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Keywords: SARS-CoV-2
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Coronavirus
Biochem Soc Trans (2024) 52 (1): 481–490.
Published: 22 February 2024
...Evangelos D. Karousis Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral infections. It plays a pivotal role in hijacking and rendering the host gene expression under the service of the virus. With a focus on SARS-CoV-2, this review presents how Nsp1...
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Coronavirus
Biochem Soc Trans (2023) 51 (6): 2127–2141.
Published: 18 December 2023
.... Multiple viruses are known to hijack the functions of aaRSs for proviral outcomes, while cells modify antiviral responses through non-canonical functions of certain synthetases. Recent findings have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent...
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Coronavirus
Biochem Soc Trans (2023) 51 (3): 1361–1375.
Published: 09 June 2023
...Xiyuan Bai; Tony Schountz; Ashley M. Buckle; Janet L. Talbert; Robert A. Sandhaus; Edward D. Chan Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID-19. Herein, we...
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Biochem Soc Trans (2023) 51 (2): 613–626.
Published: 17 March 2023
... inflammation neurological disorders SARS-CoV-2 The blood–brain barrier (BBB) formed by brain capillary endothelial cells is the dynamic physiological structure that protects the brain to maintain normal neuronal function. These highly specialised endothelial cells have intercellular tight junctions...
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Biochem Soc Trans (2021) 49 (1): 281–295.
Published: 13 January 2021
... recently, SARS-CoV-2 (COVID-19). Ivermectin has thus far been tested in Phase III human clinical trials for DENV, while there are currently close to 80 trials in progress worldwide for SARS-CoV-2; preliminary results for randomised clinical trials (RCTs) as well as observational/retrospective studies...
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Coronavirus
Biochem Soc Trans (2020) 48 (6): 2851–2863.
Published: 10 November 2020
...Jiayue-Clara Jiang; Yan Zhang The ongoing COVID-19 pandemic has placed an overwhelming burden on the healthcare system, and caused major disruption to the world economy. COVID-19 is caused by SARS-CoV-2, a novel coronavirus that leads to a variety of symptoms in humans, including cough, fever...
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Coronavirus
Biochem Soc Trans (2020) 48 (5): 2307–2316.
Published: 21 October 2020
...Zhongyi Wang; Yingying Fu; Zhendong Guo; Jiaming Li; Jingjing Li; Hongliang Cheng; Bing Lu; Qiang Sun The coronavirus disease 2019 (COVID-19), caused by a novel virus of the β-coronavirus genus (SARS-CoV-2), has been spreading globally. As of July 2020, there have been more than 17 million cases...
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Coronavirus
Biochem Soc Trans (2020) 48 (3): 1287–1295.
Published: 08 June 2020
...Spencer J. Williams; Ethan D. Goddard-Borger The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe. A return to normality is unlikely...