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Keywords: T-cells
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Biochem Soc Trans (2023) 51 (6): 2017–2028.
Published: 30 November 2023
... heterogeneity of tumor-infiltrating antigen-presenting cells (APCs). Reminiscent of the ‘second touch' hypothesis proposed by Klaus Ley for CD4+ T cell differentiation, the acquisition of full effector potential by lymph node- primed CD8+ T cells requires a second round of co-stimulation at the site where...
Biochem Soc Trans (2021) 49 (6): 2841–2851.
Published: 16 November 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 endocytosis Epstein Barr virus exocytosis major histocompatibility complex T-cells viral particle release Autophagy describes at least three eukaryotic pathways for cytoplasmic constituent degradation in lysosomes [ 1–4...
Biochem Soc Trans (2020) 48 (1): 179–185.
Published: 12 February 2020
...Jessica P. Elmore; Michael C. McGee; Natalie F. Nidetz; Orchi Anannya; Weishan Huang; Avery August CD4 + effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase...
Biochem Soc Trans (2017) 45 (3): 693–701.
Published: 15 June 2017
... to oppose activation of the pathway. knockout mice nuclear factor kappaB phosphorylation/dephosphorylation T-cells Protein phosphatase-6 (PP6) is a member of the PPP family of protein Ser/Thr phosphatases, enzymes with a bimetallic (Fe::Zn) catalytic center that distinguish them in terms...
Biochem Soc Trans (2016) 44 (2): 349–355.
Published: 11 April 2016
...Lynsey M. Whilding; Sabari Vallath; John Maher Immunotherapy of cancer using chimeric antigen receptor (CAR) T-cells is a rapidly expanding field. CARs are fusion molecules that couple the binding of a tumour-associated cell surface target to the delivery of a tailored T-cell activating signal. Re...
Biochem Soc Trans (2015) 43 (4): 745–751.
Published: 03 August 2015
... disordered membrane. Thus lipid rafts govern the lateral mobility and interaction of membrane proteins and regulate a plethora of signal transduction events, including T-cell antigen receptor (TCR) signalling. The pathways regulating homoeostasis of membrane cholesterol and GSLs are tightly controlled...