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Keywords: Saccharomyces cerevisiae
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Articles
Biochem Soc Trans (2021) 49 (2): 933–943.
Published: 26 March 2021
... by the shelterin complex (TRF1, TRF2, POT1, TPP1, TIN2 and Rap1) [ 2 ], while the Rap1–Rif1–Rif2 and Cdc13–Stn1–Ten1 (CST) complexes protect telomeres in the budding yeast Saccharomyces cerevisiae [ 1 , 6 ]. The vertebrate counterpart of the CST complex (CTC1–STN1–TEN1) interacts with shelterin and can also...
Articles
Biochem Soc Trans (2016) 44 (2): 517–527.
Published: 11 April 2016
... © 2016 Authors; published by Portland Press Limited 2016 biological transport ergosterol/analogues and derivatives/chemistry intracellular membranes/*metabolism membrane lipids/metabolism proteins/genetics/*metabolism proteins/genetics/metabolism saccharomyces cerevisiae vesicular...
Articles
Biochem Soc Trans (2014) 42 (4): 1256–1260.
Published: 11 August 2014
... compilation © 2014 Biochemical Society 2014 mRNA localization P-body Saccharomyces cerevisiae stress granule In eukaryotic cells, the information content of genes in the nucleus is transferred to the protein synthetic machinery in the cytoplasm via nucleocytoplasmic transport of the mRNA...
Articles
Biochem Soc Trans (2014) 42 (1): 160–165.
Published: 23 January 2014
... equally to this review. 2 To whom correspondence should be addressed (email i.stansfield@abdn.ac.uk ). 2 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 ribosomal pausing Saccharomyces cerevisiae translational regulation translation elongation tRNA...
Articles
Biochem Soc Trans (2014) 42 (1): 206–211.
Published: 23 January 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 Candida albicans Cdc42 filamentous growth G-protein phospholipid Saccharomyces cerevisiae A number of fungi can grow by asexual reproduction via budding growth, in which a small bud is formed on a mother cell...
Articles
Biochem Soc Trans (2013) 41 (2): 501–507.
Published: 21 March 2013
...Makkuni Jayaram; Keng-Ming Chang; Chien-Hui Ma; Chu-Chun Huang; Yen-Ting Liu; Soumitra Sau The partitioning locus STB of the selfish plasmid, the 2μm circle, of Saccharomyces cerevisiae is essential for the propagation of this multi-copy extra-chromosomal DNA element with nearly chromosome-like...
Articles
Biochem Soc Trans (2012) 40 (4): 794–799.
Published: 20 July 2012
...Clare E. Simpson; Mark P. Ashe For most eukaryotic organisms, including Saccharomyces cerevisiae , the rapid inhibition of protein synthesis forms part of a response to stress. In order to balance the changing conditions, precise stress-specific alterations to the cell's proteome are required...
Articles
Biochem Soc Trans (2012) 40 (4): 907–911.
Published: 20 July 2012
... of these ncRNAs (non-coding RNAs) are functional, and if so, what their function is. In this review, we describe recent discoveries in the field of ncRNAs in the yeast Saccharomyces cerevisiae . Newly identified ncRNAs in this budding yeast, their functions in gene regulation and possible mechanisms of action...
Articles
Biochem Soc Trans (2012) 40 (3): 555–560.
Published: 22 May 2012
...Tadhg P. Begley; Steven E. Ealick; Fred W. McLafferty The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae . The two pathways are quite different: in B. subtilis , the thiazole is formed by an oxidative condensation of glycine, deoxy...
Articles
Biochem Soc Trans (2011) 39 (5): 1499–1501.
Published: 21 September 2011
...Birthe Fahrenkrog The baker's yeast, Saccharomyces cerevisiae , is also capable of undergoing programmed cell death or apoptosis, for example in response to viral infection as well as during chronological and replicative aging. Intrinsically, programmed cell death in yeast can be induced...
Articles
Biochem Soc Trans (2011) 39 (5): 1185–1190.
