... mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function. 1 To whom correspondence should be addressed (email cwalczak@indiana.edu ) . 9 9 2014 © The Authors Journal compilation ©...

...B. Goodman; Y. Zheng Assembly and disassembly of the mitotic spindle are essential for both chromosome segregation and cell division. The small G-protein Ran has emerged as an important regulator of spindle assembly. In this review, we look at the role of Ran in different aspects of spindle...

... in the cytoplasm (usually via the importin-α adaptor) and transports it through NPCs with which it interacts transiently by way of NPC proteins (‘nucleoporins’) that contain distinctive FG (Phe-Gly) sequence repeats. In the nucleus, Ran-GTP binds to importin-β, dissociating the import complex. The importin-β–Ran...