.... While traditionally it was thought that Rac1 activity drives protrusive lamellipodia at the leading edge of a polarised cell while RhoA drives rear retraction, more recent work in 3D microenvironments has revealed a much more complicated picture of GTPase dynamics. In particular, RhoA activity can...

... the mechanisms by which cAMP signalling maintains MLCP in an active state to control platelet contractile machinery. 1 To whom correspondence should be addressed (email a.aburima@hull.ac.uk ). 19 12 2013 Platelet stimulation through GPCRs linked to Gα 12/13 leads to the activation of RhoA...

... mglotzer@uchicago.edu ). 22 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 astral microtubule central spindle cytokinesis furrow formation RhoA Cytokinesis, the physical separation of nascent daughter cells, is one of life's most fundamental...