... endothelial cell proliferation by dephosphorylating vascular endothelial growth factor receptor 2 (VEGFR2), but also supports VEGFR signaling by activating Src and AKT [ 58 ]. PTPRJ is phosphorylated at its C-terminal Tyr1311 and Tyr1320 by Src or Fyn, which allows the phosphatase to bind the Src SH2 domain...

...Z. Ahmed; T. S. Pillay APS [for ‘adapter protein with a pleckstrin homology (PH) and Src homology 2 (SH2) domain’] belongs to a family of adapter proteins involved in signalling by the receptors for insulin, insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor. Other...