Published: 21 September 2011
... and in mechanosensing. The powerful yeast genetics has contributed towards dissecting in detail the function and regulation of Saccharomyces cerevisiae myosins-I Myo3 and Myo5 in endocytic budding from the plasma membrane. In the present review, we summarize the evidence, dissecting their exact role in membrane budding...
Articles
Biochem Soc Trans (2011) 39 (5): 1502–1508.
Published: 21 September 2011
...@exeter.ac.uk ). 17 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis caspase necrosis programmed cell death (PCD) protease Saccharomyces cerevisiae Understanding the molecular mechanisms regulating and executing PCD (programmed cell death...
Articles
Biochem Soc Trans (2011) 39 (5): 1359–1364.
Published: 21 September 2011
...Li-Jun Chen; Elizabeth B. Sawyer; Sarah Perrett Ure2, a regulator of nitrogen metabolism, is the protein determinant of the [ URE3 ] prion state in Saccharomyces cerevisiae . Upon conversion into the prion form, Ure2 undergoes a heritable conformational change to an amyloid-like aggregated state...
Articles
Biochem Soc Trans (2011) 39 (5): 1520–1526.
Published: 21 September 2011
... of the mitochondrial compartment to the metabolic needs of the cell. The baker's yeast, Saccharomyces cerevisiae , is an established model for programmed cell death and aging research. The present review summarizes how mitochondrial morphology is altered on induction of cell death or on aging and how this correlates...
Articles
Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
...Nicoletta Guaragnella; Lucia Antonacci; Salvatore Passarella; Ersilia Marra; Sergio Giannattasio The use of non-mammalian model organisms, including yeast Saccharomyces cerevisiae , can provide new insights into eukaryotic PCD (programmed cell death) pathways. In the present paper, we report recent...
Articles
Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... the baker's yeast, Saccharomyces cerevisiae , as a highly tractable model. Such studies have, for example, identified novel mutant SOD1-specific interactions and demonstrated that mutant SOD1 disrupts mitochondrial homoeostasis. Features of ALS associated with TDP-43 aggregation have also been recapitulated...
Articles
Biochem Soc Trans (2010) 38 (5): 1257–1264.
Published: 24 September 2010
...Christian Waltermann; Edda Klipp A complex signalling network governs the response of Saccharomyces cerevisiae to an array of environmental stimuli and stresses. In the present article, we provide an overview of the main signalling system and discuss the mechanisms by which yeast integrates...
Articles
Biochem Soc Trans (2010) 38 (5): 1294–1301.
Published: 24 September 2010
... model of metabolism Saccharomyces cerevisiae Silicon Cell skeletal muscle Trypanosoma brucei Recently there has been a growing interest in applying systems biology approaches and, to a lesser extent, kinetic modelling to understand human metabolic diseases [ 1 – 3 ]. Clearly, progress...
Articles
Biochem Soc Trans (2010) 38 (5): 1225–1229.
Published: 24 September 2010
... Saccharomyces cerevisiae Systems biology studies the function and behaviour of biological systems and the interactions among the components of these systems; for example, metabolic networks and the interactions of the metabolites and enzymes that constitute them. Such systems exhibit highly non-linear...
Articles
Biochem Soc Trans (2009) 37 (5): 1115–1120.
Published: 21 September 2009
... and pyrimidine nucleotides. The Saccharomyces cerevisiae genome contains five genes, PRS1 – PRS5 , whose products display characteristic PRPP and bivalent-cation-binding sites of Prs polypeptides. Deletion of one or more of the five PRS genes has far-reaching and unexpected consequences, e.g. impaired cell...
Articles
Biochem Soc Trans (2009) 37 (1): 242–247.
Published: 20 January 2009
... 27 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 inner nuclear membrane latent transcription factor nutrient sensing receptor-activated proteolysis Saccharomyces cerevisiae SPS-sensing pathway A fundamental problem in biology is how cells...
Articles
Biochem Soc Trans (2008) 36 (3): 479–482.
Published: 21 May 2008
... in the budding yeast, Saccharomyces cerevisiae . Park et al. [ 13 ] described a plasmid-based BiFC system inspired by the Y2H strategy. They merged the principles of the Y2H and PCA technologies to design an EGFP reporter system with potential for high-throughput screening of interactions in yeast. Plasmid...
