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Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 951–955.
Published: 18 July 2013
... and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases localize mTORC1 to lysosomes by their amino-acid-dependent interaction with the lysosomal Ragulator complex. Rheb is also thought to reside on lysosomes to activate mTORC1...