...Anthony J. Morgan; Lora L. Martucci; Lianne C. Davis; Antony Galione In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P 2 , TPCs are an integral part...

..., lysosome-related organelles (LROs)]. NAADP-induced Ca 2+ release absolutely requires organellar TPCs (two-pore channels). This review discusses how ER and acidic Ca 2+ stores physically and functionally interact to generate and shape global and local Ca 2+ signals, with particular emphasis on the two-way...

... of some recent robust challenges to the idea that two-pore channels (TPCs) represent the elusive “NAADP receptor”, evidence continues to accumulate that TPCs are important for NAADP-mediated responses. This article will briefly outline the background and review more recent work pertaining to the TPC story...