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Biochem Soc Trans (2018) 46 (3): 741–760.
Published: 05 June 2018
...Xosé R. Bustelo RHO GTPases have been traditionally associated with protumorigenic functions. While this paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO proteins can also play tumor suppressor roles. RHO signaling elements can also promote both pro...
Biochem Soc Trans (2014) 42 (2): 274–278.
Published: 20 March 2014
... endothelium Epac1 ezrin spreading Rho CVD (cardiovascular disease) is a leading cause of death in the developed world regardless of changes in lifestyle and increasing medical intervention [ 1 ]. Central to the maintenance of cardiovascular health is the vascular endothelium, which acts...
Biochem Soc Trans (2012) 40 (6): 1378–1382.
Published: 21 November 2012
...Alan Hall Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho...
Biochem Soc Trans (2008) 36 (3): 439–441.
Published: 21 May 2008
... they function together is poorly understood. Anillin can bind to numerous other furrow components, including F-actin, septins and myosin II, but its molecular functions are unclear. Recent data suggest that anillin participates in a previously unrecognized Rho-dependent pathway that can promote the association...
Biochem Soc Trans (2008) 36 (3): 378–380.
Published: 21 May 2008
... partially dependent on the small GTPase, Rho. Similar to other small GTPases, Rho cycles between the active (GTP-bound) and inactive (GDP-bound) states. Because of this switch-like behaviour, Rho and other members of the Rho GTPase family, such as Rac and Cdc42, have long been thought to work in a manner...
Biochem Soc Trans (2005) 33 (5): 891–895.
Published: 26 October 2005
...A. Hall Rho, Rac and Cdc42, three members of the Rho family of small GTPases, each control a signal transduction pathway linking membrane receptors to the assembly and disassembly of the actin cytoskeleton and of associated integrin adhesion complexes. Rho regulates stress fibre and focal adhesion...
Biochem Soc Trans (2005) 33 (4): 631–634.
Published: 01 August 2005
...K. Kurokawa; T. Nakamura; K. Aoki; M. Matsuda Rho-family GTPases regulate various aspects of cell function by controlling cytoskeletal changes; however, their spatial regulation within the cells remains largely unknown. To understand this regulation, we have studied the spatiotemporal activity...