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Keywords: SUMOylation
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Articles
Biochem Soc Trans (2019) 47 (6): 1881–1893.
Published: 26 November 2019
... targets for cancer treatment. DNA synthesis and repair double strand break DUB SENP sumoylation ubiquitin RAP80 is a reader of K63-Ub polymers at DSBs and serves as a docking module for the BRCA1-A complex [ 78–81 ]. In addition to K63-Ub, RAP80 interacts with SUMO chains, likely...
Articles
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
... of the Biochemical Society 2017 deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate...
Articles
Biochem Soc Trans (2010) 38 (1): 54–59.
Published: 19 January 2010
... and response. In the present review, we will focus on the influence of SUMO (small ubiquitin-related modifier) and ubiquitin modifications on the function of transcription factors involved in adrenal cortex formation, steroidogenesis and the hormonal response. Figure 1 SUMOylation and ubiquitylation...
Articles
Biochem Soc Trans (2009) 37 (5): 937–953.
Published: 21 September 2009
... Journal compilation © 2009 Biochemical Society 2009 deubiquitinase linear ubiquitin lysine linkage NEDDylation phosphorylation SUMOylation ubiquitination There is hardly any protein in the cell that does not encounter a post-translational modification within its lifespan. The amino...
Articles
Biochem Soc Trans (2008) 36 (5): 868–873.
Published: 19 September 2008
...Ana Talamillo; Jonatan Sánchez; Rosa Barrio SUMOylation, a reversible process used as a ‘fine-tuning’ mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular...
Articles
Biochem Soc Trans (2008) 36 (3): 445–448.
Published: 21 May 2008
... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. 1 To whom correspondence should be addressed (email cormac.taylor...
Articles
Biochem Soc Trans (2007) 35 (6): 1379–1384.
Published: 23 November 2007
...F.Z. Watts; A. Skilton; J.C.-Y. Ho; L.K. Boyd; M.A.M. Trickey; L. Gardner; F.-X. Ogi; E.A. Outwin SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear...
Articles
Biochem Soc Trans (2007) 35 (6): 1433–1435.
Published: 23 November 2007
...Y.-C. Wu; A.F. Deyrieux; V.G. Wilson SUMOylation of viral proteins is widespread and serves to modify or regulate the properties of those proteins. Papillomaviruses are a large group of small DNA viruses that infect the skin, leading to benign lesions (warts) that in some cases can progress...
Articles
Biochem Soc Trans (2007) 35 (6): 1401–1404.
Published: 23 November 2007
... © The Authors Journal compilation © 2007 Biochemical Society 2007 chromobox 4 (Cbx4) E3 ligase polycomb 2 protein (Pc2) polycomb repressive complex (PRC) small ubiquitin-related modifier (SUMO)-binding motif (SBM) SUMOylation Cbx chromobox CtBP C-terminal binding protein...
Articles
Biochem Soc Trans (2007) 35 (6): 1419–1421.
Published: 23 November 2007
... enzyme 9)], and substrate modification, through the co-operation of Ubc9 and E3 protein ligases. Work from our laboratory has shown the first example of a viral protein, Gam1, that binds to the E1 heterodimer, inhibiting its function and causing a complete block of the SUMOylation pathway both in vivo...
Articles
Biochem Soc Trans (2007) 35 (6): 1414–1418.
Published: 23 November 2007
...B. Guo; S.-H. Yang; J. Witty; A.D. Sharrocks The modification of proteins by SUMO (small ubiquitin-related modifier) conjugation is becoming increasingly recognized as an important regulatory event. Protein SUMOylation can control a whole range of activities, including subcellular localization...
Articles
Biochem Soc Trans (2007) 35 (6): 1422–1423.
Published: 23 November 2007
... conjugated to monomeric SUMO, all three SUMO family members are able to multimerize in vitro . In cells, SUMOs have the potential to multimerize via internal consensus sites for SUMOylation that are present in SUMO-2 and SUMO-3. A SUMO-binding motif in Ubc9 (ubiquitin-conjugating enzyme 9) contributes...
Articles
Biochem Soc Trans (2007) 35 (6): 1397–1400.
Published: 23 November 2007
... and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element-binding...