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Biochem Soc Trans (2020) 48 (5): 2159–2171.
Published: 23 September 2020
... proteins and complexes through ubiquitin-like modifiers. Nse2 codes for a C-terminal SP-RING domain with SUMO ligase activity, assisting Smc5/6 functions in chromosome segregation through sumoylation of several chromosome-associated proteins. Nse1 codes for a C-terminal NH-RING domain and, although it has...
In CollectionEmbryonic development
Ana Talamillo, Orhi Barroso-Gomila, Immacolata Giordano, Leiore Ajuria, Marco Grillo, Ugo Mayor, Rosa Barrio
Biochem Soc Trans (2020) 48 (2): 463–478.
Published: 20 April 2020
... is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a ‘molecular glue’ by promoting recruitment of chromatin regulators). SUMO modification results...
Biochem Soc Trans (2020) 48 (1): 123–135.
Published: 24 December 2019
...Nathalia Varejão; Jara Lascorz; Ying Li; David Reverter The small ubiquitin-like modifier (SUMO) is a post-translational modifier that can regulate the function of hundreds of proteins inside the cell. SUMO belongs to the ubiquitin-like family of proteins that can be attached to target proteins...
Biochem Soc Trans (2018) 46 (2): 423–436.
Published: 27 March 2018
...Huib Ovaa; Alfred C.O. Vertegaal Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins including small Ubl modifier (SUMO) are small proteins which are covalently linked to target proteins to regulate their functions. In this review, we discuss the current state of the art and point out what we feel...