...John M. O'shea; Neil D. Perkins The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting...

... modelling have identified that the timing of cellular responses may play an important role in the regulation of this pathway. p65/RelA (RelA) has been shown to translocate between the nucleus and cytoplasm with varying oscillatory patterns in different cell lines leading to differences in transcriptional...

... total NF-κB inhibition. Figure 1 UV-C, daunorubicin and TNF alter the mobility of RelA in one-dimensional SDS/PAGE U-2 OS cells were stimulated with 40 J/m 2 UV-C for 3 h, 1 μM daunorubicin for 3 h or 10 ng/ml TNF for 30 min as indicated. Nuclear protein extracts were prepared, analysed by one...

...N.D. Perkins The RelA(p65) NF-κB (nuclear factor κB) subunit is typically thought of as being antiapoptotic and tumour-promoting. However, in our laboratory, we have discovered that RelA can inhibit, rather than induce, antiapoptotic gene expression when activated by certain chemotherapeutic drugs...