ]. Whilst many PH domains bind PIs (phosphoinositides), they often do so with relatively low affinity...
Biochem Soc Trans (2003) 31 (6): 1209–1212.
Published: 01 December 2003
... identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction pathways, particularly those initiated by the small GTPases Ras, Rho and Rac. Our recent work has shown that LPA signals Rac activation via the Tiam1 GDP/GTP exchange factor and thereby...