... by Portland Press Limited on behalf of the Biochemical Society 2021 endocytosis Epstein Barr virus exocytosis major histocompatibility complex T-cells viral particle release Autophagy describes at least three eukaryotic pathways for cytoplasmic constituent degradation in lysosomes [ 1–4...

...Benjamin S. Gully; Jamie Rossjohn; Martin S. Davey The γδ T cell immune cell lineage has remained relatively enigmatic and under-characterised since their identification. Conversely, the insights we have, highlight their central importance in diverse immunological roles and homeostasis. Thus, γδ T...

...Jessica P. Elmore; Michael C. McGee; Natalie F. Nidetz; Orchi Anannya; Weishan Huang; Avery August CD4 + effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase...

... to oppose activation of the pathway. knockout mice nuclear factor kappaB phosphorylation/dephosphorylation T-cells Protein phosphatase-6 (PP6) is a member of the PPP family of protein Ser/Thr phosphatases, enzymes with a bimetallic (Fe::Zn) catalytic center that distinguish them in terms...

...Lynsey M. Whilding; Sabari Vallath; John Maher Immunotherapy of cancer using chimeric antigen receptor (CAR) T-cells is a rapidly expanding field. CARs are fusion molecules that couple the binding of a tumour-associated cell surface target to the delivery of a tailored T-cell activating signal. Re...

... disordered membrane. Thus lipid rafts govern the lateral mobility and interaction of membrane proteins and regulate a plethora of signal transduction events, including T-cell antigen receptor (TCR) signalling. The pathways regulating homoeostasis of membrane cholesterol and GSLs are tightly controlled...