Articles
Biochem Soc Trans (2006) 34 (3): 359–362.
Published: 22 May 2006
... of these pathways moves exogenous sterols from the plasma membrane to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae . We have found that two classes of proteins play critical roles in this transport, ABC transporters (ATP-binding-cassette transporters) and oxysterol-binding protein-related...
Articles
Biochem Soc Trans (2005) 33 (6): 1447–1450.
Published: 26 October 2005
... and sometimes cell death. Genetic analyses in the yeast Saccharomyces cerevisiae have revealed a central role of the Srs2 helicase in preventing untimely HR events and in inhibiting the formation of potentially deleterious DNA structures or nucleoprotein complexes upon DNA replication stress. Paradoxically...
Articles
Biochem Soc Trans (2005) 33 (6): 1418–1420.
Published: 26 October 2005
...S. Vavassori; K. Wang; L.M. Schweizer; M. Schweizer The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho- D -ribosyl-1(α)-pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result...
Articles
Biochem Soc Trans (2005) 33 (5): 1170–1173.
Published: 26 October 2005
...K. Liu; X. Zhang; C. Sumanasekera; R.L. Lester; R.C. Dickson Over the past several years, studies of sphingolipid functions in the baker's yeast Saccharomyces cerevisiae have revealed that the sphingoid LCBs (long-chain bases), dihydrosphingosine and PHS (phytosphingosine), are important signalling...
Articles
Biochem Soc Trans (2005) 33 (5): 1186–1188.
Published: 26 October 2005
...S. Reiner; D. Micolod; R. Schneiter The molecular mechanisms that govern intracellular transport of sterols in eukaryotic cells are only poorly understood. Saccharomyces cerevisiae is a facultative anaerobic organism that requires supplementation with unsaturated fatty acids and sterols to grow...
Articles
Biochem Soc Trans (2005) 33 (5): 1154–1157.
Published: 26 October 2005
...S. Vavassori; K. Wang; L.M. Schweizer; M. Schweizer The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast...
Articles
Biochem Soc Trans (2005) 33 (1): 247–252.
Published: 01 February 2005
...M. Johnston; J.-H. Kim Because glucose is the principal carbon and energy source for most cells, most organisms have evolved numerous and sophisticated mechanisms for sensing glucose and responding to it appropriately. This is especially apparent in the yeast Saccharomyces cerevisiae , where...
Articles
Biochem Soc Trans (2005) 33 (1): 261–264.
Published: 01 February 2005
...P. Poulsen; B. Wu; R.F. Gaber; Kim Ottow; H.A. Andersen; M.C. Kielland-Brandt Saccharomyces cerevisiae senses extracellular amino acids using two members of the family of amino acid transporters, Gap1 or Ssy1; aspects of the latter are reviewed here. Despite resemblance with bona fide transporters...
Articles
Biochem Soc Trans (2001) 29 (2): 187–191.
Published: 01 May 2001
...C. W. Lawrence; V. M. Maher Translesion replication is a mechanism that employs specialized DNA polymerases for promoting continued nascent strand extension at forks blocked by the presence of unrepaired DNA damage. In Saccharomyces cerevisiae at least, this process contributes only modestly...
Articles
Biochem Soc Trans (2000) 28 (6): 654–658.
Published: 01 December 2000
...:4 Δ 5,8,11,14 ). An EST clone from P. patens was identified by its low homology to the yeast gene ELO1 , which is required for the elongation of medium-chain fatty acids. We functionally characterized this cDNA by heterologous expression in Saccharomyces cerevisiae grown in the presence of several...
Articles
Biochem Soc Trans (2000) 28 (6): 751–752.
Published: 01 December 2000
... Society 2000 Caenorhabditis elegans Candida albicans glycolipid Pichia pastoris Saccharomyces cerevisiae GlcT, ceramide glucosyltransferase GlcCer, glucosylceramide GSL, glycosphingolipid ORF. open reading frame Complex Lipid Biosynthesis: Sphingolipids Characterization...